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Title: Application of time gating in the measurement of glucose level in a three-layer biotissue model by using ultrashort laser pulses

Abstract

The efficiency of using the time-of-flight (TOF) method at a wavelength of 820 nm for detecting the changes in the optical properties of multilayer light scattering medium in connection with the problem of the glucose level detection in the human tissue is discussed. Pulses scattered from a three-layer biotissue phantom consisting of two skin layers and a blood layer between them, are calculated with the help of a program code based on the Monte Carlo algorithm for different glucose concentrations. Relative changes in the recorded signals caused by variations in the glucose content are analysed for different source - detector separations. It is shown that the maximum relative change in the total pulse energy is 7.2% and 4.8% for the anisotropy factor of the layer mimicking skin g = 0.9 and 0.7, respectively, and the change in the glucose concentration from 0 up to 500 mg dL{sup -1}. The use of time gating leads to the increase in these values up to 12% and 8.5%, respectively. The sensitivity maps are obtained which can be used to determine the optimal duration and the time delay of the time gate relative to the probe pulse for five values of the source -more » detector separations. (biophotonics)« less

Authors:
; ;  [1];  [2]
  1. M. V. Lomonosov Moscow State University, Faculty of Physics, Moscow (Russian Federation)
  2. University of Oulu, Optoelectronics and Measurements Techniques Laboratory (Finland)
Publication Date:
OSTI Identifier:
21466815
Resource Type:
Journal Article
Journal Name:
Quantum Electronics (Woodbury, N.Y.)
Additional Journal Information:
Journal Volume: 38; Journal Issue: 5; Other Information: DOI: 10.1070/QE2008v038n05ABEH013792; Journal ID: ISSN 1063-7818
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; ALGORITHMS; ANIMAL TISSUES; ANISOTROPY; BLOOD; EFFICIENCY; GLUCOSE; LAYERS; LIGHT SCATTERING; MONTE CARLO METHOD; OPTICAL PROPERTIES; PHANTOMS; PULSES; SENSITIVITY; SIGNALS; SKIN; TIME DELAY; TIME-OF-FLIGHT METHOD; WAVELENGTHS; ALDEHYDES; BIOLOGICAL MATERIALS; BODY; BODY FLUIDS; CALCULATION METHODS; CARBOHYDRATES; HEXOSES; MATERIALS; MATHEMATICAL LOGIC; MOCKUP; MONOSACCHARIDES; ORGANIC COMPOUNDS; ORGANS; PHYSICAL PROPERTIES; SACCHARIDES; SCATTERING; STRUCTURAL MODELS

Citation Formats

Kirillin, M Yu, Bykov, A V, Priezzhev, A V, and Myllylae, R. Application of time gating in the measurement of glucose level in a three-layer biotissue model by using ultrashort laser pulses. United States: N. p., 2008. Web. doi:10.1070/QE2008V038N05ABEH013792.
Kirillin, M Yu, Bykov, A V, Priezzhev, A V, & Myllylae, R. Application of time gating in the measurement of glucose level in a three-layer biotissue model by using ultrashort laser pulses. United States. https://doi.org/10.1070/QE2008V038N05ABEH013792
Kirillin, M Yu, Bykov, A V, Priezzhev, A V, and Myllylae, R. 2008. "Application of time gating in the measurement of glucose level in a three-layer biotissue model by using ultrashort laser pulses". United States. https://doi.org/10.1070/QE2008V038N05ABEH013792.
@article{osti_21466815,
title = {Application of time gating in the measurement of glucose level in a three-layer biotissue model by using ultrashort laser pulses},
author = {Kirillin, M Yu and Bykov, A V and Priezzhev, A V and Myllylae, R},
abstractNote = {The efficiency of using the time-of-flight (TOF) method at a wavelength of 820 nm for detecting the changes in the optical properties of multilayer light scattering medium in connection with the problem of the glucose level detection in the human tissue is discussed. Pulses scattered from a three-layer biotissue phantom consisting of two skin layers and a blood layer between them, are calculated with the help of a program code based on the Monte Carlo algorithm for different glucose concentrations. Relative changes in the recorded signals caused by variations in the glucose content are analysed for different source - detector separations. It is shown that the maximum relative change in the total pulse energy is 7.2% and 4.8% for the anisotropy factor of the layer mimicking skin g = 0.9 and 0.7, respectively, and the change in the glucose concentration from 0 up to 500 mg dL{sup -1}. The use of time gating leads to the increase in these values up to 12% and 8.5%, respectively. The sensitivity maps are obtained which can be used to determine the optimal duration and the time delay of the time gate relative to the probe pulse for five values of the source - detector separations. (biophotonics)},
doi = {10.1070/QE2008V038N05ABEH013792},
url = {https://www.osti.gov/biblio/21466815}, journal = {Quantum Electronics (Woodbury, N.Y.)},
issn = {1063-7818},
number = 5,
volume = 38,
place = {United States},
year = {Sat May 31 00:00:00 EDT 2008},
month = {Sat May 31 00:00:00 EDT 2008}
}