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Title: Delayed liver regeneration after partial hepatectomy in adiponectin knockout mice

Abstract

We previously demonstrated that adiponectin has anti-fibrogenic and anti-inflammatory effects in the liver of mouse models of various liver diseases. However, its role in liver regeneration remains unclear. The aim of this study was to determine the role of adiponectin in liver regeneration. We assessed liver regeneration after partial hepatectomy in wild-type (WT) and adiponectin knockout (KO) mice. We analyzed DNA replication and various signaling pathways involved in cell proliferation and metabolism. Adiponectin KO mice exhibited delayed DNA replication and increased lipid accumulation in the regenerating liver. The expression levels of peroxisome proliferator-activated receptor (PPAR) {alpha} and carnitine palmitoyltransferase-1 (CPT-1), a key enzyme in mitochondrial fatty acid oxidation, were decreased in adiponectin KO mice, suggesting possible contribution of altered fat metabolism to these phenomena. Collectively, the present results highlight a new role for adiponectin in the process of liver regeneration.

Authors:
; ; ; ; ; ; ; ;  [1]; ; ;  [2];  [1];  [1];  [1]
  1. Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, 2-2, K1, Yamadaoka, Suita, Osaka 565-0871 (Japan)
  2. Department of Metabolic Medicine, Osaka University, Graduate School of Medicine, 2-2, B5, Yamadaoka, Suita, Osaka 565-0871 (Japan)
Publication Date:
OSTI Identifier:
21255818
Resource Type:
Journal Article
Journal Name:
Biochemical and Biophysical Research Communications
Additional Journal Information:
Journal Volume: 378; Journal Issue: 1; Other Information: DOI: 10.1016/j.bbrc.2008.10.176; PII: S0006-291X(08)02169-4; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0006-291X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; BIOLOGICAL REGENERATION; CARNITINE; CELL PROLIFERATION; DNA REPLICATION; HEPATECTOMY; INFLAMMATION; LIVER; METABOLISM; MICE; MITOCHONDRIA; OXIDATION; RECEPTORS; REGENERATION

Citation Formats

Ezaki, Hisao, Yoshida, Yuichi, Saji, Yukiko, Takemura, Takayo, Fukushima, Juichi, Matsumoto, Hitoshi, Kamada, Yoshihiro, Wada, Akira, Igura, Takumi, Kihara, Shinji, Funahashi, Tohru, Shimomura, Iichiro, Tamura, Shinji, Kiso, Shinichi, and Hayashi, Norio. Delayed liver regeneration after partial hepatectomy in adiponectin knockout mice. United States: N. p., 2009. Web. doi:10.1016/j.bbrc.2008.10.176.
Ezaki, Hisao, Yoshida, Yuichi, Saji, Yukiko, Takemura, Takayo, Fukushima, Juichi, Matsumoto, Hitoshi, Kamada, Yoshihiro, Wada, Akira, Igura, Takumi, Kihara, Shinji, Funahashi, Tohru, Shimomura, Iichiro, Tamura, Shinji, Kiso, Shinichi, & Hayashi, Norio. Delayed liver regeneration after partial hepatectomy in adiponectin knockout mice. United States. https://doi.org/10.1016/j.bbrc.2008.10.176
Ezaki, Hisao, Yoshida, Yuichi, Saji, Yukiko, Takemura, Takayo, Fukushima, Juichi, Matsumoto, Hitoshi, Kamada, Yoshihiro, Wada, Akira, Igura, Takumi, Kihara, Shinji, Funahashi, Tohru, Shimomura, Iichiro, Tamura, Shinji, Kiso, Shinichi, and Hayashi, Norio. 2009. "Delayed liver regeneration after partial hepatectomy in adiponectin knockout mice". United States. https://doi.org/10.1016/j.bbrc.2008.10.176.
@article{osti_21255818,
title = {Delayed liver regeneration after partial hepatectomy in adiponectin knockout mice},
author = {Ezaki, Hisao and Yoshida, Yuichi and Saji, Yukiko and Takemura, Takayo and Fukushima, Juichi and Matsumoto, Hitoshi and Kamada, Yoshihiro and Wada, Akira and Igura, Takumi and Kihara, Shinji and Funahashi, Tohru and Shimomura, Iichiro and Tamura, Shinji and Kiso, Shinichi and Hayashi, Norio},
abstractNote = {We previously demonstrated that adiponectin has anti-fibrogenic and anti-inflammatory effects in the liver of mouse models of various liver diseases. However, its role in liver regeneration remains unclear. The aim of this study was to determine the role of adiponectin in liver regeneration. We assessed liver regeneration after partial hepatectomy in wild-type (WT) and adiponectin knockout (KO) mice. We analyzed DNA replication and various signaling pathways involved in cell proliferation and metabolism. Adiponectin KO mice exhibited delayed DNA replication and increased lipid accumulation in the regenerating liver. The expression levels of peroxisome proliferator-activated receptor (PPAR) {alpha} and carnitine palmitoyltransferase-1 (CPT-1), a key enzyme in mitochondrial fatty acid oxidation, were decreased in adiponectin KO mice, suggesting possible contribution of altered fat metabolism to these phenomena. Collectively, the present results highlight a new role for adiponectin in the process of liver regeneration.},
doi = {10.1016/j.bbrc.2008.10.176},
url = {https://www.osti.gov/biblio/21255818}, journal = {Biochemical and Biophysical Research Communications},
issn = {0006-291X},
number = 1,
volume = 378,
place = {United States},
year = {Fri Jan 02 00:00:00 EST 2009},
month = {Fri Jan 02 00:00:00 EST 2009}
}