Stereotactic Body Radiotherapy for Primary Lung Cancer at a Dose of 50 Gy Total in Five Fractions to the Periphery of the Planning Target Volume Calculated Using a Superposition Algorithm

Takeda, Atsuya; Sanuki, Naoko; Kunieda, Etsuo; Ohashi, Toshio; Oku, Yohei; Takeda, Toshiaki; Shigematsu, Naoyuki; Kubo, Atsushi

doi:10.1016/j.ijrobp.2008.04.043

Title: Stereotactic Body Radiotherapy for Primary Lung Cancer at a Dose of 50 Gy Total in Five Fractions to the Periphery of the Planning Target Volume Calculated Using a Superposition Algorithm

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Abstract

Purpose: To retrospectively analyze the clinical outcomes of stereotactic body radiotherapy (SBRT) for patients with Stages 1A and 1B non-small-cell lung cancer. Methods and Materials: We reviewed the records of patients with non-small-cell lung cancer treated with curative intent between Dec 2001 and May 2007. All patients had histopathologically or cytologically confirmed disease, increased levels of tumor markers, and/or positive findings on fluorodeoxyglucose positron emission tomography. Staging studies identified their disease as Stage 1A or 1B. Performance status was 2 or less according to World Health Organization guidelines in all cases. The prescribed dose of 50 Gy total in five fractions, calculated by using a superposition algorithm, was defined for the periphery of the planning target volume. Results: One hundred twenty-one patients underwent SBRT during the study period, and 63 were eligible for this analysis. Thirty-eight patients had Stage 1A (T1N0M0) and 25 had Stage 1B (T2N0M0). Forty-nine patients were not appropriate candidates for surgery because of chronic pulmonary disease. Median follow-up of these 49 patients was 31 months (range, 10-72 months). The 3-year local control, disease-free, and overall survival rates in patients with Stages 1A and 1B were 93% and 96% (p = 0.86), 76% and 77% (p =more »« less

Authors:

Takeda, Atsuya ^[1]; Sanuki, Naoko ^[1]; Kunieda, Etsuo ^[2]; Ohashi, Toshio; Oku, Yohei ^[3]; Takeda, Toshiaki ^[2]; Shigematsu, Naoyuki; Kubo, Atsushi ^[3]

Department of Radiology, Ofuna Chuo Hospital, Kamakura (Japan)
Department of Radiology, Tokyo Metropolitan Hiroo General Hospital, Tokyo (Japan)
Department of Radiology, Keio University, Tokyo (Japan)

Publication Date:: Sun Feb 01 00:00:00 EST 2009

OSTI Identifier:: 21172586

Resource Type:: Journal Article

Journal Name:: International Journal of Radiation Oncology, Biology and Physics

Additional Journal Information:: Journal Volume: 73; Journal Issue: 2; Other Information: DOI: 10.1016/j.ijrobp.2008.04.043; PII: S0360-3016(08)00774-8; Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; ALGORITHMS; CARCINOMAS; FLUORODEOXYGLUCOSE; LUNGS; PATIENTS; PLANNING; PNEUMONIA; PNEUMONITIS; POSITRON COMPUTED TOMOGRAPHY; RADIATION DOSES; RADIOTHERAPY; RECOMMENDATIONS; SURGERY; TOXICITY

Citation Formats


                    Takeda, Atsuya, Department of Radiology, Tokyo Metropolitan Hiroo General Hospital, Tokyo, Sanuki, Naoko, Kunieda, Etsuo, Department of Radiology, Keio University, Tokyo, Ohashi, Toshio, Oku, Yohei, Takeda, Toshiaki, Shigematsu, Naoyuki, and Kubo, Atsushi. Stereotactic Body Radiotherapy for Primary Lung Cancer at a Dose of 50 Gy Total in Five Fractions to the Periphery of the Planning Target Volume Calculated Using a Superposition Algorithm.  United States: N. p., 2009. 
        Web.  doi:10.1016/j.ijrobp.2008.04.043.

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                    Takeda, Atsuya, Department of Radiology, Tokyo Metropolitan Hiroo General Hospital, Tokyo, Sanuki, Naoko, Kunieda, Etsuo, Department of Radiology, Keio University, Tokyo, Ohashi, Toshio, Oku, Yohei, Takeda, Toshiaki, Shigematsu, Naoyuki, & Kubo, Atsushi. Stereotactic Body Radiotherapy for Primary Lung Cancer at a Dose of 50 Gy Total in Five Fractions to the Periphery of the Planning Target Volume Calculated Using a Superposition Algorithm.  United States.  https://doi.org/10.1016/j.ijrobp.2008.04.043

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                    Takeda, Atsuya, Department of Radiology, Tokyo Metropolitan Hiroo General Hospital, Tokyo, Sanuki, Naoko, Kunieda, Etsuo, Department of Radiology, Keio University, Tokyo, Ohashi, Toshio, Oku, Yohei, Takeda, Toshiaki, Shigematsu, Naoyuki, and Kubo, Atsushi. 2009.  
        "Stereotactic Body Radiotherapy for Primary Lung Cancer at a Dose of 50 Gy Total in Five Fractions to the Periphery of the Planning Target Volume Calculated Using a Superposition Algorithm".  United States.  https://doi.org/10.1016/j.ijrobp.2008.04.043.

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@article{osti_21172586,

  title        = {Stereotactic Body Radiotherapy for Primary Lung Cancer at a Dose of 50 Gy Total in Five Fractions to the Periphery of the Planning Target Volume Calculated Using a Superposition Algorithm},

  author       = {Takeda, Atsuya and Department of Radiology, Tokyo Metropolitan Hiroo General Hospital, Tokyo and Sanuki, Naoko and Kunieda, Etsuo and Department of Radiology, Keio University, Tokyo and Ohashi, Toshio and Oku, Yohei and Takeda, Toshiaki and Shigematsu, Naoyuki and Kubo, Atsushi},

  abstractNote = {Purpose: To retrospectively analyze the clinical outcomes of stereotactic body radiotherapy (SBRT) for patients with Stages 1A and 1B non-small-cell lung cancer. Methods and Materials: We reviewed the records of patients with non-small-cell lung cancer treated with curative intent between Dec 2001 and May 2007. All patients had histopathologically or cytologically confirmed disease, increased levels of tumor markers, and/or positive findings on fluorodeoxyglucose positron emission tomography. Staging studies identified their disease as Stage 1A or 1B. Performance status was 2 or less according to World Health Organization guidelines in all cases. The prescribed dose of 50 Gy total in five fractions, calculated by using a superposition algorithm, was defined for the periphery of the planning target volume. Results: One hundred twenty-one patients underwent SBRT during the study period, and 63 were eligible for this analysis. Thirty-eight patients had Stage 1A (T1N0M0) and 25 had Stage 1B (T2N0M0). Forty-nine patients were not appropriate candidates for surgery because of chronic pulmonary disease. Median follow-up of these 49 patients was 31 months (range, 10-72 months). The 3-year local control, disease-free, and overall survival rates in patients with Stages 1A and 1B were 93% and 96% (p = 0.86), 76% and 77% (p = 0.83), and 90% and 63% (p = 0.09), respectively. No acute toxicity was observed. Grade 2 or higher radiation pneumonitis was experienced by 3 patients, and 1 of them had fatal bacterial pneumonia. Conclusions: The SBRT at 50 Gy total in five fractions to the periphery of the planning target volume calculated by using a superposition algorithm is feasible. High local control rates were achieved for both T2 and T1 tumors.},

  doi          = {10.1016/j.ijrobp.2008.04.043},

  url          = {https://www.osti.gov/biblio/21172586},
  journal      = {International Journal of Radiation Oncology, Biology and Physics},

  issn         = {0360-3016},

  number       = 2,

  volume       = 73,

  place        = {United States},

  year         = {Sun Feb 01 00:00:00 EST 2009},

  month        = {Sun Feb 01 00:00:00 EST 2009}

}

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