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Title: Long-Term Results and Prognostic Factors of Fractionated Strontium-90 Eye Applicator for Pterygium

Abstract

Purpose: To evaluate the long-term safety, effectiveness, and prognostic factors of fractionated postoperative {beta}-irradiation. Methods and Materials: Between 1993 and 2005, 623 patients with 737 pterygium lesions were treated with a strontium-90 eye applicator after surgical excision. The median follow-up period was 60 months (range, 6.7-139.5). Of the 737 lesions, 644 were primary and 93 were recurrences after surgical removal alone. Fractionated radiotherapy (RT) to a total dose of 35 Gy in five to seven fractions was used. Results: A total of 73 local pterygium recurrences (9.9%) were noted. Of the recurrent cases, 80% were noted within 3 years after treatment. The 5- and 10-year probability of local control was 90% and 88%, respectively. The multivariate analysis for all cases demonstrated that gender, age, total radiation dose, recurrent pterygia, and interval between surgery and RT affected the overall local control rate. Late toxicities that might have been associated with strontium-90 RT included scleromalacia (scleral thinning) in nine eyes, adhesion of the eyelids in eight, cataracts in six, and scleral ulcer in five eyes. Conclusion: Fractionated strontium-90 RT to a total dose of approximately 35 Gy in five to seven fractions results in a similar local control rate as higher dosesmore » in other series, with an acceptable complication rate.« less

Authors:
 [1];  [2]; ;  [3]
  1. Department of Radiation Oncology, Marilia Medicine School, Sao Paulo, SP (Brazil), E-mail: gusviani@gmail.com
  2. Department of Radiation Oncology, Marilia Medicine School, Sao Paulo, SP (Brazil)
  3. Department of Ophthalmology, Marilia Medicine School, Sao Paulo, SP (Brazil)
Publication Date:
OSTI Identifier:
21172472
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 72; Journal Issue: 4; Other Information: DOI: 10.1016/j.ijrobp.2008.02.075; PII: S0360-3016(08)00533-6; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CATARACTS; EYES; IRRADIATION; MULTIVARIATE ANALYSIS; PATIENTS; RADIATION DOSES; RADIOTHERAPY; STRONTIUM 90; SURGERY; TOXICITY; ULCERS

Citation Formats

Arruda Viani, Gustavo, Stefano, Eduardo Jose, Fendi, Ligia Issa de, and Carrara Fonseca, Ellen. Long-Term Results and Prognostic Factors of Fractionated Strontium-90 Eye Applicator for Pterygium. United States: N. p., 2008. Web. doi:10.1016/j.ijrobp.2008.02.075.
Arruda Viani, Gustavo, Stefano, Eduardo Jose, Fendi, Ligia Issa de, & Carrara Fonseca, Ellen. Long-Term Results and Prognostic Factors of Fractionated Strontium-90 Eye Applicator for Pterygium. United States. doi:10.1016/j.ijrobp.2008.02.075.
Arruda Viani, Gustavo, Stefano, Eduardo Jose, Fendi, Ligia Issa de, and Carrara Fonseca, Ellen. Sat . "Long-Term Results and Prognostic Factors of Fractionated Strontium-90 Eye Applicator for Pterygium". United States. doi:10.1016/j.ijrobp.2008.02.075.
@article{osti_21172472,
title = {Long-Term Results and Prognostic Factors of Fractionated Strontium-90 Eye Applicator for Pterygium},
author = {Arruda Viani, Gustavo and Stefano, Eduardo Jose and Fendi, Ligia Issa de and Carrara Fonseca, Ellen},
abstractNote = {Purpose: To evaluate the long-term safety, effectiveness, and prognostic factors of fractionated postoperative {beta}-irradiation. Methods and Materials: Between 1993 and 2005, 623 patients with 737 pterygium lesions were treated with a strontium-90 eye applicator after surgical excision. The median follow-up period was 60 months (range, 6.7-139.5). Of the 737 lesions, 644 were primary and 93 were recurrences after surgical removal alone. Fractionated radiotherapy (RT) to a total dose of 35 Gy in five to seven fractions was used. Results: A total of 73 local pterygium recurrences (9.9%) were noted. Of the recurrent cases, 80% were noted within 3 years after treatment. The 5- and 10-year probability of local control was 90% and 88%, respectively. The multivariate analysis for all cases demonstrated that gender, age, total radiation dose, recurrent pterygia, and interval between surgery and RT affected the overall local control rate. Late toxicities that might have been associated with strontium-90 RT included scleromalacia (scleral thinning) in nine eyes, adhesion of the eyelids in eight, cataracts in six, and scleral ulcer in five eyes. Conclusion: Fractionated strontium-90 RT to a total dose of approximately 35 Gy in five to seven fractions results in a similar local control rate as higher doses in other series, with an acceptable complication rate.},
doi = {10.1016/j.ijrobp.2008.02.075},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 4,
volume = 72,
place = {United States},
year = {2008},
month = {11}
}