Dosimetric Effects of Air Pockets Around High-Dose Rate Brachytherapy Vaginal Cylinders

Richardson, Susan; Palaniswaamy, Geethpriya; Grigsby, Perry W

doi:10.1016/j.ijrobp.2009.11.004

Title: Dosimetric Effects of Air Pockets Around High-Dose Rate Brachytherapy Vaginal Cylinders

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Abstract

Purpose: Most physicians use a single-channel vaginal cylinder for postoperative endometrial cancer brachytherapy. Recent published data have identified air pockets between the vaginal cylinders and the vaginal mucosa. The purpose of this research was to evaluate the incidence, size, and dosimetric effects of these air pockets. Methods and Materials: 25 patients receiving postoperative vaginal cuff brachytherapy with a high-dose rate vaginal cylinders were enrolled in this prospective data collection study. Patients were treated with 6 fractions of 200 to 400 cGy per fraction prescribed at 5 mm depth. Computed tomography simulation for brachytherapy treatment planning was performed for each fraction. The quantity, volume, and dosimetric impact of the air pockets surrounding the cylinder were quantified. Results: In 25 patients, a total of 90 air pockets were present in 150 procedures (60%). Five patients had no air pockets present during any of their treatments. The average number of air pockets per patient was 3.6, with the average total air pocket volume being 0.34 cm{sup 3} (range, 0.01-1.32 cm{sup 3}). The average dose reduction to the vaginal mucosa at the air pocket was 27% (range, 9-58%). Ten patients had no air pockets on their first fraction but air pockets occurred in subsequentmore »« less

Authors:

Richardson, Susan ^[1]; Palaniswaamy, Geethpriya; Grigsby, Perry W ^[1]

Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (United States)

Publication Date:: Wed Sep 01 00:00:00 EDT 2010

OSTI Identifier:: 21436165

Resource Type:: Journal Article

Journal Name:: International Journal of Radiation Oncology, Biology and Physics

Additional Journal Information:: Journal Volume: 78; Journal Issue: 1; Other Information: DOI: 10.1016/j.ijrobp.2009.11.004; PII: S0360-3016(09)03453-1; Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Journal ID: ISSN 0360-3016

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; AIR; BRACHYTHERAPY; COMPUTERIZED TOMOGRAPHY; CYLINDERS; FEMALE GENITALS; MUCOUS MEMBRANES; NEOPLASMS; RADIATION DOSES; SIMULATION; BODY; DIAGNOSTIC TECHNIQUES; DISEASES; DOSES; FLUIDS; GASES; MEDICINE; MEMBRANES; NUCLEAR MEDICINE; ORGANS; RADIOLOGY; RADIOTHERAPY; THERAPY; TOMOGRAPHY

Citation Formats


                    Richardson, Susan, Palaniswaamy, Geethpriya, and Grigsby, Perry W. Dosimetric Effects of Air Pockets Around High-Dose Rate Brachytherapy Vaginal Cylinders.  United States: N. p., 2010. 
        Web.  doi:10.1016/j.ijrobp.2009.11.004.

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                    Richardson, Susan, Palaniswaamy, Geethpriya, & Grigsby, Perry W. Dosimetric Effects of Air Pockets Around High-Dose Rate Brachytherapy Vaginal Cylinders.  United States.  https://doi.org/10.1016/j.ijrobp.2009.11.004

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                    Richardson, Susan, Palaniswaamy, Geethpriya, and Grigsby, Perry W. 2010.  
        "Dosimetric Effects of Air Pockets Around High-Dose Rate Brachytherapy Vaginal Cylinders".  United States.  https://doi.org/10.1016/j.ijrobp.2009.11.004.

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@article{osti_21436165,

  title        = {Dosimetric Effects of Air Pockets Around High-Dose Rate Brachytherapy Vaginal Cylinders},

  author       = {Richardson, Susan and Palaniswaamy, Geethpriya and Grigsby, Perry W},

  abstractNote = {Purpose: Most physicians use a single-channel vaginal cylinder for postoperative endometrial cancer brachytherapy. Recent published data have identified air pockets between the vaginal cylinders and the vaginal mucosa. The purpose of this research was to evaluate the incidence, size, and dosimetric effects of these air pockets. Methods and Materials: 25 patients receiving postoperative vaginal cuff brachytherapy with a high-dose rate vaginal cylinders were enrolled in this prospective data collection study. Patients were treated with 6 fractions of 200 to 400 cGy per fraction prescribed at 5 mm depth. Computed tomography simulation for brachytherapy treatment planning was performed for each fraction. The quantity, volume, and dosimetric impact of the air pockets surrounding the cylinder were quantified. Results: In 25 patients, a total of 90 air pockets were present in 150 procedures (60%). Five patients had no air pockets present during any of their treatments. The average number of air pockets per patient was 3.6, with the average total air pocket volume being 0.34 cm{sup 3} (range, 0.01-1.32 cm{sup 3}). The average dose reduction to the vaginal mucosa at the air pocket was 27% (range, 9-58%). Ten patients had no air pockets on their first fraction but air pockets occurred in subsequent fractions. Conclusion: Air pockets between high-dose rate vaginal cylinder applicators and the vaginal mucosa are present in the majority of fractions of therapy, and their presence varies from patient to patient and fraction to fraction. The existence of air pockets results in reduced radiation dose to the vaginal mucosa.},

  doi          = {10.1016/j.ijrobp.2009.11.004},

  url          = {https://www.osti.gov/biblio/21436165},
  journal      = {International Journal of Radiation Oncology, Biology and Physics},

  issn         = {0360-3016},

  number       = 1,

  volume       = 78,

  place        = {United States},

  year         = {Wed Sep 01 00:00:00 EDT 2010},

  month        = {Wed Sep 01 00:00:00 EDT 2010}

}

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