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Title: Light-oxygen effect in cells and its potential applications in tumour therapy (review)

Abstract

The light-oxygen effect (POE) represents damage (and at low optical doses, activation) of cells by photogeneration of molecular singlet oxygen from O{sub 2} dissolved in cells, in accordance with the reaction: {sup 3}O{sub 2}+h{nu}{yields}{sup 1}O{sub 2}{yields} biological effect. The phases of evolution of the LOE are similar to the phases, observed in cell experiments, of the photodynamic effect (PDE) the mechanism of which is the basis of the familiar method of photodynamic cancer therapy. The reported proofs of the occurrence of the LOE are in the form of detailed spectra of the biological action of optical radiation on cells recorded in four spectral intervals with the aid of tunable lasers. Allowances are made for the relationships governing a new type of cell excitation, associated with reversible structural transitions in the biomembrane. A demonstration is reported of the same efficiency of cw and pulsed irradiation. An analysis is made of the reasons why the optical doses initiating the PDE and the LOE are comparable. The results are given of the first experimental applications of the LOE in tumour therapy. Identification of the primary photoacceptor (O{sub 2}) in cell biostimulation and photodestruction provides a scientific basis for the development of low-intensity lasermore » light-oxygen cancer therapy methods. (lasers in medicine)« less

Authors:
 [1];  [2]
  1. P.N. Lebedev Physics Institute, Russian Academy of Sciences, Moscow (Russian Federation)
  2. N.N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow (Russian Federation)
Publication Date:
OSTI Identifier:
21437861
Resource Type:
Journal Article
Journal Name:
Quantum Electronics (Woodbury, N.Y.)
Additional Journal Information:
Journal Volume: 29; Journal Issue: 12; Other Information: DOI: 10.1070/QE1999v029n12ABEH001629; Journal ID: ISSN 1063-7818
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BIOLOGICAL EFFECTS; EFFICIENCY; EXCITATION; LASERS; NEOPLASMS; OXYGEN; PHOTON BEAMS; PULSED IRRADIATION; RADIATION DOSES; REVIEWS; SPECTRA; THERAPY; VISIBLE RADIATION; BEAMS; DISEASES; DOCUMENT TYPES; DOSES; ELECTROMAGNETIC RADIATION; ELEMENTS; ENERGY-LEVEL TRANSITIONS; IRRADIATION; MEDICINE; NONMETALS; RADIATIONS

Citation Formats

Zakharov, S D, and Ivanov, Andrei V. Light-oxygen effect in cells and its potential applications in tumour therapy (review). United States: N. p., 1999. Web. doi:10.1070/QE1999V029N12ABEH001629.
Zakharov, S D, & Ivanov, Andrei V. Light-oxygen effect in cells and its potential applications in tumour therapy (review). United States. doi:10.1070/QE1999V029N12ABEH001629.
Zakharov, S D, and Ivanov, Andrei V. Fri . "Light-oxygen effect in cells and its potential applications in tumour therapy (review)". United States. doi:10.1070/QE1999V029N12ABEH001629.
@article{osti_21437861,
title = {Light-oxygen effect in cells and its potential applications in tumour therapy (review)},
author = {Zakharov, S D and Ivanov, Andrei V},
abstractNote = {The light-oxygen effect (POE) represents damage (and at low optical doses, activation) of cells by photogeneration of molecular singlet oxygen from O{sub 2} dissolved in cells, in accordance with the reaction: {sup 3}O{sub 2}+h{nu}{yields}{sup 1}O{sub 2}{yields} biological effect. The phases of evolution of the LOE are similar to the phases, observed in cell experiments, of the photodynamic effect (PDE) the mechanism of which is the basis of the familiar method of photodynamic cancer therapy. The reported proofs of the occurrence of the LOE are in the form of detailed spectra of the biological action of optical radiation on cells recorded in four spectral intervals with the aid of tunable lasers. Allowances are made for the relationships governing a new type of cell excitation, associated with reversible structural transitions in the biomembrane. A demonstration is reported of the same efficiency of cw and pulsed irradiation. An analysis is made of the reasons why the optical doses initiating the PDE and the LOE are comparable. The results are given of the first experimental applications of the LOE in tumour therapy. Identification of the primary photoacceptor (O{sub 2}) in cell biostimulation and photodestruction provides a scientific basis for the development of low-intensity laser light-oxygen cancer therapy methods. (lasers in medicine)},
doi = {10.1070/QE1999V029N12ABEH001629},
journal = {Quantum Electronics (Woodbury, N.Y.)},
issn = {1063-7818},
number = 12,
volume = 29,
place = {United States},
year = {1999},
month = {12}
}