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Title: Optical clearing of the eye sclera in vivo caused by glucose

Abstract

Changes in the optical properties of the eye sclera of a laboratory animal (rabbit) caused by the noninvasive administration of an immersion agent (aqueous glucose solution) into sclera are studied experimentally in vivo by the method of reflection spectroscopy and simulated numerically. The diffusion coefficients of glucose and water in sclera are estimated from simulations of optical clearing within the framework of the developed model as h(5.4{+-}0.1)x10{sup -7} and (5.8{+-}0.2)x10{sup -7} cm{sup 2} s{sup -1}, respectively. Experiments showed that the application of the glucose solution on the sclera allows the efficient control of its optical properties, which makes it possible to deliver the laser energy to internal eye tissues without considerable attenuation and distortions of its spatial distribution in laser diagnostics and therapy. (special issue devoted to multiple radiation scattering in random media)

Authors:
; ; ;  [1]
  1. Department of Optics and Biomedical Physics, N.G.Chernyshevskii Saratov State University (Russian Federation)
Publication Date:
OSTI Identifier:
21456918
Resource Type:
Journal Article
Resource Relation:
Journal Name: Quantum Electronics (Woodbury, N.Y.); Journal Volume: 36; Journal Issue: 12; Other Information: DOI: 10.1070/QE2006v036n12ABEH013337
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; AQUEOUS SOLUTIONS; DIAGNOSTIC TECHNIQUES; DIFFUSION; EYES; GLUCOSE; IN VIVO; LABORATORY ANIMALS; LASERS; OPTICAL PROPERTIES; RABBITS; REFLECTION; SIMULATION; SPATIAL DISTRIBUTION; SPECTROSCOPY; THERAPY; ALDEHYDES; ANIMALS; BODY; CARBOHYDRATES; DISPERSIONS; DISTRIBUTION; FACE; HEAD; HEXOSES; HOMOGENEOUS MIXTURES; MAMMALS; MEDICINE; MIXTURES; MONOSACCHARIDES; ORGANIC COMPOUNDS; ORGANS; PHYSICAL PROPERTIES; SACCHARIDES; SENSE ORGANS; SOLUTIONS; VERTEBRATES

Citation Formats

Genina, Elina A, Bashkatov, A N, Sinichkin, Yu P, and Tuchin, Valerii V. Optical clearing of the eye sclera in vivo caused by glucose. United States: N. p., 2006. Web. doi:10.1070/QE2006V036N12ABEH013337.
Genina, Elina A, Bashkatov, A N, Sinichkin, Yu P, & Tuchin, Valerii V. Optical clearing of the eye sclera in vivo caused by glucose. United States. doi:10.1070/QE2006V036N12ABEH013337.
Genina, Elina A, Bashkatov, A N, Sinichkin, Yu P, and Tuchin, Valerii V. Sun . "Optical clearing of the eye sclera in vivo caused by glucose". United States. doi:10.1070/QE2006V036N12ABEH013337.
@article{osti_21456918,
title = {Optical clearing of the eye sclera in vivo caused by glucose},
author = {Genina, Elina A and Bashkatov, A N and Sinichkin, Yu P and Tuchin, Valerii V},
abstractNote = {Changes in the optical properties of the eye sclera of a laboratory animal (rabbit) caused by the noninvasive administration of an immersion agent (aqueous glucose solution) into sclera are studied experimentally in vivo by the method of reflection spectroscopy and simulated numerically. The diffusion coefficients of glucose and water in sclera are estimated from simulations of optical clearing within the framework of the developed model as h(5.4{+-}0.1)x10{sup -7} and (5.8{+-}0.2)x10{sup -7} cm{sup 2} s{sup -1}, respectively. Experiments showed that the application of the glucose solution on the sclera allows the efficient control of its optical properties, which makes it possible to deliver the laser energy to internal eye tissues without considerable attenuation and distortions of its spatial distribution in laser diagnostics and therapy. (special issue devoted to multiple radiation scattering in random media)},
doi = {10.1070/QE2006V036N12ABEH013337},
journal = {Quantum Electronics (Woodbury, N.Y.)},
number = 12,
volume = 36,
place = {United States},
year = {Sun Dec 31 00:00:00 EST 2006},
month = {Sun Dec 31 00:00:00 EST 2006}
}