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Title: Relationship Between Diseased Lung Tissues on Computed Tomography and Motion of Fiducial Marker Near Lung Cancer

Abstract

Purpose: For lung cancer patients with poor pulmonary function because of emphysema or fibrosis, it is important to predict the amplitude of internal tumor motion to minimize the irradiation of the functioning lung tissue before undergoing stereotactic body radiotherapy. Methods and Materials: Two board-certified diagnostic radiologists independently assessed the degree of pulmonary emphysema and fibrosis on computed tomography scans in 71 patients with peripheral lung tumors before real-time tumor-tracking radiotherapy. The relationships between the computed tomography findings of the lung parenchyma and the motion of the fiducial marker near the lung tumor were investigated. Of the 71 patients, 30 had normal pulmonary function, and 29 had obstructive pulmonary dysfunction (forced expiratory volume in 1 s/forced vital capacity ratio of <70%), 6 patients had constrictive dysfunction (percentage of vital capacity <80%), and 16 had mixed dysfunction. Results: The upper region was associated with smaller tumor motion, as expected (p = .0004), and the presence of fibrosis (p = .088) and pleural tumor contact (p = .086) were weakly associated with tumor motion. The presence of fibrotic changes in the lung tissue was associated with smaller tumor motion in the upper region (p <.05) but not in the lower region. The findingsmore » of emphysema and pulmonary function tests were not associated with tumor motion. Conclusion: Tumors in the upper lung region with fibrotic changes have smaller motion than those in the upper region of the lungs without fibrotic changes. The tumor motion in the lower lung region was not significantly different between patients with and without lung fibrosis. Emphysema was not associated with the amplitude of tumor motion.« less

Authors:
 [1]; ; ;  [1];  [2]; ; ; ;  [1]; ;  [3];  [1]
  1. Department of Radiology, Hokkaido University Hospital, Sapporo (Japan)
  2. Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA (United States)
  3. Department of First Internal Medicine, Hokkaido University Graduate School of Medicine, Sapporo (Japan)
Publication Date:
OSTI Identifier:
21491683
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 79; Journal Issue: 5; Other Information: DOI: 10.1016/j.ijrobp.2010.01.008; PII: S0360-3016(10)00031-3; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; COMPUTERIZED TOMOGRAPHY; EMPHYSEMA; FIBROSIS; LUNGS; MOTION; NEOPLASMS; RADIOTHERAPY; BODY; DIAGNOSTIC TECHNIQUES; DISEASES; MEDICINE; NUCLEAR MEDICINE; ORGANS; PATHOLOGICAL CHANGES; RADIOLOGY; RESPIRATORY SYSTEM; RESPIRATORY SYSTEM DISEASES; THERAPY; TOMOGRAPHY

Citation Formats

Onodera, Yuya, Nishioka, Noriko, Yasuda, Koichi, Fujima, Noriyuki, Torres, Mylin, Kamishima, Tamotsu, Ooyama, Noriko, Onimaru, Rikiya, Terae, Satoshi, Ooizumi, Satoshi, Nishimura, Masaharu, and Shirato, Hiroki. Relationship Between Diseased Lung Tissues on Computed Tomography and Motion of Fiducial Marker Near Lung Cancer. United States: N. p., 2011. Web. doi:10.1016/j.ijrobp.2010.01.008.
Onodera, Yuya, Nishioka, Noriko, Yasuda, Koichi, Fujima, Noriyuki, Torres, Mylin, Kamishima, Tamotsu, Ooyama, Noriko, Onimaru, Rikiya, Terae, Satoshi, Ooizumi, Satoshi, Nishimura, Masaharu, & Shirato, Hiroki. Relationship Between Diseased Lung Tissues on Computed Tomography and Motion of Fiducial Marker Near Lung Cancer. United States. https://doi.org/10.1016/j.ijrobp.2010.01.008
Onodera, Yuya, Nishioka, Noriko, Yasuda, Koichi, Fujima, Noriyuki, Torres, Mylin, Kamishima, Tamotsu, Ooyama, Noriko, Onimaru, Rikiya, Terae, Satoshi, Ooizumi, Satoshi, Nishimura, Masaharu, and Shirato, Hiroki. 2011. "Relationship Between Diseased Lung Tissues on Computed Tomography and Motion of Fiducial Marker Near Lung Cancer". United States. https://doi.org/10.1016/j.ijrobp.2010.01.008.
@article{osti_21491683,
title = {Relationship Between Diseased Lung Tissues on Computed Tomography and Motion of Fiducial Marker Near Lung Cancer},
author = {Onodera, Yuya and Nishioka, Noriko and Yasuda, Koichi and Fujima, Noriyuki and Torres, Mylin and Kamishima, Tamotsu and Ooyama, Noriko and Onimaru, Rikiya and Terae, Satoshi and Ooizumi, Satoshi and Nishimura, Masaharu and Shirato, Hiroki},
abstractNote = {Purpose: For lung cancer patients with poor pulmonary function because of emphysema or fibrosis, it is important to predict the amplitude of internal tumor motion to minimize the irradiation of the functioning lung tissue before undergoing stereotactic body radiotherapy. Methods and Materials: Two board-certified diagnostic radiologists independently assessed the degree of pulmonary emphysema and fibrosis on computed tomography scans in 71 patients with peripheral lung tumors before real-time tumor-tracking radiotherapy. The relationships between the computed tomography findings of the lung parenchyma and the motion of the fiducial marker near the lung tumor were investigated. Of the 71 patients, 30 had normal pulmonary function, and 29 had obstructive pulmonary dysfunction (forced expiratory volume in 1 s/forced vital capacity ratio of <70%), 6 patients had constrictive dysfunction (percentage of vital capacity <80%), and 16 had mixed dysfunction. Results: The upper region was associated with smaller tumor motion, as expected (p = .0004), and the presence of fibrosis (p = .088) and pleural tumor contact (p = .086) were weakly associated with tumor motion. The presence of fibrotic changes in the lung tissue was associated with smaller tumor motion in the upper region (p <.05) but not in the lower region. The findings of emphysema and pulmonary function tests were not associated with tumor motion. Conclusion: Tumors in the upper lung region with fibrotic changes have smaller motion than those in the upper region of the lungs without fibrotic changes. The tumor motion in the lower lung region was not significantly different between patients with and without lung fibrosis. Emphysema was not associated with the amplitude of tumor motion.},
doi = {10.1016/j.ijrobp.2010.01.008},
url = {https://www.osti.gov/biblio/21491683}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 5,
volume = 79,
place = {United States},
year = {Fri Apr 01 00:00:00 EDT 2011},
month = {Fri Apr 01 00:00:00 EDT 2011}
}