Bile acid regulates c-Jun expression through the orphan nuclear receptor SHP induction in gastric cells
- Bongseng Memorial Hospital, Dong Gu, Busan 601-723 (Korea, Republic of)
- Department of Molecular Biology, Pusan National University, Jang-Jeong Dong, Keum-Jeong Gu, Busan 609-735 (Korea, Republic of)
- Department of Biochemistry, College of Oriental Medicine, Dongeui University, Busan 614-052 (Korea, Republic of)
Bile reflux is considered to be one of the most important causative factors in gastric carcinogenesis, due to the attendant inflammatory changes in the gastric mucosa. In this study, we have assessed the molecular mechanisms inherent to the contribution of bile acid to the transcriptional regulation of inflammatory-related genes. In this study, we demonstrated that bile acid induced the expression of the SHP orphan nuclear receptor at the transcriptional level via c-Jun activation. Bile acid also enhanced the protein interaction of NF-{kappa}B and SHP, thereby resulting in an increase in c-Jun expression and the production of the inflammatory cytokine, TNF{alpha}. These results indicate that bile acid performs a critical function in the regulation of the induction of inflammatory-related genes in gastric cells, and that bile acid-mediated gene expression provides a pre-clue for the development of gastric cellular malformation.
- OSTI ID:
- 21143646
- Journal Information:
- Biochemical and Biophysical Research Communications, Vol. 369, Issue 2; Other Information: DOI: 10.1016/j.bbrc.2008.02.065; PII: S0006-291X(08)00294-5; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
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