Systemic Pulsatile Pressure in Type II Endoleaks After Stent Grafting of Experimental Abdominal Aortic Aneurysms
Abstract
Purpose: To investigate pressure and maximum rate of rise of systolic pressure (peak dP/dt) in completely excluded aneurysms and endoleaks to determine the hemodynamic impact of endoleaks. Methods: In mongrel dogs (n =36) experimental aneurysms were created by insertion of a patch (portion of rectus abdomen is muscle sheath) into the infrarenalaorta. In group I (n 18), all aortic branches of the aneurysm were ligated and all aneurysms were completely excluded by stent grafts. Group II (n = 18) consisted of aneurysms with patent aortic side branches that represented sources of endoleaks.One week (n = 12), six weeks (n = 12),and six months (n = 12) after stent grafting,hemodynamic measurements were obtained in thrombosed aneurysms and proved endoleaks. Systemic blood pressure and intraaneurysmal pressure were simultaneously measured and the respective peak dP/dt were computed. Results: At the six-month follow-up, the systolic-pressure ratio (intraaneurysmatic pressure: systemic pressure)was significantly increased in endoleaks compared to non-perfused areas(0.879 {+-} 0.042 versus 0.438 {+-} 0.176, p <0.01, group II) or completely excluded aneurysms (0.385 {+-}0.221, group I). Peak dP/dt ratio (intraaneurysmal peak dP/dt: systemic peak dP/dt) was 0.922 {+-} 0.154 in endoleaks, compared to 0.084 {+-} 0.080 in non-perfused areas (group II, p <0.01), andmore »
- Authors:
-
- University Hospital, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Department of Radiology (Germany)
- UniversityHospital of Mannheim, Mannheim, Department of Radiology (Germany)
- University Hospital, Johannes Gutenberg University ofMainz, Mainz, Department of Cardiothoracic and VascularSurgery (Germany)
- Publication Date:
- OSTI Identifier:
- 21088389
- Resource Type:
- Journal Article
- Journal Name:
- Cardiovascular and Interventional Radiology
- Additional Journal Information:
- Journal Volume: 26; Journal Issue: 3; Other Information: DOI: 10.1007/s00270-003-2689-7; Copyright (c) 2003 Springer-Verlag New York, Inc.; www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0174-1551
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; BLOOD PRESSURE; DOGS; GRAFTS; MUSCLES; PATENTS; VASCULAR DISEASES
Citation Formats
Pitton, Michael Bernhard, E-mail: pitton@radiologie.klinik.uni-mainz.de, Schmenger, Patrick, Dueber, Christoph, Neufang, Achim, and Thelen, Manfred. Systemic Pulsatile Pressure in Type II Endoleaks After Stent Grafting of Experimental Abdominal Aortic Aneurysms. United States: N. p., 2003.
Web. doi:10.1007/S00270-003-2689-7.
Pitton, Michael Bernhard, E-mail: pitton@radiologie.klinik.uni-mainz.de, Schmenger, Patrick, Dueber, Christoph, Neufang, Achim, & Thelen, Manfred. Systemic Pulsatile Pressure in Type II Endoleaks After Stent Grafting of Experimental Abdominal Aortic Aneurysms. United States. https://doi.org/10.1007/S00270-003-2689-7
Pitton, Michael Bernhard, E-mail: pitton@radiologie.klinik.uni-mainz.de, Schmenger, Patrick, Dueber, Christoph, Neufang, Achim, and Thelen, Manfred. 2003.
"Systemic Pulsatile Pressure in Type II Endoleaks After Stent Grafting of Experimental Abdominal Aortic Aneurysms". United States. https://doi.org/10.1007/S00270-003-2689-7.
@article{osti_21088389,
title = {Systemic Pulsatile Pressure in Type II Endoleaks After Stent Grafting of Experimental Abdominal Aortic Aneurysms},
author = {Pitton, Michael Bernhard, E-mail: pitton@radiologie.klinik.uni-mainz.de and Schmenger, Patrick and Dueber, Christoph and Neufang, Achim and Thelen, Manfred},
abstractNote = {Purpose: To investigate pressure and maximum rate of rise of systolic pressure (peak dP/dt) in completely excluded aneurysms and endoleaks to determine the hemodynamic impact of endoleaks. Methods: In mongrel dogs (n =36) experimental aneurysms were created by insertion of a patch (portion of rectus abdomen is muscle sheath) into the infrarenalaorta. In group I (n 18), all aortic branches of the aneurysm were ligated and all aneurysms were completely excluded by stent grafts. Group II (n = 18) consisted of aneurysms with patent aortic side branches that represented sources of endoleaks.One week (n = 12), six weeks (n = 12),and six months (n = 12) after stent grafting,hemodynamic measurements were obtained in thrombosed aneurysms and proved endoleaks. Systemic blood pressure and intraaneurysmal pressure were simultaneously measured and the respective peak dP/dt were computed. Results: At the six-month follow-up, the systolic-pressure ratio (intraaneurysmatic pressure: systemic pressure)was significantly increased in endoleaks compared to non-perfused areas(0.879 {+-} 0.042 versus 0.438 {+-} 0.176, p <0.01, group II) or completely excluded aneurysms (0.385 {+-}0.221, group I). Peak dP/dt ratio (intraaneurysmal peak dP/dt: systemic peak dP/dt) was 0.922 {+-} 0.154 in endoleaks, compared to 0.084 {+-} 0.080 in non-perfused areas (group II, p <0.01), and was 0.146 {+-} 0.121 in completely excluded aneurysms (group I). The diastolic-pressure ratio was also increased inendoleaks compared to non-perfused areas (0.929 {+-} 0.088 versus 0.655 {+-} 0.231, p < 0.01, group II) or completely excluded aneurysms (0.641 {+-} 0.278, group I). In excluded aneurysms, pressure exposure declined as the length of the follow-up period increased. Conclusion: Type II endoleaks transmit pulsatile pressure of near systemic level and indicate insufficient treatment result. In contrast, complete endovascular exclusion of aneurysms results in significantly reduced pressure exposure.},
doi = {10.1007/S00270-003-2689-7},
url = {https://www.osti.gov/biblio/21088389},
journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 3,
volume = 26,
place = {United States},
year = {Sun Jun 15 00:00:00 EDT 2003},
month = {Sun Jun 15 00:00:00 EDT 2003}
}