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Title: Variation in lung cancer risk by smoky coal subtype in Xuanwei, China

Abstract

Lung cancer rates in Xuanwei County have been among the highest in China for both males and females and have been causally associated with exposure to indoor smoky (bituminous) coal emissions that contain very high levels of polycyclic aromatic hydrocarbons. There are numerous coal mines across the County. Although lung cancer risk is strongly associated with the use of smoky coal as a whole, variation in risk by smoky coal subtype has not been characterized as yet. We conducted a population-based case-control study of 498 lung cancer cases and 498 controls, individually matched to case subjects on age and sex to examine risk by coal subtype. Odds ratios (ORs) and 95% confidence intervals (CIs) for coal subtype were calculated by conditional logistic regression, adjusting for potential confounders. Overall, smoky coal use was positively and statistically significantly associated with lung cancer risk, when compared with the use of smokeless coal or wood (OR = 7.7, 95% CI = 4.5-13.3). Furthermore, there was a marked heterogeneity in risk estimates for specific subtypes of smoky coal (test for heterogeneity: p = 5.17 x 10{sup -10}). Estimates were highest for coal of the Laibin (OR = 24.8, 95 % CI = 12.4-49.6) and Longtanmore » (OR = 11.6, 95 % CI = 5.0-27.2) coal types and lower for coal from other subtypes. These findings strongly suggest that in Xuanwei and elsewhere, the carcinogenic potential of coal combustion products can exhibit substantial local variation by specific coal source.« less

Authors:
; ; ; ; ; ; ; ; ; ; ; ;  [1]
  1. NCI, Bethesda, MD (United States). Occupational & Environmental Epidemiology Branch
Publication Date:
OSTI Identifier:
21116242
Resource Type:
Journal Article
Journal Name:
International Journal of Cancer
Additional Journal Information:
Journal Volume: 123; Journal Issue: 9; Journal ID: ISSN 0020-7136
Country of Publication:
United States
Language:
English
Subject:
01 COAL, LIGNITE, AND PEAT; RISK ASSESSMENT; LUNGS; NEOPLASMS; BITUMINOUS COAL; CHINA; INDOOR AIR POLLUTION; EMISSION; FOOD PROCESSING; HEALTH HAZARDS; CARCINOMAS

Citation Formats

Lan, Q, He, X Z, Shen, M, Tian, L W, Liu, L Z, Lai, H, Chen, W, Berndt, S I, Hosgood, H D, Lee, K M, Zheng, T Z, Blair, A, and Chapman, R S. Variation in lung cancer risk by smoky coal subtype in Xuanwei, China. United States: N. p., 2008. Web. doi:10.1002/ijc.23748.
Lan, Q, He, X Z, Shen, M, Tian, L W, Liu, L Z, Lai, H, Chen, W, Berndt, S I, Hosgood, H D, Lee, K M, Zheng, T Z, Blair, A, & Chapman, R S. Variation in lung cancer risk by smoky coal subtype in Xuanwei, China. United States. https://doi.org/10.1002/ijc.23748
Lan, Q, He, X Z, Shen, M, Tian, L W, Liu, L Z, Lai, H, Chen, W, Berndt, S I, Hosgood, H D, Lee, K M, Zheng, T Z, Blair, A, and Chapman, R S. Sat . "Variation in lung cancer risk by smoky coal subtype in Xuanwei, China". United States. https://doi.org/10.1002/ijc.23748.
@article{osti_21116242,
title = {Variation in lung cancer risk by smoky coal subtype in Xuanwei, China},
author = {Lan, Q and He, X Z and Shen, M and Tian, L W and Liu, L Z and Lai, H and Chen, W and Berndt, S I and Hosgood, H D and Lee, K M and Zheng, T Z and Blair, A and Chapman, R S},
abstractNote = {Lung cancer rates in Xuanwei County have been among the highest in China for both males and females and have been causally associated with exposure to indoor smoky (bituminous) coal emissions that contain very high levels of polycyclic aromatic hydrocarbons. There are numerous coal mines across the County. Although lung cancer risk is strongly associated with the use of smoky coal as a whole, variation in risk by smoky coal subtype has not been characterized as yet. We conducted a population-based case-control study of 498 lung cancer cases and 498 controls, individually matched to case subjects on age and sex to examine risk by coal subtype. Odds ratios (ORs) and 95% confidence intervals (CIs) for coal subtype were calculated by conditional logistic regression, adjusting for potential confounders. Overall, smoky coal use was positively and statistically significantly associated with lung cancer risk, when compared with the use of smokeless coal or wood (OR = 7.7, 95% CI = 4.5-13.3). Furthermore, there was a marked heterogeneity in risk estimates for specific subtypes of smoky coal (test for heterogeneity: p = 5.17 x 10{sup -10}). Estimates were highest for coal of the Laibin (OR = 24.8, 95 % CI = 12.4-49.6) and Longtan (OR = 11.6, 95 % CI = 5.0-27.2) coal types and lower for coal from other subtypes. These findings strongly suggest that in Xuanwei and elsewhere, the carcinogenic potential of coal combustion products can exhibit substantial local variation by specific coal source.},
doi = {10.1002/ijc.23748},
url = {https://www.osti.gov/biblio/21116242}, journal = {International Journal of Cancer},
issn = {0020-7136},
number = 9,
volume = 123,
place = {United States},
year = {2008},
month = {11}
}