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Title: Percutaneous Transcatheter One-Step Mechanical Aortic Disc Valve Prosthesis Implantation: A Preliminary Feasibility Study in Swine

Abstract

Purpose. To evaluate the feasibility of one-step implantation of a new type of stent-based mechanical aortic disc valve prosthesis (MADVP) above and across the native aortic valve and its short-term function in swine with both functional and dysfunctional native valves. Methods. The MADVP consisted of a folding disc valve made of silicone elastomer attached to either a nitinol Z-stent (Z model) or a nitinol cross-braided stent (SX model). Implantation of 10 MADVPs (6 Z and 4 SX models) was attempted in 10 swine: 4 (2 Z and 2 SX models) with a functional native valve and 6 (4 Z and 2 SX models) with aortic regurgitation induced either by intentional valve injury or by MADVP placement across the native valve. MADVP function was observed for up to 3 hr after implantation. Results. MADVP implantation was successful in 9 swine. One animal died of induced massive regurgitation prior to implantation. Four MADVPs implanted above functioning native valves exhibited good function. In 5 swine with regurgitation, MADVP implantation corrected the induced native valve dysfunction and the device's continuous good function was observed in 4 animals. One MADVP (SX model) placed across native valve gradually migrated into the left ventricle. Conclusion. The testedmore » MADVP can be implanted above and across the native valve in a one-step procedure and can replace the function of the regurgitating native valve. Further technical development and testing are warranted, preferably with a manufactured MADVP.« less

Authors:
 [1]; ;  [2]; ; ;  [3]
  1. Institute for Clinical and Experimental Medicine, Intensive Care Unit, Clinic of Cardiology (Czech Republic), E-mail: jan.sochman@medicon.cz
  2. Institute for Clinical and Experimental Medicine, Department of Diagnostic and Interventional Radiology (Czech Republic)
  3. Oregon Health and Sciences University, Dotter Interventional Institute (United States)
Publication Date:
OSTI Identifier:
21091276
Resource Type:
Journal Article
Resource Relation:
Journal Name: Cardiovascular and Interventional Radiology; Journal Volume: 29; Journal Issue: 1; Other Information: DOI: 10.1007/s00270-005-0029-9; Copyright (c) 2006 Springer Science+Business Media, Inc.; www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; FEASIBILITY STUDIES; INJURIES; NICKEL ALLOYS; SILICONES; SWINE; TITANIUM ALLOYS; VALVES

Citation Formats

Sochman, Jan, Peregrin, Jan H., Rocek, Miloslav, Timmermans, Hans A., Pavcnik, Dusan, and Roesch, Josef. Percutaneous Transcatheter One-Step Mechanical Aortic Disc Valve Prosthesis Implantation: A Preliminary Feasibility Study in Swine. United States: N. p., 2006. Web. doi:10.1007/S00270-005-0029-9.
Sochman, Jan, Peregrin, Jan H., Rocek, Miloslav, Timmermans, Hans A., Pavcnik, Dusan, & Roesch, Josef. Percutaneous Transcatheter One-Step Mechanical Aortic Disc Valve Prosthesis Implantation: A Preliminary Feasibility Study in Swine. United States. doi:10.1007/S00270-005-0029-9.
Sochman, Jan, Peregrin, Jan H., Rocek, Miloslav, Timmermans, Hans A., Pavcnik, Dusan, and Roesch, Josef. Wed . "Percutaneous Transcatheter One-Step Mechanical Aortic Disc Valve Prosthesis Implantation: A Preliminary Feasibility Study in Swine". United States. doi:10.1007/S00270-005-0029-9.
@article{osti_21091276,
title = {Percutaneous Transcatheter One-Step Mechanical Aortic Disc Valve Prosthesis Implantation: A Preliminary Feasibility Study in Swine},
author = {Sochman, Jan and Peregrin, Jan H. and Rocek, Miloslav and Timmermans, Hans A. and Pavcnik, Dusan and Roesch, Josef},
abstractNote = {Purpose. To evaluate the feasibility of one-step implantation of a new type of stent-based mechanical aortic disc valve prosthesis (MADVP) above and across the native aortic valve and its short-term function in swine with both functional and dysfunctional native valves. Methods. The MADVP consisted of a folding disc valve made of silicone elastomer attached to either a nitinol Z-stent (Z model) or a nitinol cross-braided stent (SX model). Implantation of 10 MADVPs (6 Z and 4 SX models) was attempted in 10 swine: 4 (2 Z and 2 SX models) with a functional native valve and 6 (4 Z and 2 SX models) with aortic regurgitation induced either by intentional valve injury or by MADVP placement across the native valve. MADVP function was observed for up to 3 hr after implantation. Results. MADVP implantation was successful in 9 swine. One animal died of induced massive regurgitation prior to implantation. Four MADVPs implanted above functioning native valves exhibited good function. In 5 swine with regurgitation, MADVP implantation corrected the induced native valve dysfunction and the device's continuous good function was observed in 4 animals. One MADVP (SX model) placed across native valve gradually migrated into the left ventricle. Conclusion. The tested MADVP can be implanted above and across the native valve in a one-step procedure and can replace the function of the regurgitating native valve. Further technical development and testing are warranted, preferably with a manufactured MADVP.},
doi = {10.1007/S00270-005-0029-9},
journal = {Cardiovascular and Interventional Radiology},
number = 1,
volume = 29,
place = {United States},
year = {Wed Feb 15 00:00:00 EST 2006},
month = {Wed Feb 15 00:00:00 EST 2006}
}