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Title: Pelvic Lymph Node Status Assessed by 18F-Fluorodeoxyglucose Positron Emission Tomography Predicts Low-Risk Group for Distant Recurrence in Locally Advanced Cervical Cancer: A Prospective Study

Abstract

Purpose: To develop a prediction model to identify a low-risk group for distant recurrence in patients with locally advanced cervical cancer treated by concurrent chemoradiation. Methods and Materials: Prospectively, 62 patients with locally advanced cervical cancer were recruited as a training cohort. Clinical variables and parameters obtained from positron emission tomography (PET) and magnetic resonance imaging were analyzed by logistic regression. For the test set, 54 patients were recruited independently. To identify the low-risk group, negative likelihood ratio (LR) less than 0.2 was set to be a cutoff. Results: Among the training cohort, multivariate logistic analysis revealed that advanced International Federation of Gynecology and Obstetrics (FIGO) stage and a high serum squamous cancer cell (SCC) antigen level were significant risk factors (p = 0.015 and 0.025, respectively). Using the two parameters, criteria to determine a low-risk subset for distant recurrence were postulated: (1) FIGO Stage IIB or less and (2) pretreatment SCC < 2.4 (Model A). Positive pelvic node on PET completely predicted all cases with distant recurrence and thus was considered as another prediction model (Model B). In the test cohort, although Model A did not showed diagnostic performance, Model B completely predicted all cases with distant recurrence andmore » showed a sensitivity of 100% with negative LR of 0. Across the training and test cohort (n = 116), the false negative rate was 0 (95% confidence interval 0%-7.6%). Conclusions: Positive pelvic node on PET is a useful marker in prediction of distant recurrence in patients with locally advanced cervical cancer who are treated with concurrent chemoradiation.« less

Authors:
 [1]; ; ; ;  [1];  [2]; ; ; ;  [1]
  1. Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang (Korea, Republic of)
  2. Center for Diagnostic Oncology, Research Institute and Hospital, National Cancer Center, Goyang (Korea, Republic of)
Publication Date:
OSTI Identifier:
21491616
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 79; Journal Issue: 3; Other Information: DOI: 10.1016/j.ijrobp.2009.11.031; PII: S0360-3016(09)03572-X; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ANTIGENS; COMBINED THERAPY; FLUORINE 18; FLUORODEOXYGLUCOSE; LYMPH NODES; MULTIVARIATE ANALYSIS; NEOPLASMS; NMR IMAGING; POSITRON COMPUTED TOMOGRAPHY; UROGENITAL SYSTEM DISEASES; ANTIMETABOLITES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; LYMPHATIC SYSTEM; MATHEMATICS; MEDICINE; NANOSECONDS LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; RADIOISOTOPES; STATISTICS; THERAPY; TOMOGRAPHY

Citation Formats

Kang, Sokbom, E-mail: sokbom@ncc.re.k, Park, Jung-Yeol, Lim, Myung-Chul, Song, Yong-Joong, Park, Se-Hyun, Kim, Seok-Ki, Chung, Dae-Chul, Seo, Sang-Soo, Kim, Joo-Young, and Park, Sang-Yoon. Pelvic Lymph Node Status Assessed by 18F-Fluorodeoxyglucose Positron Emission Tomography Predicts Low-Risk Group for Distant Recurrence in Locally Advanced Cervical Cancer: A Prospective Study. United States: N. p., 2011. Web. doi:10.1016/j.ijrobp.2009.11.031.
Kang, Sokbom, E-mail: sokbom@ncc.re.k, Park, Jung-Yeol, Lim, Myung-Chul, Song, Yong-Joong, Park, Se-Hyun, Kim, Seok-Ki, Chung, Dae-Chul, Seo, Sang-Soo, Kim, Joo-Young, & Park, Sang-Yoon. Pelvic Lymph Node Status Assessed by 18F-Fluorodeoxyglucose Positron Emission Tomography Predicts Low-Risk Group for Distant Recurrence in Locally Advanced Cervical Cancer: A Prospective Study. United States. doi:10.1016/j.ijrobp.2009.11.031.
Kang, Sokbom, E-mail: sokbom@ncc.re.k, Park, Jung-Yeol, Lim, Myung-Chul, Song, Yong-Joong, Park, Se-Hyun, Kim, Seok-Ki, Chung, Dae-Chul, Seo, Sang-Soo, Kim, Joo-Young, and Park, Sang-Yoon. Tue . "Pelvic Lymph Node Status Assessed by 18F-Fluorodeoxyglucose Positron Emission Tomography Predicts Low-Risk Group for Distant Recurrence in Locally Advanced Cervical Cancer: A Prospective Study". United States. doi:10.1016/j.ijrobp.2009.11.031.
@article{osti_21491616,
title = {Pelvic Lymph Node Status Assessed by 18F-Fluorodeoxyglucose Positron Emission Tomography Predicts Low-Risk Group for Distant Recurrence in Locally Advanced Cervical Cancer: A Prospective Study},
author = {Kang, Sokbom, E-mail: sokbom@ncc.re.k and Park, Jung-Yeol and Lim, Myung-Chul and Song, Yong-Joong and Park, Se-Hyun and Kim, Seok-Ki and Chung, Dae-Chul and Seo, Sang-Soo and Kim, Joo-Young and Park, Sang-Yoon},
abstractNote = {Purpose: To develop a prediction model to identify a low-risk group for distant recurrence in patients with locally advanced cervical cancer treated by concurrent chemoradiation. Methods and Materials: Prospectively, 62 patients with locally advanced cervical cancer were recruited as a training cohort. Clinical variables and parameters obtained from positron emission tomography (PET) and magnetic resonance imaging were analyzed by logistic regression. For the test set, 54 patients were recruited independently. To identify the low-risk group, negative likelihood ratio (LR) less than 0.2 was set to be a cutoff. Results: Among the training cohort, multivariate logistic analysis revealed that advanced International Federation of Gynecology and Obstetrics (FIGO) stage and a high serum squamous cancer cell (SCC) antigen level were significant risk factors (p = 0.015 and 0.025, respectively). Using the two parameters, criteria to determine a low-risk subset for distant recurrence were postulated: (1) FIGO Stage IIB or less and (2) pretreatment SCC < 2.4 (Model A). Positive pelvic node on PET completely predicted all cases with distant recurrence and thus was considered as another prediction model (Model B). In the test cohort, although Model A did not showed diagnostic performance, Model B completely predicted all cases with distant recurrence and showed a sensitivity of 100% with negative LR of 0. Across the training and test cohort (n = 116), the false negative rate was 0 (95% confidence interval 0%-7.6%). Conclusions: Positive pelvic node on PET is a useful marker in prediction of distant recurrence in patients with locally advanced cervical cancer who are treated with concurrent chemoradiation.},
doi = {10.1016/j.ijrobp.2009.11.031},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 3,
volume = 79,
place = {United States},
year = {Tue Mar 01 00:00:00 EST 2011},
month = {Tue Mar 01 00:00:00 EST 2011}
}