X-ray elastography: Modification of x-ray phase contrast images using ultrasonic radiation pressure
- Department of Chemistry, Brown University, Providence, Rhode Island 02912 (United States)
- Liver Research Center, Warren Alpert School of Medicine and Rhode Island Hospital, Brown University, Providence, Rhode Island 02912 (United States)
The high resolution characteristic of in-line x-ray phase contrast imaging can be used in conjunction with directed ultrasound to detect small displacements in soft tissue generated by differential acoustic radiation pressure. The imaging method is based on subtraction of two x-ray images, the first image taken with, and the second taken without the presence of ultrasound. The subtraction enhances phase contrast features and, to a large extent, removes absorption contrast so that differential movement of tissues with different acoustic impedances or relative ultrasonic absorption is highlighted in the image. Interfacial features of objects with differing densities are delineated in the image as a result of both the displacement introduced by the ultrasound and the inherent sensitivity of x-ray phase contrast imaging to density variations. Experiments with ex vivo murine tumors and human tumor phantoms point out a diagnostic capability of the method for identifying tumors.
- OSTI ID:
- 21352195
- Journal Information:
- Journal of Applied Physics, Vol. 105, Issue 10; Other Information: DOI: 10.1063/1.3111783; (c) 2009 American Institute of Physics; ISSN 0021-8979
- Country of Publication:
- United States
- Language:
- English
Similar Records
Confocal acoustic radiation force optical coherence elastography using a ring ultrasonic transducer
TH-AB-209-07: High Resolution X-Ray-Induced Acoustic Computed Tomography