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Title: Descriptive Study of Patients Receiving Excision and Radiotherapy for Keloids

Abstract

Purpose: To review and describe our institution's outcomes in patients treated with external beam radiotherapy after keloid excision. Methods and Materials: This was a retrospective study. Patients who received radiotherapy between July 1994 and January 2004 after keloid excision were identified. A questionnaire was mailed regarding sociodemographic factors, early and late radiation toxicities, the need for additional therapy, and satisfaction level. All patients had received a total of 15 Gy in three daily 5-Gy fractions. Treatment started within 24 h after surgery and was delivered on a Siemens orthovoltage machine. The data were analyzed using the STATA statistical package. Results: A total of 234 patients were approached. The response rate was 41%, and 75% were female. The mean age was 36.5 years (range, 16-69 years). The patients were mainly of European (53.1%) or African (19.8%) descent. For early toxicity outcomes, 54.2% reported skin redness and 24% reported skin peeling. For late toxicity outcomes, 27% reported telangiectasia and 62% reported permanent skin color changes. No association was found with gender, skin color, or age for the late toxicity outcomes. Of the patients responding, 14.6% required adjuvant treatment. On a visual scale of 1-10 for the satisfaction level, 60% reported a satisfactionmore » level of {>=}8. Telangiectasia was the most significant predictor of a low satisfaction level ({<=}3, p < 0.005). Conclusion: The results of our study have shown that orthovoltage-based radiotherapy after surgical excision for keloids is a good method for the prevention of relapse. It is well tolerated, causes little toxicity, and leads to a high patient satisfaction level.« less

Authors:
 [1]; ;  [2]
  1. Department of Medical Oncology, Jewish General Hospital, McGill University, Montreal, QC (Canada), E-mail: giovanna.speranza@mail.mcgill.ca
  2. Department of Radiation Oncology, Jewish General Hospital, McGill University, Montreal, QC (Canada)
Publication Date:
OSTI Identifier:
21124403
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 71; Journal Issue: 5; Other Information: DOI: 10.1016/j.ijrobp.2007.12.015; PII: S0360-3016(07)04707-4; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; PATIENTS; RADIOTHERAPY; REVIEWS; SKIN; SURGERY; TOXICITY

Citation Formats

Speranza, Giovanna, Sultanem, Khalil M.D., and Muanza, Thierry. Descriptive Study of Patients Receiving Excision and Radiotherapy for Keloids. United States: N. p., 2008. Web. doi:10.1016/j.ijrobp.2007.12.015.
Speranza, Giovanna, Sultanem, Khalil M.D., & Muanza, Thierry. Descriptive Study of Patients Receiving Excision and Radiotherapy for Keloids. United States. doi:10.1016/j.ijrobp.2007.12.015.
Speranza, Giovanna, Sultanem, Khalil M.D., and Muanza, Thierry. Fri . "Descriptive Study of Patients Receiving Excision and Radiotherapy for Keloids". United States. doi:10.1016/j.ijrobp.2007.12.015.
@article{osti_21124403,
title = {Descriptive Study of Patients Receiving Excision and Radiotherapy for Keloids},
author = {Speranza, Giovanna and Sultanem, Khalil M.D. and Muanza, Thierry},
abstractNote = {Purpose: To review and describe our institution's outcomes in patients treated with external beam radiotherapy after keloid excision. Methods and Materials: This was a retrospective study. Patients who received radiotherapy between July 1994 and January 2004 after keloid excision were identified. A questionnaire was mailed regarding sociodemographic factors, early and late radiation toxicities, the need for additional therapy, and satisfaction level. All patients had received a total of 15 Gy in three daily 5-Gy fractions. Treatment started within 24 h after surgery and was delivered on a Siemens orthovoltage machine. The data were analyzed using the STATA statistical package. Results: A total of 234 patients were approached. The response rate was 41%, and 75% were female. The mean age was 36.5 years (range, 16-69 years). The patients were mainly of European (53.1%) or African (19.8%) descent. For early toxicity outcomes, 54.2% reported skin redness and 24% reported skin peeling. For late toxicity outcomes, 27% reported telangiectasia and 62% reported permanent skin color changes. No association was found with gender, skin color, or age for the late toxicity outcomes. Of the patients responding, 14.6% required adjuvant treatment. On a visual scale of 1-10 for the satisfaction level, 60% reported a satisfaction level of {>=}8. Telangiectasia was the most significant predictor of a low satisfaction level ({<=}3, p < 0.005). Conclusion: The results of our study have shown that orthovoltage-based radiotherapy after surgical excision for keloids is a good method for the prevention of relapse. It is well tolerated, causes little toxicity, and leads to a high patient satisfaction level.},
doi = {10.1016/j.ijrobp.2007.12.015},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 5,
volume = 71,
place = {United States},
year = {2008},
month = {8}
}