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Title: Simulations of a spatially resolved reflectometry signal from a highly scattering three-layer medium applied to the problem of glucose sensing in human skin

Abstract

The possibility of using spatially resolved reflectometry (SRR) at a wavelength of 820 nm to detect changes in the optical properties of a highly scattering layered random medium simulating a biological tissue caused by changes in the glucose level is analysed. Model signals from a three-layer biological tissue phantom consisting of two skin layers and a blood layer located between them are obtained by the Monte-Carlo method. It was assumed that variations in the glucose level induce variations in the optical parameters of the blood layer and the bottom skin layer. To analyse the trajectories of photons forming the SRR signal, their scattering maps are obtained. The ratio of the photon path in layers sensitive to the glucose level to the total path in the medium was used as a parameter characterising these trajectories. The relative change in the reflected signal caused by a change in the glucose concentration is analysed depending on the distance between a probe radiation source and a detector. It is shown that the maximum relative change in the signal (about 7%) takes place for the source - detector separation in the range from 0.3 to 0.5 mm depending on the model parameters. (special issue devotedmore » to multiple radiation scattering in random media)« less

Authors:
; ;  [1];  [2]
  1. Department of Physics, M.V. Lomonosov Moscow State University, Moscow (Russian Federation)
  2. Department of Electrical and Information Engineering, Optoelectronics and Measurement Techniques Laboratory, University of Oulu (Finland)
Publication Date:
OSTI Identifier:
21459999
Resource Type:
Journal Article
Resource Relation:
Journal Name: Quantum Electronics (Woodbury, N.Y.); Journal Volume: 36; Journal Issue: 12; Other Information: DOI: 10.1070/QE2006v036n12ABEH013457
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; BLOOD; GLUCOSE; LAYERS; MONTE CARLO METHOD; OPTICAL PROPERTIES; PHANTOMS; PHOTONS; RADIATION SOURCES; REFLECTION; SCATTERING; SIGNALS; SKIN; SPATIAL RESOLUTION; TRAJECTORIES; WAVELENGTHS; ALDEHYDES; BIOLOGICAL MATERIALS; BODY; BODY FLUIDS; BOSONS; CALCULATION METHODS; CARBOHYDRATES; ELEMENTARY PARTICLES; HEXOSES; MASSLESS PARTICLES; MATERIALS; MOCKUP; MONOSACCHARIDES; ORGANIC COMPOUNDS; ORGANS; PHYSICAL PROPERTIES; RESOLUTION; SACCHARIDES; STRUCTURAL MODELS

Citation Formats

Bykov, A V, Kirillin, M Yu, Priezzhev, A V, and Myllylae, Risto. Simulations of a spatially resolved reflectometry signal from a highly scattering three-layer medium applied to the problem of glucose sensing in human skin. United States: N. p., 2006. Web. doi:10.1070/QE2006V036N12ABEH013457.
Bykov, A V, Kirillin, M Yu, Priezzhev, A V, & Myllylae, Risto. Simulations of a spatially resolved reflectometry signal from a highly scattering three-layer medium applied to the problem of glucose sensing in human skin. United States. doi:10.1070/QE2006V036N12ABEH013457.
Bykov, A V, Kirillin, M Yu, Priezzhev, A V, and Myllylae, Risto. Sun . "Simulations of a spatially resolved reflectometry signal from a highly scattering three-layer medium applied to the problem of glucose sensing in human skin". United States. doi:10.1070/QE2006V036N12ABEH013457.
@article{osti_21459999,
title = {Simulations of a spatially resolved reflectometry signal from a highly scattering three-layer medium applied to the problem of glucose sensing in human skin},
author = {Bykov, A V and Kirillin, M Yu and Priezzhev, A V and Myllylae, Risto},
abstractNote = {The possibility of using spatially resolved reflectometry (SRR) at a wavelength of 820 nm to detect changes in the optical properties of a highly scattering layered random medium simulating a biological tissue caused by changes in the glucose level is analysed. Model signals from a three-layer biological tissue phantom consisting of two skin layers and a blood layer located between them are obtained by the Monte-Carlo method. It was assumed that variations in the glucose level induce variations in the optical parameters of the blood layer and the bottom skin layer. To analyse the trajectories of photons forming the SRR signal, their scattering maps are obtained. The ratio of the photon path in layers sensitive to the glucose level to the total path in the medium was used as a parameter characterising these trajectories. The relative change in the reflected signal caused by a change in the glucose concentration is analysed depending on the distance between a probe radiation source and a detector. It is shown that the maximum relative change in the signal (about 7%) takes place for the source - detector separation in the range from 0.3 to 0.5 mm depending on the model parameters. (special issue devoted to multiple radiation scattering in random media)},
doi = {10.1070/QE2006V036N12ABEH013457},
journal = {Quantum Electronics (Woodbury, N.Y.)},
number = 12,
volume = 36,
place = {United States},
year = {Sun Dec 31 00:00:00 EST 2006},
month = {Sun Dec 31 00:00:00 EST 2006}
}