skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Tolerance of Arteries to Microplanar X-Ray Beams

Abstract

Purpose: The purpose is to evaluate effects of a new radiotherapy protocol, microbeam radiation therapy, on the artery wall. In previous studies on animal models, it was shown that capillaries recover well from hectogray doses of X-rays delivered in arrays of narrow ({<=}50 {mu}m) beams with a minimum spacing of 200 {mu}m. Here, short- and long-term effects of comparable microplanar beam configurations on the saphenous artery of the mouse hind leg were analyzed in situ by use of nonlinear optics and compared with histopathologic findings. Methods and Materials: The left hind leg of normal mice including the saphenous artery was irradiated by an array of 26 microbeams of synchrotron X-rays (50 {mu}m wide, spaced 400 {mu}m on center) with peak entrance doses of 312 Gy and 2,000 Gy. Results: The artery remained patent, but narrow arterial smooth muscle cell layer segments that were in the microplanar beam paths became atrophic and fibrotic in a dose-dependent pattern. The wide tunica media segments between those paths hypertrophied, as observed in situ by two-photon microscopy and histopathologically. Conclusions: Clinical risks of long-delayed disruption or occlusion of nontargeted arteries from microbeam radiation therapy will prove less than corresponding risks from broad-beam radiosurgery, especially ifmore » peak doses are kept below 3 hectograys.« less

Authors:
 [1];  [2];  [3];  [4];  [5]
  1. European Synchrotron Radiation Facility, Grenoble (France)
  2. Department of Oncology and Pathology, Karolinska Institutet, Stockholm (Sweden)
  3. INSERM U836, Institute of Neuroscience Grenoble (France)
  4. CNRS UMR 5588, Physical Spectroscopy, Grenoble (France)
  5. Institute of Pathology, University of Bern (Switzerland)
Publication Date:
OSTI Identifier:
21436128
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 77; Journal Issue: 5; Other Information: DOI: 10.1016/j.ijrobp.2010.02.019; PII: S0360-3016(10)00253-1; Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ARTERIES; LEGS; MICE; RADIOTHERAPY; X RADIATION; ANIMALS; BLOOD VESSELS; BODY; CARDIOVASCULAR SYSTEM; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; LIMBS; MAMMALS; MEDICINE; NUCLEAR MEDICINE; ORGANS; RADIATIONS; RADIOLOGY; RODENTS; THERAPY; VERTEBRATES

Citation Formats

Sanden, Boudewijn van der, E-mail: Boudewijn.vandersanden@ujf-grenoble.f, Braeuer-Krisch, Elke, Siegbahn, Erik Albert, Ricard, Clement, Vial, Jean-Claude, and Laissue, Jean. Tolerance of Arteries to Microplanar X-Ray Beams. United States: N. p., 2010. Web. doi:10.1016/j.ijrobp.2010.02.019.
Sanden, Boudewijn van der, E-mail: Boudewijn.vandersanden@ujf-grenoble.f, Braeuer-Krisch, Elke, Siegbahn, Erik Albert, Ricard, Clement, Vial, Jean-Claude, & Laissue, Jean. Tolerance of Arteries to Microplanar X-Ray Beams. United States. doi:10.1016/j.ijrobp.2010.02.019.
Sanden, Boudewijn van der, E-mail: Boudewijn.vandersanden@ujf-grenoble.f, Braeuer-Krisch, Elke, Siegbahn, Erik Albert, Ricard, Clement, Vial, Jean-Claude, and Laissue, Jean. Sun . "Tolerance of Arteries to Microplanar X-Ray Beams". United States. doi:10.1016/j.ijrobp.2010.02.019.
@article{osti_21436128,
title = {Tolerance of Arteries to Microplanar X-Ray Beams},
author = {Sanden, Boudewijn van der, E-mail: Boudewijn.vandersanden@ujf-grenoble.f and Braeuer-Krisch, Elke and Siegbahn, Erik Albert and Ricard, Clement and Vial, Jean-Claude and Laissue, Jean},
abstractNote = {Purpose: The purpose is to evaluate effects of a new radiotherapy protocol, microbeam radiation therapy, on the artery wall. In previous studies on animal models, it was shown that capillaries recover well from hectogray doses of X-rays delivered in arrays of narrow ({<=}50 {mu}m) beams with a minimum spacing of 200 {mu}m. Here, short- and long-term effects of comparable microplanar beam configurations on the saphenous artery of the mouse hind leg were analyzed in situ by use of nonlinear optics and compared with histopathologic findings. Methods and Materials: The left hind leg of normal mice including the saphenous artery was irradiated by an array of 26 microbeams of synchrotron X-rays (50 {mu}m wide, spaced 400 {mu}m on center) with peak entrance doses of 312 Gy and 2,000 Gy. Results: The artery remained patent, but narrow arterial smooth muscle cell layer segments that were in the microplanar beam paths became atrophic and fibrotic in a dose-dependent pattern. The wide tunica media segments between those paths hypertrophied, as observed in situ by two-photon microscopy and histopathologically. Conclusions: Clinical risks of long-delayed disruption or occlusion of nontargeted arteries from microbeam radiation therapy will prove less than corresponding risks from broad-beam radiosurgery, especially if peak doses are kept below 3 hectograys.},
doi = {10.1016/j.ijrobp.2010.02.019},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 5,
volume = 77,
place = {United States},
year = {2010},
month = {8}
}