skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Multi-Institutional External Validation of Seminal Vesicle Invasion Nomograms: Head-to-Head Comparison of Gallina Nomogram Versus 2007 Partin Tables

Abstract

Purpose: The Partin tables represent one of the most widely used prostate cancer staging tools for seminal vesicle invasion (SVI) prediction. Recently, Gallina et al. reported a novel staging tool for the prediction of SVI that further incorporated the use of the percentage of positive biopsy cores. We performed an external validation of the Gallina et al. nomogram and the 2007 Partin tables in a large, multi-institutional North American cohort of men treated with robotic-assisted radical prostatectomy. Methods and Materials: Clinical and pathologic data were prospectively gathered from 2,606 patients treated with robotic-assisted radical prostatectomy at one of four North American robotic referral centers between 2002 and 2007. Discrimination was quantified with the area under the receiver operating characteristics curve. The calibration compared the predicted and observed SVI rates throughout the entire range of predictions. Results: At robotic-assisted radical prostatectomy, SVI was recorded in 4.2% of patients. The discriminant properties of the Gallina et al. nomogram resulted in 81% accuracy compared with 78% for the 2007 Partin tables. The Gallina et al. nomogram overestimated the true rate of SVI. Conversely, the Partin tables underestimated the true rate of SVI. Conclusion: The Gallina et al. nomogram offers greater accuracy (81%) thanmore » the 2007 Partin tables (78%). However, both tools are associated with calibration limitations that need to be acknowledged and considered before their implementation into clinical practice.« less

Authors:
 [1]; ; ; ; ;  [2];  [3];  [4]; ; ; ; ;  [1]; ;  [5];  [6]
  1. Section of Urology, University of Chicago Medical Center, Chicago, IL (United States)
  2. Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, Quebec (Canada)
  3. Department of Urology, University of Pennsylvania, Philadelphia, PA (United States)
  4. (United States)
  5. Department of Urology, Duke University, Durham, NC (United States)
  6. Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, Quebec (Canada), E-mail: pierre.karakiewicz@umontreal.ca
Publication Date:
OSTI Identifier:
21276744
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 73; Journal Issue: 5; Other Information: DOI: 10.1016/j.ijrobp.2008.06.1913; PII: S0360-3016(08)02945-3; Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BIOPSY; CALIBRATION; MEN; NEOPLASMS; NOMOGRAMS; NUCLEAR MEDICINE; PATIENTS; PROSTATE; VALIDATION

Citation Formats

Zorn, Kevin C., Capitanio, Umberto, Jeldres, Claudio, Arjane, Philippe, Perrotte, Paul, Shariat, Shahrokh F., Lee, David I., Urology Associates of North Texas, USMD Hospital in Arlington, Arlington, TX, Shalhav, Arieh L., Zagaja, Gregory P., Shikanov, Sergey A., Gofrit, Ofer N., Thong, Alan E., Albala, David M., Sun, Leon, and Karakiewicz, Pierre I.. Multi-Institutional External Validation of Seminal Vesicle Invasion Nomograms: Head-to-Head Comparison of Gallina Nomogram Versus 2007 Partin Tables. United States: N. p., 2009. Web. doi:10.1016/j.ijrobp.2008.06.1913.
Zorn, Kevin C., Capitanio, Umberto, Jeldres, Claudio, Arjane, Philippe, Perrotte, Paul, Shariat, Shahrokh F., Lee, David I., Urology Associates of North Texas, USMD Hospital in Arlington, Arlington, TX, Shalhav, Arieh L., Zagaja, Gregory P., Shikanov, Sergey A., Gofrit, Ofer N., Thong, Alan E., Albala, David M., Sun, Leon, & Karakiewicz, Pierre I.. Multi-Institutional External Validation of Seminal Vesicle Invasion Nomograms: Head-to-Head Comparison of Gallina Nomogram Versus 2007 Partin Tables. United States. doi:10.1016/j.ijrobp.2008.06.1913.
Zorn, Kevin C., Capitanio, Umberto, Jeldres, Claudio, Arjane, Philippe, Perrotte, Paul, Shariat, Shahrokh F., Lee, David I., Urology Associates of North Texas, USMD Hospital in Arlington, Arlington, TX, Shalhav, Arieh L., Zagaja, Gregory P., Shikanov, Sergey A., Gofrit, Ofer N., Thong, Alan E., Albala, David M., Sun, Leon, and Karakiewicz, Pierre I.. Wed . "Multi-Institutional External Validation of Seminal Vesicle Invasion Nomograms: Head-to-Head Comparison of Gallina Nomogram Versus 2007 Partin Tables". United States. doi:10.1016/j.ijrobp.2008.06.1913.
@article{osti_21276744,
title = {Multi-Institutional External Validation of Seminal Vesicle Invasion Nomograms: Head-to-Head Comparison of Gallina Nomogram Versus 2007 Partin Tables},
author = {Zorn, Kevin C. and Capitanio, Umberto and Jeldres, Claudio and Arjane, Philippe and Perrotte, Paul and Shariat, Shahrokh F. and Lee, David I. and Urology Associates of North Texas, USMD Hospital in Arlington, Arlington, TX and Shalhav, Arieh L. and Zagaja, Gregory P. and Shikanov, Sergey A. and Gofrit, Ofer N. and Thong, Alan E. and Albala, David M. and Sun, Leon and Karakiewicz, Pierre I.},
abstractNote = {Purpose: The Partin tables represent one of the most widely used prostate cancer staging tools for seminal vesicle invasion (SVI) prediction. Recently, Gallina et al. reported a novel staging tool for the prediction of SVI that further incorporated the use of the percentage of positive biopsy cores. We performed an external validation of the Gallina et al. nomogram and the 2007 Partin tables in a large, multi-institutional North American cohort of men treated with robotic-assisted radical prostatectomy. Methods and Materials: Clinical and pathologic data were prospectively gathered from 2,606 patients treated with robotic-assisted radical prostatectomy at one of four North American robotic referral centers between 2002 and 2007. Discrimination was quantified with the area under the receiver operating characteristics curve. The calibration compared the predicted and observed SVI rates throughout the entire range of predictions. Results: At robotic-assisted radical prostatectomy, SVI was recorded in 4.2% of patients. The discriminant properties of the Gallina et al. nomogram resulted in 81% accuracy compared with 78% for the 2007 Partin tables. The Gallina et al. nomogram overestimated the true rate of SVI. Conversely, the Partin tables underestimated the true rate of SVI. Conclusion: The Gallina et al. nomogram offers greater accuracy (81%) than the 2007 Partin tables (78%). However, both tools are associated with calibration limitations that need to be acknowledged and considered before their implementation into clinical practice.},
doi = {10.1016/j.ijrobp.2008.06.1913},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 5,
volume = 73,
place = {United States},
year = {Wed Apr 01 00:00:00 EDT 2009},
month = {Wed Apr 01 00:00:00 EDT 2009}
}