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Title: Optical coherent tomography measurements of the diffusion rate of water and drugs in an isolated and whole cornea

Abstract

The passive diffusion of drugs through the epithelial surfaces of an eye (the most widespread method for medical treatment of various diseases) is considered. The permeability of water and drugs through rabbit cornea was measured in the isolated cornea (separate from an eye) and in the whole cornea. The permeability coefficients of water and dexamethasone were estimated by the method of optical coherence tomography (OCT). Because multiple photon scattering introduces noise and distortions to the OCT signal, measurements were performed at depths up to 500 {mu}m where most likely single scattering of light occurs in cornea. It is shown that the permeability coefficients in the isolated and whole cornea strongly differ from each other. For example, the water permeability in the isolated and whole cornea is (7.09{+-}0.12)x10{sup -5} and (1.71{+-}0.51)x10{sup -5} cm s{sup -1}, respectively. (special issue devoted to multiple radiation scattering in random media)

Authors:
;  [1]
  1. University of Houston, Houston, Texas (United States)
Publication Date:
OSTI Identifier:
21456919
Resource Type:
Journal Article
Resource Relation:
Journal Name: Quantum Electronics (Woodbury, N.Y.); Journal Volume: 36; Journal Issue: 12; Other Information: DOI: 10.1070/QE2006v036n12ABEH013225
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CORNEA; DEXAMETHASONE; DIFFUSION; DRUGS; PERMEABILITY; PHOTONS; RABBITS; SCATTERING; SIGNALS; SURFACES; TOMOGRAPHY; VISIBLE RADIATION; WATER; ADRENAL HORMONES; ANIMALS; BODY; BOSONS; CORTICOSTEROIDS; DIAGNOSTIC TECHNIQUES; ELECTROMAGNETIC RADIATION; ELEMENTARY PARTICLES; EYES; FACE; GLUCOCORTICOIDS; HEAD; HORMONES; HYDROGEN COMPOUNDS; HYDROXY COMPOUNDS; KETONES; MAMMALS; MASSLESS PARTICLES; ORGANIC COMPOUNDS; ORGANS; OXYGEN COMPOUNDS; PHYSICAL PROPERTIES; PREGNANES; RADIATIONS; SENSE ORGANS; STEROID HORMONES; STEROIDS; VERTEBRATES

Citation Formats

Larin, Kirill V, and Ghosn, M G. Optical coherent tomography measurements of the diffusion rate of water and drugs in an isolated and whole cornea. United States: N. p., 2006. Web. doi:10.1070/QE2006V036N12ABEH013225.
Larin, Kirill V, & Ghosn, M G. Optical coherent tomography measurements of the diffusion rate of water and drugs in an isolated and whole cornea. United States. doi:10.1070/QE2006V036N12ABEH013225.
Larin, Kirill V, and Ghosn, M G. Sun . "Optical coherent tomography measurements of the diffusion rate of water and drugs in an isolated and whole cornea". United States. doi:10.1070/QE2006V036N12ABEH013225.
@article{osti_21456919,
title = {Optical coherent tomography measurements of the diffusion rate of water and drugs in an isolated and whole cornea},
author = {Larin, Kirill V and Ghosn, M G},
abstractNote = {The passive diffusion of drugs through the epithelial surfaces of an eye (the most widespread method for medical treatment of various diseases) is considered. The permeability of water and drugs through rabbit cornea was measured in the isolated cornea (separate from an eye) and in the whole cornea. The permeability coefficients of water and dexamethasone were estimated by the method of optical coherence tomography (OCT). Because multiple photon scattering introduces noise and distortions to the OCT signal, measurements were performed at depths up to 500 {mu}m where most likely single scattering of light occurs in cornea. It is shown that the permeability coefficients in the isolated and whole cornea strongly differ from each other. For example, the water permeability in the isolated and whole cornea is (7.09{+-}0.12)x10{sup -5} and (1.71{+-}0.51)x10{sup -5} cm s{sup -1}, respectively. (special issue devoted to multiple radiation scattering in random media)},
doi = {10.1070/QE2006V036N12ABEH013225},
journal = {Quantum Electronics (Woodbury, N.Y.)},
number = 12,
volume = 36,
place = {United States},
year = {Sun Dec 31 00:00:00 EST 2006},
month = {Sun Dec 31 00:00:00 EST 2006}
}