Tumor Location, Interval Between Surgery and Radiotherapy, and Boost Technique Influence Local Control After Breast-Conserving Surgery and Radiation: Retrospective Analysis of Monoinstitutional Long-Term Results

Knauerhase, Hellen; Strietzel, Manfred; Gerber, Bernd; Reimer, Toralf; Fietkau, Rainer

doi:10.1016/j.ijrobp.2008.02.007

Title: Tumor Location, Interval Between Surgery and Radiotherapy, and Boost Technique Influence Local Control After Breast-Conserving Surgery and Radiation: Retrospective Analysis of Monoinstitutional Long-Term Results

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Abstract

Purpose: To obtain long-term data on local tumor control after treatment of invasive breast cancer by breast-conserving surgery and adjuvant radiotherapy (RT), in consideration of the interstitial high-dose-rate boost technique. Patients and Methods: A total of 263 women with 268 mammary carcinomas (International Union Against Cancer Stage I-IIB) who had undergone breast-conserving surgery and adjuvant RT between 1990 and 1994 were included. The potential risk factors for local recurrence-free survival were investigated. Results: During a median follow-up period of 94 months, 27 locoregional recurrences, 25 of which were in breast, were diagnosed. The cumulative rate of in-breast recurrence was 4.1% {+-} 1.4% at 5 years of follow-up and 9.9% {+-} 2.4% at 10 years. The multivariate analysis identified medial tumor location and delayed RT (defined as an interval of >2 months between surgery and the start of RT) as significant risk factors for in-breast recurrence in the overall study population. Medial tumor location vs. lateral/central location (hazard ratio, 2.48; 95% confidence interval, 1.06-5.84) resulted in a cumulative in-breast recurrence rate of 22.5% {+-} 8.3% vs. 6.9% {+-} 2.3% at 10 years. Delayed RT (hazard ratio, 2.84; 95% confidence interval, 1.13-7.13) resulted in a cumulative in-breast recurrence rate of 18.5% {+-}more »« less

Authors:

Knauerhase, Hellen; Strietzel, Manfred ^[1]; Gerber, Bernd; Reimer, Toralf ^[2]; Fietkau, Rainer ^[1]

Department of Radiation Therapy, University of Rostock, Rostock (Germany)
Department of Gynecology and Obstetrics, University of Rostock, Suedstadt Hospital, Rostock (Germany)

Publication Date:: Sat Nov 15 00:00:00 EST 2008

OSTI Identifier:: 21172455

Resource Type:: Journal Article

Journal Name:: International Journal of Radiation Oncology, Biology and Physics

Additional Journal Information:: Journal Volume: 72; Journal Issue: 4; Other Information: DOI: 10.1016/j.ijrobp.2008.02.007; PII: S0360-3016(08)00280-0; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; CARCINOMAS; DOSE RATES; MAMMARY GLANDS; PATIENTS; RADIATION HAZARDS; RADIOTHERAPY; SURGERY

Citation Formats


                    Knauerhase, Hellen, Strietzel, Manfred, Gerber, Bernd, Reimer, Toralf, Fietkau, Rainer, and Department of Radiation Therapy, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen. Tumor Location, Interval Between Surgery and Radiotherapy, and Boost Technique Influence Local Control After Breast-Conserving Surgery and Radiation: Retrospective Analysis of Monoinstitutional Long-Term Results.  United States: N. p., 2008. 
        Web.  doi:10.1016/j.ijrobp.2008.02.007.

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                    Knauerhase, Hellen, Strietzel, Manfred, Gerber, Bernd, Reimer, Toralf, Fietkau, Rainer, & Department of Radiation Therapy, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen. Tumor Location, Interval Between Surgery and Radiotherapy, and Boost Technique Influence Local Control After Breast-Conserving Surgery and Radiation: Retrospective Analysis of Monoinstitutional Long-Term Results.  United States.  https://doi.org/10.1016/j.ijrobp.2008.02.007

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                    Knauerhase, Hellen, Strietzel, Manfred, Gerber, Bernd, Reimer, Toralf, Fietkau, Rainer, and Department of Radiation Therapy, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen. 2008.  
        "Tumor Location, Interval Between Surgery and Radiotherapy, and Boost Technique Influence Local Control After Breast-Conserving Surgery and Radiation: Retrospective Analysis of Monoinstitutional Long-Term Results".  United States.  https://doi.org/10.1016/j.ijrobp.2008.02.007.

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@article{osti_21172455,

  title        = {Tumor Location, Interval Between Surgery and Radiotherapy, and Boost Technique Influence Local Control After Breast-Conserving Surgery and Radiation: Retrospective Analysis of Monoinstitutional Long-Term Results},

  author       = {Knauerhase, Hellen and Strietzel, Manfred and Gerber, Bernd and Reimer, Toralf and Fietkau, Rainer and Department of Radiation Therapy, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen},

  abstractNote = {Purpose: To obtain long-term data on local tumor control after treatment of invasive breast cancer by breast-conserving surgery and adjuvant radiotherapy (RT), in consideration of the interstitial high-dose-rate boost technique. Patients and Methods: A total of 263 women with 268 mammary carcinomas (International Union Against Cancer Stage I-IIB) who had undergone breast-conserving surgery and adjuvant RT between 1990 and 1994 were included. The potential risk factors for local recurrence-free survival were investigated. Results: During a median follow-up period of 94 months, 27 locoregional recurrences, 25 of which were in breast, were diagnosed. The cumulative rate of in-breast recurrence was 4.1% {+-} 1.4% at 5 years of follow-up and 9.9% {+-} 2.4% at 10 years. The multivariate analysis identified medial tumor location and delayed RT (defined as an interval of >2 months between surgery and the start of RT) as significant risk factors for in-breast recurrence in the overall study population. Medial tumor location vs. lateral/central location (hazard ratio, 2.48; 95% confidence interval, 1.06-5.84) resulted in a cumulative in-breast recurrence rate of 22.5% {+-} 8.3% vs. 6.9% {+-} 2.3% at 10 years. Delayed RT (hazard ratio, 2.84; 95% confidence interval, 1.13-7.13) resulted in a cumulative in-breast recurrence rate of 18.5% {+-} 6.2% vs. 6.8% {+-} 2.4% at 10 years. The multivariate analysis also showed that the risk of in-breast recurrence was lower after high-dose-rate boost therapy than after external beam boost therapy in patients with laterally/centrally located tumors (hazard ratio, 3.25; 95% confidence interval, 0.91-11.65). Conclusion: Tumor location, interval between surgery and RT, and boost technique might influence local control of breast cancer treated by breast-conserving surgery and RT.},

  doi          = {10.1016/j.ijrobp.2008.02.007},

  url          = {https://www.osti.gov/biblio/21172455},
  journal      = {International Journal of Radiation Oncology, Biology and Physics},

  issn         = {0360-3016},

  number       = 4,

  volume       = 72,

  place        = {United States},

  year         = {Sat Nov 15 00:00:00 EST 2008},

  month        = {Sat Nov 15 00:00:00 EST 2008}

}

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