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Title: Volume Changes of Experimental Carotid Sidewall Aneurysms Due to Embolization with Liquid Embolic Agents: A Multidetector CT Angiography Study

Abstract

Iodine-containing polyvinyl alcohol polymer (I-PVAL) is a novel precipitating liquid embolic that allows for artifact-free evaluation of CT angiography (CTA). As accurate aneurysm volumetry can be performed with multidetector CTA, we determined volumes of experimental aneurysms before, immediately after, and 4 weeks after embolization of 14 porcine experimental carotid sidewall aneurysms with this liquid embolic. An automated three-dimensional software measurement tool was used for volumetric analysis of volume-rendering CTA data. Furthermore, intra-aneurysmal pressure changes during liquid embolization were measured in four silicone aneurysms and potential polymer volume changes within 4 weeks were assessed in vitro. Liquid embolic injection was performed during temporary balloon occlusion of the aneurysm neck, resulting in a mean occlusion rate of 98.3%. Aneurysms enlarged significantly during embolization by 61.1 {+-} 28.9%, whereas a significant shrinkage of 5.6 {+-} 2.7% was observed within the follow-up period. Histologic analysis revealed an inflammatory foreign body reaction with partial polymer degradation. In silicone aneurysm models, intra-aneurysmal pressure remained unchanged during liquid embolic injection, whereas balloon inflation resulted in a mean pressure increase of 31.2 {+-} 0.7%. No polymer shrinkage was observed in vitro. The aneurysm enlargement noted was presumably due to pressure elevation after balloon inflation, which resulted in dilatationmore » of the weak venous wall of the newly constructed aneurysm-another shortcoming of this experimental aneurysm model. The volume decrease after 4 weeks expressed partial polymer degradation.« less

Authors:
 [1];  [2];  [3]; ;  [4];  [5];  [6];  [3];  [4]
  1. Charite, Campus Virchow Clinic, Department of Radiology (Germany), E-mail: oliver.dudeck@charite.de
  2. Charite, Campus Virchow Clinic, Department of Neuropathology (Germany)
  3. University of Geneva, School of Pharmacy (Switzerland)
  4. Charite, Campus Virchow Clinic, Department of Radiology (Germany)
  5. Albert-Ludwigs-University of Freiburg, Department of Cardiovascular Surgery (Germany)
  6. University Hospital of Geneva, Neuroradiology Section (Switzerland)
Publication Date:
OSTI Identifier:
21091101
Resource Type:
Journal Article
Resource Relation:
Journal Name: Cardiovascular and Interventional Radiology; Journal Volume: 29; Journal Issue: 6; Other Information: DOI: 10.1007/s00270-005-2361-5; Copyright (c) 2006 Springer Science+Business Media, Inc.; www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BIOMEDICAL RADIOGRAPHY; BLOOD VESSELS; COMPUTERIZED TOMOGRAPHY; IN VITRO; INFLAMMATION; INJECTION; IODINE; PVA; SILICONES; VOLUMETRIC ANALYSIS

Citation Formats

Dudeck, O., Okuducu, A. F., Jordan, O., Tesmer, K., Pech, M., Weigang, E., Ruefenacht, D. A., Doelker, E., and Felix, R. Volume Changes of Experimental Carotid Sidewall Aneurysms Due to Embolization with Liquid Embolic Agents: A Multidetector CT Angiography Study. United States: N. p., 2006. Web. doi:10.1007/S00270-005-2361-5.
Dudeck, O., Okuducu, A. F., Jordan, O., Tesmer, K., Pech, M., Weigang, E., Ruefenacht, D. A., Doelker, E., & Felix, R. Volume Changes of Experimental Carotid Sidewall Aneurysms Due to Embolization with Liquid Embolic Agents: A Multidetector CT Angiography Study. United States. doi:10.1007/S00270-005-2361-5.
Dudeck, O., Okuducu, A. F., Jordan, O., Tesmer, K., Pech, M., Weigang, E., Ruefenacht, D. A., Doelker, E., and Felix, R. Fri . "Volume Changes of Experimental Carotid Sidewall Aneurysms Due to Embolization with Liquid Embolic Agents: A Multidetector CT Angiography Study". United States. doi:10.1007/S00270-005-2361-5.
@article{osti_21091101,
title = {Volume Changes of Experimental Carotid Sidewall Aneurysms Due to Embolization with Liquid Embolic Agents: A Multidetector CT Angiography Study},
author = {Dudeck, O. and Okuducu, A. F. and Jordan, O. and Tesmer, K. and Pech, M. and Weigang, E. and Ruefenacht, D. A. and Doelker, E. and Felix, R.},
abstractNote = {Iodine-containing polyvinyl alcohol polymer (I-PVAL) is a novel precipitating liquid embolic that allows for artifact-free evaluation of CT angiography (CTA). As accurate aneurysm volumetry can be performed with multidetector CTA, we determined volumes of experimental aneurysms before, immediately after, and 4 weeks after embolization of 14 porcine experimental carotid sidewall aneurysms with this liquid embolic. An automated three-dimensional software measurement tool was used for volumetric analysis of volume-rendering CTA data. Furthermore, intra-aneurysmal pressure changes during liquid embolization were measured in four silicone aneurysms and potential polymer volume changes within 4 weeks were assessed in vitro. Liquid embolic injection was performed during temporary balloon occlusion of the aneurysm neck, resulting in a mean occlusion rate of 98.3%. Aneurysms enlarged significantly during embolization by 61.1 {+-} 28.9%, whereas a significant shrinkage of 5.6 {+-} 2.7% was observed within the follow-up period. Histologic analysis revealed an inflammatory foreign body reaction with partial polymer degradation. In silicone aneurysm models, intra-aneurysmal pressure remained unchanged during liquid embolic injection, whereas balloon inflation resulted in a mean pressure increase of 31.2 {+-} 0.7%. No polymer shrinkage was observed in vitro. The aneurysm enlargement noted was presumably due to pressure elevation after balloon inflation, which resulted in dilatation of the weak venous wall of the newly constructed aneurysm-another shortcoming of this experimental aneurysm model. The volume decrease after 4 weeks expressed partial polymer degradation.},
doi = {10.1007/S00270-005-2361-5},
journal = {Cardiovascular and Interventional Radiology},
number = 6,
volume = 29,
place = {United States},
year = {Fri Dec 15 00:00:00 EST 2006},
month = {Fri Dec 15 00:00:00 EST 2006}
}
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