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Title: Lacrimal Gland Radiosensitivity in Uveal Melanoma Patients

Abstract

Purpose: To find a dose-volume effect for inhomogeneous irradiated lacrimal glands. Methods and Materials: Between 1999 and 2006, 72 patients (42 men and 30 women) were treated with fractionated stereotactic radiotherapy in a prospective, nonrandomized clinical trial (median follow-up, 32 months). A total dose of 50 Gy was given on 5 consecutive days. The mean of all Schirmer test results obtained {>=}6 months after treatment was correlated with the radiation dose delivered to the lacrimal gland. Also, the appearance of dry eye syndrome (DES) was related to the lacrimal gland dose distribution. Results: Of the 72 patients, 17 developed a late Schirmer value <10 mm; 9 patients developed DES. A statistically significant relationship was found between the received median dose in the lacrimal gland vs. reduced tear production (p = 0.000) and vs. the appearance of DES (p = 0.003), respectively. A median dose of 7 Gy/fraction to the lacrimal gland caused a 50% risk of low Schirmer results. A median dose of 10 Gy resulted in a 50% probability of DES. Conclusion: We found a clear dose-volume relationship for irradiated lacrimal glands with regard to reduced tear production and the appearance of DES.

Authors:
 [1];  [2];  [3];  [2];  [3];  [2];  [4]
  1. Department of Radiation-Oncology, Erasmus Medical Center, Rotterdam (Netherlands), E-mail: k.muller@erasmusmc.nl
  2. Department of Radiation-Oncology, Erasmus Medical Center, Rotterdam (Netherlands)
  3. Department of Ophthalmology, Erasmus Medical Center, Rotterdam (Netherlands)
  4. Department of Ophthalmology, Leids University Medical Center, Leiden (Netherlands)
Publication Date:
OSTI Identifier:
21276829
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 74; Journal Issue: 2; Other Information: DOI: 10.1016/j.ijrobp.2008.08.010; PII: S0360-3016(08)03295-1; Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CLINICAL TRIALS; GLANDS; HAZARDS; MELANOMAS; MEN; PATIENTS; RADIATION DOSE DISTRIBUTIONS; RADIATION DOSES; RADIOSENSITIVITY; RADIOTHERAPY; TOXICITY; WOMEN

Citation Formats

Muller, Karin, Nowak, Peter J.C.M., Naus, Nicole, Pan, Connie de, Santen, Cornelis A. van, Levendag, Peter, and Luyten, Gre P.M. Lacrimal Gland Radiosensitivity in Uveal Melanoma Patients. United States: N. p., 2009. Web. doi:10.1016/j.ijrobp.2008.08.010.
Muller, Karin, Nowak, Peter J.C.M., Naus, Nicole, Pan, Connie de, Santen, Cornelis A. van, Levendag, Peter, & Luyten, Gre P.M. Lacrimal Gland Radiosensitivity in Uveal Melanoma Patients. United States. doi:10.1016/j.ijrobp.2008.08.010.
Muller, Karin, Nowak, Peter J.C.M., Naus, Nicole, Pan, Connie de, Santen, Cornelis A. van, Levendag, Peter, and Luyten, Gre P.M. Mon . "Lacrimal Gland Radiosensitivity in Uveal Melanoma Patients". United States. doi:10.1016/j.ijrobp.2008.08.010.
@article{osti_21276829,
title = {Lacrimal Gland Radiosensitivity in Uveal Melanoma Patients},
author = {Muller, Karin and Nowak, Peter J.C.M. and Naus, Nicole and Pan, Connie de and Santen, Cornelis A. van and Levendag, Peter and Luyten, Gre P.M.},
abstractNote = {Purpose: To find a dose-volume effect for inhomogeneous irradiated lacrimal glands. Methods and Materials: Between 1999 and 2006, 72 patients (42 men and 30 women) were treated with fractionated stereotactic radiotherapy in a prospective, nonrandomized clinical trial (median follow-up, 32 months). A total dose of 50 Gy was given on 5 consecutive days. The mean of all Schirmer test results obtained {>=}6 months after treatment was correlated with the radiation dose delivered to the lacrimal gland. Also, the appearance of dry eye syndrome (DES) was related to the lacrimal gland dose distribution. Results: Of the 72 patients, 17 developed a late Schirmer value <10 mm; 9 patients developed DES. A statistically significant relationship was found between the received median dose in the lacrimal gland vs. reduced tear production (p = 0.000) and vs. the appearance of DES (p = 0.003), respectively. A median dose of 7 Gy/fraction to the lacrimal gland caused a 50% risk of low Schirmer results. A median dose of 10 Gy resulted in a 50% probability of DES. Conclusion: We found a clear dose-volume relationship for irradiated lacrimal glands with regard to reduced tear production and the appearance of DES.},
doi = {10.1016/j.ijrobp.2008.08.010},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 2,
volume = 74,
place = {United States},
year = {2009},
month = {6}
}