Magnitude of Residual Internal Anatomy Motion on Heavy Charged Particle Dose Distribution in Respiratory Gated Lung Therapy
- Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba (Japan)
- Accelerator Engineering Corporation, Chiba (Japan)
- Hospital, National Institute of Radiological Sciences, Chiba (Japan)
- Department of Planning and Management, National Institute of Radiological Sciences, Chiba, Japan, Chiba (Japan)
Purpose: To assess the variation in carbon beam dose distribution due to residual motion in lung cancer patients undergoing respiratory-gated radiotherapy. Methods and Materials: A total of 11 lung cancer patients underwent four-dimensional computed tomography with a 256-multislice computed tomography scanner under free-breathing conditions. A compensating bolus was designed to cover the treatment beam for all planning target volumes during a 30% duty cycle centered on exhalation (gating window). This bolus was applied to the four-dimensional computed tomography data for one respiratory cycle, and then the carbon beam dose distribution was calculated. Results: A water equivalent pathlength variation of <5 mm was observed in the gating window, but this increased to {<=}20 mm on inhalation. As a result, beam overshoot/undershoot occurred around inhalation, which increased the excessive dosing to normal tissues and the organs at risk. The dose for >95% volume irradiation is dependent on the respiratory phase but not the gating window. However, the dose for >95% volume irradiation correlated well with the tumor displacement distance. More than 90% of the dose for >95% volume irradiation could be delivered in the gating window with <4-mm tumor displacement resulting from exhalation. Conclusion: The results of our study have shown that even when the treatment beam delivery occurs outside the gating window, the prescribed dose to the target is not affected in patients with a tumor displacement of <4 mm. Thus, respiratory gating is not required in radiotherapy for patients with <4-mm tumor displacement in a respiratory cycle.
- OSTI ID:
- 21124293
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics, Vol. 71, Issue 2; Other Information: DOI: 10.1016/j.ijrobp.2008.02.024; PII: S0360-3016(08)00326-X; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0360-3016
- Country of Publication:
- United States
- Language:
- English
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