skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: A Comparison of Four- Versus Three-Pass Transjugular Biopsy Using a 19-G Tru-Cut Needle and a Randomized Study Using a Cassette to Prevent Biopsy Fragmentation

Abstract

Recently, it has been shown that transjugular liver biopsy (TJLB) with three passes gives comparable specimens to percutaneous liver biopsy (PLB). The aim of this study was to evaluate the adequacy of TJLB using four passes in a consecutive series of patients, and whether using a supportive cassette can prevent fragmentation. One hundred consecutive TJLBs in 92 patients (48 transplanted), always using four passes (19-G Tru-Cut), were compared to three-pass TJLBs. The four-pass TJLB specimens were randomized at a 1:1 ratio of liver cores placed in a cassette versus not. The four-pass TJLBs, compared to three-pass TJLBs, resulted in better specimens for length ({>=}25 mm: 50% vs. 35%; p = 0.026) and number of complete portal tracts (CPTs) ({>=}11: 40% vs. 26%; p = 0.027), without a higher complication rate. The four-pass TJLB with {>=}11 CPTs had a median length of 27 mm, and 57% of them longer than 28 mm contained {>=}11 CPTs. Putting the liver biopsy cores into a cassette did not improve the fragmentation rate or adequacy of the specimen (length and number of CPTs) of TJLB. We conclude that at least four passes with TJLB should be performed when liver specimens are needed for grading andmore » staging. Using a supportive cassette did not reduce fragmentation.« less

Authors:
; ; ;  [1];  [2]; ; ;  [1];  [2];  [1]
  1. Royal Free Hospital, Liver Transplantation and Hepatobiliary Medicine (United Kingdom)
  2. Royal Free Hospital, Department of Histopathology (United Kingdom)
Publication Date:
OSTI Identifier:
21428565
Resource Type:
Journal Article
Journal Name:
Cardiovascular and Interventional Radiology
Additional Journal Information:
Journal Volume: 32; Journal Issue: 3; Other Information: DOI: 10.1007/s00270-008-9412-7; Copyright (c) 2009 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Article Copyright (c) 2008 Springer Science+Business Media, LLC; Journal ID: ISSN 0174-1551
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BIOPSY; FRAGMENTATION; LIVER; BODY; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; GLANDS; ORGANS

Citation Formats

Vibhakorn, Shusang, Cholongitas, Evangelos, Kalambokis, George, Manousou, Pinelopi, Quaglia, Alberto, Marelli, Laura, Senzolo, Marco, Patch, David, Dhillon, Amar, and Burroughs, Andrew K., E-mail: Andrew.Burroughs@royalfree.nhs.u. A Comparison of Four- Versus Three-Pass Transjugular Biopsy Using a 19-G Tru-Cut Needle and a Randomized Study Using a Cassette to Prevent Biopsy Fragmentation. United States: N. p., 2009. Web. doi:10.1007/S00270-008-9412-7.
Vibhakorn, Shusang, Cholongitas, Evangelos, Kalambokis, George, Manousou, Pinelopi, Quaglia, Alberto, Marelli, Laura, Senzolo, Marco, Patch, David, Dhillon, Amar, & Burroughs, Andrew K., E-mail: Andrew.Burroughs@royalfree.nhs.u. A Comparison of Four- Versus Three-Pass Transjugular Biopsy Using a 19-G Tru-Cut Needle and a Randomized Study Using a Cassette to Prevent Biopsy Fragmentation. United States. doi:10.1007/S00270-008-9412-7.
Vibhakorn, Shusang, Cholongitas, Evangelos, Kalambokis, George, Manousou, Pinelopi, Quaglia, Alberto, Marelli, Laura, Senzolo, Marco, Patch, David, Dhillon, Amar, and Burroughs, Andrew K., E-mail: Andrew.Burroughs@royalfree.nhs.u. Fri . "A Comparison of Four- Versus Three-Pass Transjugular Biopsy Using a 19-G Tru-Cut Needle and a Randomized Study Using a Cassette to Prevent Biopsy Fragmentation". United States. doi:10.1007/S00270-008-9412-7.
@article{osti_21428565,
title = {A Comparison of Four- Versus Three-Pass Transjugular Biopsy Using a 19-G Tru-Cut Needle and a Randomized Study Using a Cassette to Prevent Biopsy Fragmentation},
author = {Vibhakorn, Shusang and Cholongitas, Evangelos and Kalambokis, George and Manousou, Pinelopi and Quaglia, Alberto and Marelli, Laura and Senzolo, Marco and Patch, David and Dhillon, Amar and Burroughs, Andrew K., E-mail: Andrew.Burroughs@royalfree.nhs.u},
abstractNote = {Recently, it has been shown that transjugular liver biopsy (TJLB) with three passes gives comparable specimens to percutaneous liver biopsy (PLB). The aim of this study was to evaluate the adequacy of TJLB using four passes in a consecutive series of patients, and whether using a supportive cassette can prevent fragmentation. One hundred consecutive TJLBs in 92 patients (48 transplanted), always using four passes (19-G Tru-Cut), were compared to three-pass TJLBs. The four-pass TJLB specimens were randomized at a 1:1 ratio of liver cores placed in a cassette versus not. The four-pass TJLBs, compared to three-pass TJLBs, resulted in better specimens for length ({>=}25 mm: 50% vs. 35%; p = 0.026) and number of complete portal tracts (CPTs) ({>=}11: 40% vs. 26%; p = 0.027), without a higher complication rate. The four-pass TJLB with {>=}11 CPTs had a median length of 27 mm, and 57% of them longer than 28 mm contained {>=}11 CPTs. Putting the liver biopsy cores into a cassette did not improve the fragmentation rate or adequacy of the specimen (length and number of CPTs) of TJLB. We conclude that at least four passes with TJLB should be performed when liver specimens are needed for grading and staging. Using a supportive cassette did not reduce fragmentation.},
doi = {10.1007/S00270-008-9412-7},
journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 3,
volume = 32,
place = {United States},
year = {2009},
month = {5}
}