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Title: Diagnosis of Hepatocellular Carcinoma Complicating Liver Cirrhosis: Utility of Repeat Ultrasound-Guided Biopsy after Unsuccessful First Sampling

Abstract

Purpose: To evaluate the utility of a second ultrasound-guided fine-needle biopsy of liver nodules thought to be hepatocellular carcinoma when the original biopsy has failed to provide a reliable diagnosis. Methods: Thirty-seven cirrhotic patients underwent ultrasound-guided fine-needle biopsy of liver nodules that were subsequently diagnosed as hepatocellular carcinoma. Each biopsy involved a single puncture with a 20 G cutting needle, which yielded pathologic material used both for cytologic and histologic studies. In 23 cases (mean diameter of nodules 48 mm) the biopsy furnished exclusively necrotic material (non-diagnostic subgroup); in the other 14 cases (mean diameter 26 mm) the biopsy yielded no neoplastic elements (false-negative subgroup). All 37 nodules were subjected to repeat biopsies performed in the same manner. Results: The repeat biopsies provided a diagnosis of hepatocellular carcinoma in six of the 23 patients from the non-diagnostic subgroup and in seven of the 14 in the false-negative subgroup. Overall, repeat biopsy produced a diagnostic gain of 35.1%. Conclusion: The chance of success with repeat biopsy of hepatocellular carcinoma is limited and may depend to some extent on the characteristics of the lesions (i.e., areas of necrosis in large nodules, well-differentiated cellular populations in small ones)

Authors:
 [1];  [2];  [3]; ;  [1]; ;  [4]
  1. Unita Operativa diGastroenterologia, Ospedale 'Casa Sollievo della Sofferenza' IRCCS, viale Cappuccini, I-71013 San Giovanni Rotondo, Foggia (Italy)
  2. Dipartimento diMedicina Interna e Scienze Biomediche, Universita degli Studi, I-43100 Parma (Italy)
  3. Dipartimento di Radiologia e Diagnostica perImmagini, Universita degli Studi, I-60100 Ancona (Italy)
  4. Servizio di Anatomiae Istologia Patologica, Ospedale 'Casa Sollievo della Sofferenza' IRCCS, I-71013 San Giovanni Rotondo, Foggia (Italy)
Publication Date:
OSTI Identifier:
21083428
Resource Type:
Journal Article
Journal Name:
Cardiovascular and Interventional Radiology
Additional Journal Information:
Journal Volume: 25; Journal Issue: 4; Other Information: DOI: 10.1007/s00270-001-0123-6; Copyright (c) 2002 Springer-Verlag New York, Inc; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0174-1551
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BIOPSY; DIAGNOSIS; HEPATOMAS; LIVER; LIVER CIRRHOSIS; PATIENTS; SAMPLING

Citation Formats

Caturelli, Eugenio, Biasini, Elisabetta, Bartolucci, Francesca, Facciorusso, Domenico, Decembrino, Francesco, Attino, Vito, and Bisceglia, Michele. Diagnosis of Hepatocellular Carcinoma Complicating Liver Cirrhosis: Utility of Repeat Ultrasound-Guided Biopsy after Unsuccessful First Sampling. United States: N. p., 2002. Web. doi:10.1007/S00270-001-0123-6.
Caturelli, Eugenio, Biasini, Elisabetta, Bartolucci, Francesca, Facciorusso, Domenico, Decembrino, Francesco, Attino, Vito, & Bisceglia, Michele. Diagnosis of Hepatocellular Carcinoma Complicating Liver Cirrhosis: Utility of Repeat Ultrasound-Guided Biopsy after Unsuccessful First Sampling. United States. doi:10.1007/S00270-001-0123-6.
Caturelli, Eugenio, Biasini, Elisabetta, Bartolucci, Francesca, Facciorusso, Domenico, Decembrino, Francesco, Attino, Vito, and Bisceglia, Michele. Thu . "Diagnosis of Hepatocellular Carcinoma Complicating Liver Cirrhosis: Utility of Repeat Ultrasound-Guided Biopsy after Unsuccessful First Sampling". United States. doi:10.1007/S00270-001-0123-6.
@article{osti_21083428,
title = {Diagnosis of Hepatocellular Carcinoma Complicating Liver Cirrhosis: Utility of Repeat Ultrasound-Guided Biopsy after Unsuccessful First Sampling},
author = {Caturelli, Eugenio and Biasini, Elisabetta and Bartolucci, Francesca and Facciorusso, Domenico and Decembrino, Francesco and Attino, Vito and Bisceglia, Michele},
abstractNote = {Purpose: To evaluate the utility of a second ultrasound-guided fine-needle biopsy of liver nodules thought to be hepatocellular carcinoma when the original biopsy has failed to provide a reliable diagnosis. Methods: Thirty-seven cirrhotic patients underwent ultrasound-guided fine-needle biopsy of liver nodules that were subsequently diagnosed as hepatocellular carcinoma. Each biopsy involved a single puncture with a 20 G cutting needle, which yielded pathologic material used both for cytologic and histologic studies. In 23 cases (mean diameter of nodules 48 mm) the biopsy furnished exclusively necrotic material (non-diagnostic subgroup); in the other 14 cases (mean diameter 26 mm) the biopsy yielded no neoplastic elements (false-negative subgroup). All 37 nodules were subjected to repeat biopsies performed in the same manner. Results: The repeat biopsies provided a diagnosis of hepatocellular carcinoma in six of the 23 patients from the non-diagnostic subgroup and in seven of the 14 in the false-negative subgroup. Overall, repeat biopsy produced a diagnostic gain of 35.1%. Conclusion: The chance of success with repeat biopsy of hepatocellular carcinoma is limited and may depend to some extent on the characteristics of the lesions (i.e., areas of necrosis in large nodules, well-differentiated cellular populations in small ones)},
doi = {10.1007/S00270-001-0123-6},
journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 4,
volume = 25,
place = {United States},
year = {2002},
month = {8}
}