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Title: Radiotherapy for Early-Stage Hodgkin's Lymphoma: A 21st Century Perspective and Review of Multiple Randomized Clinical Trials

Abstract

The treatment of Hodgkin's lymphoma has improved dramatically over the past decades. Over the last half century, Hodgkin's lymphoma has become one of the most curable cancers of adulthood. More than 90% of the patients with localized stages of the disease can be cured with modern treatment strategies. Long-term toxicities are now the major concern for survivors of early-stage disease. Contemporary therapeutic approaches for Hodgkin's lymphoma attempt to preserve the high cure rate achieved, while reducing treatment-related acute and late toxicities. The aim of this review is to re-examine the historical and the current role of radiotherapy for early-stage Hodgkin's lymphoma, given the latest evidence of an increasing role of chemotherapy for the treatment of this malignancy. The literature search was performed in PubMed Plus. Studies on children were excluded.

Authors:
 [1];  [2];  [3]
  1. Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA (United States), E-mail: barad@xrt.upenn.edu
  2. Department of Hematology and School of Public Health, Hadassah-Hebrew University, Jerusalem (Israel)
  3. Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA (United States)
Publication Date:
OSTI Identifier:
21172508
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 72; Journal Issue: 5; Other Information: DOI: 10.1016/j.ijrobp.2008.08.026; PII: S0360-3016(08)03319-1; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CHEMOTHERAPY; CHILDREN; CLINICAL TRIALS; LYMPHOMAS; RADIOTHERAPY; REVIEWS; TOXICITY

Citation Formats

Bar Ad, Voichita, Paltiel, Ora, and Glatstein, Eli. Radiotherapy for Early-Stage Hodgkin's Lymphoma: A 21st Century Perspective and Review of Multiple Randomized Clinical Trials. United States: N. p., 2008. Web. doi:10.1016/j.ijrobp.2008.08.026.
Bar Ad, Voichita, Paltiel, Ora, & Glatstein, Eli. Radiotherapy for Early-Stage Hodgkin's Lymphoma: A 21st Century Perspective and Review of Multiple Randomized Clinical Trials. United States. doi:10.1016/j.ijrobp.2008.08.026.
Bar Ad, Voichita, Paltiel, Ora, and Glatstein, Eli. Mon . "Radiotherapy for Early-Stage Hodgkin's Lymphoma: A 21st Century Perspective and Review of Multiple Randomized Clinical Trials". United States. doi:10.1016/j.ijrobp.2008.08.026.
@article{osti_21172508,
title = {Radiotherapy for Early-Stage Hodgkin's Lymphoma: A 21st Century Perspective and Review of Multiple Randomized Clinical Trials},
author = {Bar Ad, Voichita and Paltiel, Ora and Glatstein, Eli},
abstractNote = {The treatment of Hodgkin's lymphoma has improved dramatically over the past decades. Over the last half century, Hodgkin's lymphoma has become one of the most curable cancers of adulthood. More than 90% of the patients with localized stages of the disease can be cured with modern treatment strategies. Long-term toxicities are now the major concern for survivors of early-stage disease. Contemporary therapeutic approaches for Hodgkin's lymphoma attempt to preserve the high cure rate achieved, while reducing treatment-related acute and late toxicities. The aim of this review is to re-examine the historical and the current role of radiotherapy for early-stage Hodgkin's lymphoma, given the latest evidence of an increasing role of chemotherapy for the treatment of this malignancy. The literature search was performed in PubMed Plus. Studies on children were excluded.},
doi = {10.1016/j.ijrobp.2008.08.026},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 5,
volume = 72,
place = {United States},
year = {2008},
month = {12}
}