skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Preliminary Assessment of the Functional Fitness of Alpha Emitter At-211 for Radiotherapy

Abstract

The functional fitness of the alpha-emitter At-211 for radiotherapy of the thyroid gland cancer is evaluated. Radiation doses are calculated using the MIRD method and previously obtained pharmacokinetic data for At-211 in isotonic solution.

Authors:
; ; ; ;  [1]; ;  [2];  [3]
  1. Skobetsyn Institute of Nuclear Physics, Lomonosov Moscow State University, Moscow 119991 (Russian Federation)
  2. Lomonosov Moscow State University, Physical Department, Moscow 119991 (Russian Federation)
  3. Institute of Biophysics, State Research Center of Russia, Zhivopisnaya, 46, 123182 Moscow (Russian Federation)
Publication Date:
OSTI Identifier:
21366914
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1204; Journal Issue: 1; Conference: 5. international summer school on nuclear physics methods and accelerators in biology and medicine, Bratislava (Slovakia), 6-15 Jul 2009; Other Information: DOI: 10.1063/1.3295650; (c) 2009 American Institute of Physics
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ALPHA DECAY; ASTATINE 211; ISOTONIC SOLUTIONS; NEOPLASMS; RADIATION DOSES; RADIOTHERAPY; THYROID; ALPHA DECAY RADIOISOTOPES; ASTATINE ISOTOPES; BETA DECAY RADIOISOTOPES; BODY; DECAY; DISEASES; DISPERSIONS; DOSES; ELECTRON CAPTURE RADIOISOTOPES; ENDOCRINE GLANDS; GLANDS; HEAVY NUCLEI; HOMOGENEOUS MIXTURES; HOURS LIVING RADIOISOTOPES; ISOTOPES; MEDICINE; MIXTURES; NUCLEAR DECAY; NUCLEAR MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPES; RADIOLOGY; SOLUTIONS; THERAPY

Citation Formats

Eremenko, D. O., Fotina, O. V., Platonov, S. Yu., Subbotina, E. A., Yuminov, O. A., Pankratova, T. V., Sirotkina, E. B., and Tultaev, A. V.. Preliminary Assessment of the Functional Fitness of Alpha Emitter At-211 for Radiotherapy. United States: N. p., 2010. Web. doi:10.1063/1.3295650.
Eremenko, D. O., Fotina, O. V., Platonov, S. Yu., Subbotina, E. A., Yuminov, O. A., Pankratova, T. V., Sirotkina, E. B., & Tultaev, A. V.. Preliminary Assessment of the Functional Fitness of Alpha Emitter At-211 for Radiotherapy. United States. doi:10.1063/1.3295650.
Eremenko, D. O., Fotina, O. V., Platonov, S. Yu., Subbotina, E. A., Yuminov, O. A., Pankratova, T. V., Sirotkina, E. B., and Tultaev, A. V.. Tue . "Preliminary Assessment of the Functional Fitness of Alpha Emitter At-211 for Radiotherapy". United States. doi:10.1063/1.3295650.
@article{osti_21366914,
title = {Preliminary Assessment of the Functional Fitness of Alpha Emitter At-211 for Radiotherapy},
author = {Eremenko, D. O. and Fotina, O. V. and Platonov, S. Yu. and Subbotina, E. A. and Yuminov, O. A. and Pankratova, T. V. and Sirotkina, E. B. and Tultaev, A. V.},
abstractNote = {The functional fitness of the alpha-emitter At-211 for radiotherapy of the thyroid gland cancer is evaluated. Radiation doses are calculated using the MIRD method and previously obtained pharmacokinetic data for At-211 in isotonic solution.},
doi = {10.1063/1.3295650},
journal = {AIP Conference Proceedings},
number = 1,
volume = 1204,
place = {United States},
year = {Tue Jan 05 00:00:00 EST 2010},
month = {Tue Jan 05 00:00:00 EST 2010}
}
  • By means of solid-state counter techniques the intensity of the alpha groups from Bi/sup 211/, Po/sup 211/, Rn/sup 219/, and Ra/sup 223/ is measured. In particular the branching BETA /( alpha + BETA ) in Bi/sup 211/ is measured as (0.29 plus or minus 0.01) x 10/sup -2/. (auth)
  • A recent treatment of first-forbidden {beta}{sup {minus}} decay in the lead region is extended to {beta}{sup +} decay and electron capture. The modified Kuo-Herling shell-model interaction recently described by Warburton and Brown is used to calculate wave functions and observables for {sup 211}Po. The log{ital f}{sub 0}{ital t} values for the {sup 211}Bi(9/2{sup {minus}}){r arrow}{sup 211}Po(9/2{sup +}) {beta}{sup {minus}} transition and the electron capture of {sup 211}At(9/2{sup {minus}}) into the 9/2 {sub 1}{sup +} and 11/2 {sub 1}{sup +} states of {sup 211}Po are predicted to be 6.008, 5.891, and 5.850 as compared to the experimental values of 6.026{plus minus}0.017,more » 5.960{plus minus}0.008, and 5.831{plus minus}0.090, respectively. The wave functions and spectrum of {sup 211}Po are calculated in the Kuo-Herling model space. The yrast spectrum is presented for comparison to anticipated results from fusion-evaporation reaction studies. The experimental {sup 210}Po({ital d},{ital p}){sup 211}Po spectroscopic factors are quite accurately reproduced.« less
  • Elucidating functions of commensal microbial genes in the mammalian gut is challenging because many commensals are recalcitrant to laboratory cultivation and genetic manipulation. We present Temporal FUnctional Metagenomics sequencing (TFUMseq), a platform to functionally mine bacterial genomes for genes that contribute to fitness of commensal bacteria in vivo. Our approach uses metagenomic DNA to construct large-scale heterologous expression libraries that are tracked over time in vivo by deep sequencing and computational methods. To demonstrate our approach, we built a TFUMseq plasmid library using the gut commensal Bacteroides thetaiotaomicron (Bt) and introduced Escherichia coli carrying this library into germfree mice. Populationmore » dynamics of library clones revealed Bt genes conferring significant fitness advantages in E. coli over time, including carbohydrate utilization genes, with a Bt galactokinase central to early colonization, and subsequent dominance by a Bt glycoside hydrolase enabling sucrose metabolism coupled with co-evolution of the plasmid library and E. coli genome driving increased galactose utilization. Here, our findings highlight the utility of functional metagenomics for engineering commensal bacteria with improved properties, including expanded colonization capabilities in vivo.« less
  • Treatment of micrometastases of HX34 human melanoma grown as xenografts in nude mice represents an advanced stage of preclinical investigations concerning targeted radiotherapy of this neoplasm using 3,7-(dimethylamino)phenazathionium chloride methylene blue (MTB) labeled with astatine-211 (211At) (alpha-particle emitter). The therapeutic effectiveness of 211At-MTB administered i.v. was determined by a lung colony assay combined with a search for metastases to organs other than the lungs. A single dose of 211At-MTB lowered the HX34 cell surviving fraction in lungs to below 10% almost independently of the time interval between cell inoculation and radioisotope injection and of 211At-MTB radioactivity within its investigated range.more » Radiation dose and the time of its administration did, however, influence the size of lung colonies. In contrast, the efficacy of 211At-MTB treatment as assessed by both surviving fraction and colony size was significantly dependent on a number of HX34 cells inoculated initially into mice. These results are explained by a short range of alpha-particles emitted by 211At and a mechanism of growth of lung colonies from tumor cells circulating with blood and blocking lung capillaries. Metastases in organs other than lungs and characteristic of control animals were not found in mice treated with 211At-MTB. The high therapeutic efficacy achieved proved that 211At-MTB is a very efficient scavenger of single melanoma cells distributed through blood and micrometastases with sizes below the limit of clinical detection.« less