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Title: Conformation of ceramide 6 molecules and chain-flip transitions in the lipid matrix of the outermost layer of mammalian skin, the stratum corneum

Abstract

Neutron diffraction from oriented multilamellar model stratum corneum (SC) membranes provides information on the internal nanostructure and hydration of the lipid bilayer. The main distinguishing feature of model SC membranes based on ceramide 6 is the extremely small intermembrane space (1 A). The role of the fully extended (FE) conformation of ceramide 6 molecules in the organization of the nanostructure of the lipid matrix is discussed. The FE conformation gives rise to extremely strong intermembrane attractions (armature reinforcement), which tighten the adjacent bilayers to form steric contacts. Chain-flip transitions in the conformation of ceramide molecules account for structural alterations in native and model SC membranes upon their hydration.

Authors:
 [1]
  1. Joint Institute for Nuclear Research (Russian Federation), E-mail: kiselev@jinr.ru
Publication Date:
OSTI Identifier:
21090902
Resource Type:
Journal Article
Resource Relation:
Journal Name: Crystallography Reports; Journal Volume: 52; Journal Issue: 3; Other Information: DOI: 10.1134/S1063774507030340; Copyright (c) 2007 Nauka/Interperiodica; Article Copyright (c) 2007 Pleiades Publishing, Inc; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; HYDRATION; LAYERS; LIPIDS; MEMBRANES; NANOSTRUCTURES; NEUTRON DIFFRACTION; SKIN

Citation Formats

Kiselev, M. A.. Conformation of ceramide 6 molecules and chain-flip transitions in the lipid matrix of the outermost layer of mammalian skin, the stratum corneum. United States: N. p., 2007. Web. doi:10.1134/S1063774507030340.
Kiselev, M. A.. Conformation of ceramide 6 molecules and chain-flip transitions in the lipid matrix of the outermost layer of mammalian skin, the stratum corneum. United States. doi:10.1134/S1063774507030340.
Kiselev, M. A.. Tue . "Conformation of ceramide 6 molecules and chain-flip transitions in the lipid matrix of the outermost layer of mammalian skin, the stratum corneum". United States. doi:10.1134/S1063774507030340.
@article{osti_21090902,
title = {Conformation of ceramide 6 molecules and chain-flip transitions in the lipid matrix of the outermost layer of mammalian skin, the stratum corneum},
author = {Kiselev, M. A.},
abstractNote = {Neutron diffraction from oriented multilamellar model stratum corneum (SC) membranes provides information on the internal nanostructure and hydration of the lipid bilayer. The main distinguishing feature of model SC membranes based on ceramide 6 is the extremely small intermembrane space (1 A). The role of the fully extended (FE) conformation of ceramide 6 molecules in the organization of the nanostructure of the lipid matrix is discussed. The FE conformation gives rise to extremely strong intermembrane attractions (armature reinforcement), which tighten the adjacent bilayers to form steric contacts. Chain-flip transitions in the conformation of ceramide molecules account for structural alterations in native and model SC membranes upon their hydration.},
doi = {10.1134/S1063774507030340},
journal = {Crystallography Reports},
number = 3,
volume = 52,
place = {United States},
year = {Tue May 15 00:00:00 EDT 2007},
month = {Tue May 15 00:00:00 EDT 2007}
}