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Title: Magnetic Resonance Imaging of Acute Reperfused Myocardial Infarction: Intraindividual Comparison of ECIII-60 and Gd-DTPA in a Swine Model

Abstract

Purpose. To compare a necrosis-avid contrast agent (NACA) bis-Gd-DTPA-pamoic acid derivative (ECIII-60) after intracoronary delivery with an extracellular agent Gd-DTPA after intravenous injection on magnetic resonance imaging (MRI) in a swine model of acute reperfused myocardial infarction (MI). Methods. Eight pigs underwent 90 min of transcatheter coronary balloon occlusion and 60 min of reperfusion. After intravenous injection of Gd-DTPA at a dose of 0.2 mmol/kg, all pigs were scanned with T1-weighted MRI until the delayed enhancement of MI disappeared. Then they were intracoronarily infused with ECIII-60 at 0.0025 mmol/kg and imaged for 5 hr. Signal intensity, infarct-over-normal contrast ratio and relative infarct size were quantified, compared, and correlated with the results of postmortem MRI and triphenyltetrazolium chloride (TTC) histochemical staining. Results. A contrast ratio over 3.0 was induced by both Gd-DTPA and ECIII-60. However, while the delayed enhancement with Gd-DTPA virtually vanished in 1 hr, ECIII-60 at an 80x smaller dose depicted the MI accurately over 5 hr as proven by ex vivo MRI and TTC staining. Conclusion. Both Gd-DTPA and ECIII-60 strongly enhanced acute MI. Comparing with fading contrast in a narrow time window with intravenous Gd-DTPA, intracoronary ECIII-60 persistently demarcated the acute MI, indicating a potential method formore » postprocedural assessment of myocardial viability after coronary interventions.« less

Authors:
;  [1]; ;  [2];  [1];  [2];  [3];  [1];  [2]; ;  [1]; ;  [4]
  1. Zhongda Hospital of Southeast University, Department of Radiology (China)
  2. Zhongda Hospital of Southeast University, Department of Cardiology (China)
  3. Zhongda Hospital of Southeast University, Department of Anaesthesiology (China)
  4. University Hospitals, University of Leuven, Department of Radiology (Belgium), E-mail: yicheng.ni@med.kuleuven.ac.be
Publication Date:
OSTI Identifier:
21091008
Resource Type:
Journal Article
Resource Relation:
Journal Name: Cardiovascular and Interventional Radiology; Journal Volume: 30; Journal Issue: 2; Other Information: DOI: 10.1007/s00270-006-0004-0; Copyright (c) 2007 Springer Science+Business Media, Inc.; www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CHLORIDES; CONTRAST MEDIA; CORONARIES; GADOLINIUM COMPOUNDS; INTRAVENOUS INJECTION; MYOCARDIAL INFARCTION; NECROSIS; NMR IMAGING; SWINE

Citation Formats

Jin Jiyang, Teng Gaojun, Feng Yi, Wu Yanping, Jin Qindi, Wang Yu, Wang Zhen, Lu Qin, Jiang Yibo, Wang Shengqi, Chen Feng, Marchal, Guy, and Ni Yicheng. Magnetic Resonance Imaging of Acute Reperfused Myocardial Infarction: Intraindividual Comparison of ECIII-60 and Gd-DTPA in a Swine Model. United States: N. p., 2007. Web. doi:10.1007/S00270-006-0004-0.
Jin Jiyang, Teng Gaojun, Feng Yi, Wu Yanping, Jin Qindi, Wang Yu, Wang Zhen, Lu Qin, Jiang Yibo, Wang Shengqi, Chen Feng, Marchal, Guy, & Ni Yicheng. Magnetic Resonance Imaging of Acute Reperfused Myocardial Infarction: Intraindividual Comparison of ECIII-60 and Gd-DTPA in a Swine Model. United States. doi:10.1007/S00270-006-0004-0.
Jin Jiyang, Teng Gaojun, Feng Yi, Wu Yanping, Jin Qindi, Wang Yu, Wang Zhen, Lu Qin, Jiang Yibo, Wang Shengqi, Chen Feng, Marchal, Guy, and Ni Yicheng. Sun . "Magnetic Resonance Imaging of Acute Reperfused Myocardial Infarction: Intraindividual Comparison of ECIII-60 and Gd-DTPA in a Swine Model". United States. doi:10.1007/S00270-006-0004-0.
@article{osti_21091008,
title = {Magnetic Resonance Imaging of Acute Reperfused Myocardial Infarction: Intraindividual Comparison of ECIII-60 and Gd-DTPA in a Swine Model},
author = {Jin Jiyang and Teng Gaojun and Feng Yi and Wu Yanping and Jin Qindi and Wang Yu and Wang Zhen and Lu Qin and Jiang Yibo and Wang Shengqi and Chen Feng and Marchal, Guy and Ni Yicheng},
abstractNote = {Purpose. To compare a necrosis-avid contrast agent (NACA) bis-Gd-DTPA-pamoic acid derivative (ECIII-60) after intracoronary delivery with an extracellular agent Gd-DTPA after intravenous injection on magnetic resonance imaging (MRI) in a swine model of acute reperfused myocardial infarction (MI). Methods. Eight pigs underwent 90 min of transcatheter coronary balloon occlusion and 60 min of reperfusion. After intravenous injection of Gd-DTPA at a dose of 0.2 mmol/kg, all pigs were scanned with T1-weighted MRI until the delayed enhancement of MI disappeared. Then they were intracoronarily infused with ECIII-60 at 0.0025 mmol/kg and imaged for 5 hr. Signal intensity, infarct-over-normal contrast ratio and relative infarct size were quantified, compared, and correlated with the results of postmortem MRI and triphenyltetrazolium chloride (TTC) histochemical staining. Results. A contrast ratio over 3.0 was induced by both Gd-DTPA and ECIII-60. However, while the delayed enhancement with Gd-DTPA virtually vanished in 1 hr, ECIII-60 at an 80x smaller dose depicted the MI accurately over 5 hr as proven by ex vivo MRI and TTC staining. Conclusion. Both Gd-DTPA and ECIII-60 strongly enhanced acute MI. Comparing with fading contrast in a narrow time window with intravenous Gd-DTPA, intracoronary ECIII-60 persistently demarcated the acute MI, indicating a potential method for postprocedural assessment of myocardial viability after coronary interventions.},
doi = {10.1007/S00270-006-0004-0},
journal = {Cardiovascular and Interventional Radiology},
number = 2,
volume = 30,
place = {United States},
year = {Sun Apr 15 00:00:00 EDT 2007},
month = {Sun Apr 15 00:00:00 EDT 2007}
}