Spectroscopy of nanoparticles based on Gd{sub 14}B{sub 6}Ge{sub 2}O{sub 34} polycrystals and La{sub 2}O{sub 3} - B{sub 2}O{sub 3} glasses, activated by Nd{sup 3+} ions, for cancer diagnostics

Journal Article · Mon Jan 24 00:00:00 EST 2011 · Quantum Electronics (Woodbury, N.Y.)

DOI:https://doi.org/10.1070/QE2010V040N12ABEH014472· OSTI ID:21541813

Popov, A V; Ryabova, A V; Loshchenov, V B; Voronko, Yu K ^[1]; Komova, M G; Krut'ko, V A ^[2]; Petrova, O B ^[3]

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1. A M Prokhorov General Physics Institute, Russian Academy of Sciences, Moscow (Russian Federation)
2. N.S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow (Russian Federation)
3. D.I. Mendeleev Russian University of Chemical Technology, Moscow (Russian Federation)

Nanoparticles of gadolinium borate polycrystals and borate glasses, activated by Nd3+ ions, are obtained from macroscopic samples of the corresponding compositions by mechanical grinding and ultrasonic dispersion in water. A spectroscopic study of these nanoparticles in the near-IR region is performed to determine their potential as luminescence biosensors and radiopharmaceutical preparations for cancer diagnostics by radiosensitive methods. A twofold increase in the lifetime of the metastable {sup 4}F{sub 3/2} state of Nd{sup 3+} ions at the transition from submicron polycrystalline particles to nanoparticles is experimentally found. A study of the nanoparticle distribution over organs and tissues of laboratory animals, performed with a 810-nm laser for exciting luminescence and a multichannel fibre spectrometer for measuring fluorescence in the range of 0.8 - 1.2 mm, showed this technique to be sufficiently sensitive to reliably determine the nanoparticle concentration in biological tissues and the dynamics of its change. (application of lasers and laser-optical methods in life sciences)

• OSTI ID: 21541813
• Journal Information: Quantum Electronics (Woodbury, N.Y.), Vol. 40, Issue 12; Other Information: DOI: 10.1070/QE2010v040n12ABEH014472; ISSN 1063-7818
• Country of Publication: United States
• Language: English

Related Subjects

36 MATERIALS SCIENCE
BORATES
BORON OXIDES
FLUORESCENCE
GADOLINIUM OXIDES
GLASS
LABORATORY ANIMALS
LANTHANUM OXIDES
LASERS
NANOSTRUCTURES
NEODYMIUM IONS
NEOPLASMS
PARTICLES
POLYCRYSTALS
RADIOPHARMACEUTICALS
SPECTROSCOPY
ANIMALS
BORON COMPOUNDS
CHALCOGENIDES
CHARGED PARTICLES
CRYSTALS
DISEASES
DRUGS
EMISSION
GADOLINIUM COMPOUNDS
IONS
LABELLED COMPOUNDS
LANTHANUM COMPOUNDS
LUMINESCENCE
MATERIALS
OXIDES
OXYGEN COMPOUNDS
PHOTON EMISSION
RADIOACTIVE MATERIALS
RARE EARTH COMPOUNDS