skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Magnetite Nanoparticles Coated with Rifampicin and Chlortetracycline for Drug Delivery Applications

Abstract

Four types of biocompatible magnetic fluids based on superparamagnetic nanoparticles with Fe{sub 3}O{sub 4} cores were functionalized with antibiotics (rifampicin or chlortetracycline) as potential candidates for in vivo biomedical applications, such as magnetically controlled drug delivery. The synthesis consisted in coprecipitation of iron oxide in basic, as well as in acid medium, followed by the dispersion of the resulted magnetite nanoparticles in aqueous solution containing the antibiotic. The chosen method to prepare the magnetite-core/drug-shell systems avoided intermediate organic coating of the magnetic nanoparticles. Comparative analysis of the rheological features of the aqueous magnetic fluid samples was performed. The structural features of the coated magnetic particles were investigated by X-Ray Diffraction (XRD), Transmission Electron Microscopy (TEM) and Vibrating Sample Magnetometry (VSM). Good crystallinity and adequate stability in time were evidenced. Drug delivery curves were spectrophotometrically provided.

Authors:
; ; ;  [1];  [2]
  1. Faculty of Physics, Alexandru Ioan Cuza University of Iasi, 11A Carol I Bd., 700506, Iasi (Romania)
  2. National Institute of Research and Development for Technical Physics, 7 Mangeron Bd., Iasi (Romania)
Publication Date:
OSTI Identifier:
21506935
Resource Type:
Journal Article
Journal Name:
AIP Conference Proceedings
Additional Journal Information:
Journal Volume: 1311; Journal Issue: 1; Conference: 8. international conference on the scientific and clinical applications of magnetic carriers, Rostock (Germany), 25-29 May 2010; Other Information: DOI: 10.1063/1.3530043; (c) 2010 American Institute of Physics; Journal ID: ISSN 0094-243X
Country of Publication:
United States
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY; AQUEOUS SOLUTIONS; COPRECIPITATION; DELIVERY; FERRITES; FLUIDS; IN VIVO; IRON OXIDES; MAGNETITE; NANOSTRUCTURES; SCANNING ELECTRON MICROSCOPY; STABILITY; SUPERPARAMAGNETISM; SYNTHESIS; TETRACYCLINES; TRANSMISSION ELECTRON MICROSCOPY; VIBRATING SAMPLE MAGNETOMETERS; X-RAY DIFFRACTION; ANTIBIOTICS; ANTI-INFECTIVE AGENTS; CHALCOGENIDES; COHERENT SCATTERING; DIFFRACTION; DISPERSIONS; DRUGS; ELECTRON MICROSCOPY; FERRIMAGNETIC MATERIALS; HOMOGENEOUS MIXTURES; IRON COMPOUNDS; IRON ORES; MAGNETIC MATERIALS; MAGNETISM; MAGNETOMETERS; MATERIALS; MEASURING INSTRUMENTS; MICROSCOPY; MINERALS; MIXTURES; ORES; ORGANIC COMPOUNDS; OXIDE MINERALS; OXIDES; OXYGEN COMPOUNDS; PRECIPITATION; SCATTERING; SEPARATION PROCESSES; SOLUTIONS; TRANSITION ELEMENT COMPOUNDS

Citation Formats

Nadejde, Claudia, Ciurlica, Ecaterina Foca-nici, Creanga, Dorina, Carlescu, Aurelian, and Badescu, Vasile. Magnetite Nanoparticles Coated with Rifampicin and Chlortetracycline for Drug Delivery Applications. United States: N. p., 2010. Web. doi:10.1063/1.3530043.
Nadejde, Claudia, Ciurlica, Ecaterina Foca-nici, Creanga, Dorina, Carlescu, Aurelian, & Badescu, Vasile. Magnetite Nanoparticles Coated with Rifampicin and Chlortetracycline for Drug Delivery Applications. United States. https://doi.org/10.1063/1.3530043
Nadejde, Claudia, Ciurlica, Ecaterina Foca-nici, Creanga, Dorina, Carlescu, Aurelian, and Badescu, Vasile. 2010. "Magnetite Nanoparticles Coated with Rifampicin and Chlortetracycline for Drug Delivery Applications". United States. https://doi.org/10.1063/1.3530043.
@article{osti_21506935,
title = {Magnetite Nanoparticles Coated with Rifampicin and Chlortetracycline for Drug Delivery Applications},
author = {Nadejde, Claudia and Ciurlica, Ecaterina Foca-nici and Creanga, Dorina and Carlescu, Aurelian and Badescu, Vasile},
abstractNote = {Four types of biocompatible magnetic fluids based on superparamagnetic nanoparticles with Fe{sub 3}O{sub 4} cores were functionalized with antibiotics (rifampicin or chlortetracycline) as potential candidates for in vivo biomedical applications, such as magnetically controlled drug delivery. The synthesis consisted in coprecipitation of iron oxide in basic, as well as in acid medium, followed by the dispersion of the resulted magnetite nanoparticles in aqueous solution containing the antibiotic. The chosen method to prepare the magnetite-core/drug-shell systems avoided intermediate organic coating of the magnetic nanoparticles. Comparative analysis of the rheological features of the aqueous magnetic fluid samples was performed. The structural features of the coated magnetic particles were investigated by X-Ray Diffraction (XRD), Transmission Electron Microscopy (TEM) and Vibrating Sample Magnetometry (VSM). Good crystallinity and adequate stability in time were evidenced. Drug delivery curves were spectrophotometrically provided.},
doi = {10.1063/1.3530043},
url = {https://www.osti.gov/biblio/21506935}, journal = {AIP Conference Proceedings},
issn = {0094-243X},
number = 1,
volume = 1311,
place = {United States},
year = {Thu Dec 02 00:00:00 EST 2010},
month = {Thu Dec 02 00:00:00 EST 2010}
}