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Title: Optical coherent tomography measurements of the diffusion rate of water and drugs in an isolated and whole cornea

Abstract

The passive diffusion of drugs through the epithelial surfaces of an eye (the most widespread method for medical treatment of various diseases) is considered. The permeability of water and drugs through rabbit cornea was measured in the isolated cornea (separate from an eye) and in the whole cornea. The permeability coefficients of water and dexamethasone were estimated by the method of optical coherence tomography (OCT). Because multiple photon scattering introduces noise and distortions to the OCT signal, measurements were performed at depths up to 500 {mu}m where most likely single scattering of light occurs in cornea. It is shown that the permeability coefficients in the isolated and whole cornea strongly differ from each other. For example, the water permeability in the isolated and whole cornea is (7.09{+-}0.12)x10{sup -5} and (1.71{+-}0.51)x10{sup -5} cm s{sup -1}, respectively. (special issue devoted to multiple radiation scattering in random media)

Authors:
;  [1]
  1. University of Houston, Houston, Texas (United States)
Publication Date:
OSTI Identifier:
21456919
Resource Type:
Journal Article
Resource Relation:
Journal Name: Quantum Electronics (Woodbury, N.Y.); Journal Volume: 36; Journal Issue: 12; Other Information: DOI: 10.1070/QE2006v036n12ABEH013225
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CORNEA; DEXAMETHASONE; DIFFUSION; DRUGS; PERMEABILITY; PHOTONS; RABBITS; SCATTERING; SIGNALS; SURFACES; TOMOGRAPHY; VISIBLE RADIATION; WATER; ADRENAL HORMONES; ANIMALS; BODY; BOSONS; CORTICOSTEROIDS; DIAGNOSTIC TECHNIQUES; ELECTROMAGNETIC RADIATION; ELEMENTARY PARTICLES; EYES; FACE; GLUCOCORTICOIDS; HEAD; HORMONES; HYDROGEN COMPOUNDS; HYDROXY COMPOUNDS; KETONES; MAMMALS; MASSLESS PARTICLES; ORGANIC COMPOUNDS; ORGANS; OXYGEN COMPOUNDS; PHYSICAL PROPERTIES; PREGNANES; RADIATIONS; SENSE ORGANS; STEROID HORMONES; STEROIDS; VERTEBRATES

Citation Formats

Larin, Kirill V, and Ghosn, M G. Optical coherent tomography measurements of the diffusion rate of water and drugs in an isolated and whole cornea. United States: N. p., 2006. Web. doi:10.1070/QE2006V036N12ABEH013225.
Larin, Kirill V, & Ghosn, M G. Optical coherent tomography measurements of the diffusion rate of water and drugs in an isolated and whole cornea. United States. doi:10.1070/QE2006V036N12ABEH013225.
Larin, Kirill V, and Ghosn, M G. Sun . "Optical coherent tomography measurements of the diffusion rate of water and drugs in an isolated and whole cornea". United States. doi:10.1070/QE2006V036N12ABEH013225.
@article{osti_21456919,
title = {Optical coherent tomography measurements of the diffusion rate of water and drugs in an isolated and whole cornea},
author = {Larin, Kirill V and Ghosn, M G},
abstractNote = {The passive diffusion of drugs through the epithelial surfaces of an eye (the most widespread method for medical treatment of various diseases) is considered. The permeability of water and drugs through rabbit cornea was measured in the isolated cornea (separate from an eye) and in the whole cornea. The permeability coefficients of water and dexamethasone were estimated by the method of optical coherence tomography (OCT). Because multiple photon scattering introduces noise and distortions to the OCT signal, measurements were performed at depths up to 500 {mu}m where most likely single scattering of light occurs in cornea. It is shown that the permeability coefficients in the isolated and whole cornea strongly differ from each other. For example, the water permeability in the isolated and whole cornea is (7.09{+-}0.12)x10{sup -5} and (1.71{+-}0.51)x10{sup -5} cm s{sup -1}, respectively. (special issue devoted to multiple radiation scattering in random media)},
doi = {10.1070/QE2006V036N12ABEH013225},
journal = {Quantum Electronics (Woodbury, N.Y.)},
number = 12,
volume = 36,
place = {United States},
year = {Sun Dec 31 00:00:00 EST 2006},
month = {Sun Dec 31 00:00:00 EST 2006}
}
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  • Purpose: Magnetic resonance imaging/diffusion weighted-imaging (MRI/DWI)-guided high-dose-rate (HDR) brachytherapy and {sup 18}F-fluorodeoxyglucose (FDG) — positron emission tomography/computed tomography (PET/CT)-guided intensity modulated radiation therapy (IMRT) for the definitive treatment of cervical cancer is a novel treatment technique. The purpose of this study was to report our analysis of dose-volume parameters predicting gross tumor volume (GTV) control. Methods and Materials: We analyzed the records of 134 patients with International Federation of Gynecology and Obstetrics stages IB1-IVB cervical cancer treated with combined MRI-guided HDR and IMRT from July 2009 to July 2011. IMRT was targeted to the metabolic tumor volume and lymph nodesmore » by use of FDG-PET/CT simulation. The GTV for each HDR fraction was delineated by use of T2-weighted or apparent diffusion coefficient maps from diffusion-weighted sequences. The D100, D90, and Dmean delivered to the GTV from HDR and IMRT were summed to EQD2. Results: One hundred twenty-five patients received all irradiation treatment as planned, and 9 did not complete treatment. All 134 patients are included in this analysis. Treatment failure in the cervix occurred in 24 patients (18.0%). Patients with cervix failures had a lower D100, D90, and Dmean than those who did not experience failure in the cervix. The respective doses to the GTV were 41, 58, and 136 Gy for failures compared with 67, 99, and 236 Gy for those who did not experience failure (P<.001). Probit analysis estimated the minimum D100, D90, and Dmean doses required for ≥90% local control to be 69, 98, and 260 Gy (P<.001). Conclusions: Total dose delivered to the GTV from combined MRI-guided HDR and PET/CT-guided IMRT is highly correlated with local tumor control. The findings can be directly applied in the clinic for dose adaptation to maximize local control.« less