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Title: Complications Following Balloon-Occluded Arterial Infusion Chemotherapy for Pelvic Malignancies

Abstract

Purpose: To evaluate the incidence and causes of complications associated with balloon-occluded arterial infusion chemotherapy (BOAI) for pelvic malignancies. Methods: In 34 courses of BOAI in 22 patients with pelvic malignancies, we analyzed the incidence of complications as well as the effect of the dose of the anticancer drugs, the infusion site, and the number of BOAI administrations on these complications. Complications were divided into two categories: cystitis-like symptoms and neurological complications such as pain, numbness, and paresthesia of the lower extremities and the hip. Results: Eleven patients (50%) suffered from complications, seven (31.8%) from neurological complications and four (18.2%) from cystitis-like symptoms. The complications appeared in 14 courses (42.4%) of BOAI, neurological complications in 10 (30.3%) and cystitis-like symptoms in four (12.1%). A high dose of anti-cancer drugs and infusion from the anterior division tended to induce neurological complications more frequently; however, the cystitis-like symptoms were not related to any factors. Conclusion: Our results indicate that a smaller dose of anti-cancer drugs should be infused from the bilateral internal iliac arteries for safer pelvic BOAI.

Authors:
 [1];  [2]; ;  [1];  [3];  [4]
  1. Department of Radiology, Nishi-Kobe Medical Center, 5-7-1 Koji-dai, Nishi-ku, Kobe 651-2273 (Japan)
  2. Central Radiological Division, Kobe University, School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017 (Japan)
  3. Department of Urology, Nishi-Kobe Medical Center, 5-7-1 Koji-dai, Nishi-ku, Kobe 651-2273 (Japan)
  4. Department of Gynecology and Obstetrics, Nishi-Kobe Medical Center, 5-7-1 Koji-dai, Nishi-ku, Kobe 651-2273 (Japan)
Publication Date:
OSTI Identifier:
21080265
Resource Type:
Journal Article
Journal Name:
Cardiovascular and Interventional Radiology
Additional Journal Information:
Journal Volume: 22; Journal Issue: 6; Other Information: DOI: 10.1007/s002709900436; Copyright (c) 1999 Springer-Verlag New York Inc; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0174-1551
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ANTINEOPLASTIC DRUGS; ARTERIES; CHEMOTHERAPY; COMPUTERIZED TOMOGRAPHY; INFUSION; NEOPLASMS; PAIN

Citation Formats

Sugimoto, Koji, Hirota, Shozo, Imanaka, Kazufumi, Kawabe, Tetsuya, Nakayama, Yoshiharu, and Takeuchi, Yasuhito. Complications Following Balloon-Occluded Arterial Infusion Chemotherapy for Pelvic Malignancies. United States: N. p., 1999. Web. doi:10.1007/S002709900436.
Sugimoto, Koji, Hirota, Shozo, Imanaka, Kazufumi, Kawabe, Tetsuya, Nakayama, Yoshiharu, & Takeuchi, Yasuhito. Complications Following Balloon-Occluded Arterial Infusion Chemotherapy for Pelvic Malignancies. United States. doi:10.1007/S002709900436.
Sugimoto, Koji, Hirota, Shozo, Imanaka, Kazufumi, Kawabe, Tetsuya, Nakayama, Yoshiharu, and Takeuchi, Yasuhito. Mon . "Complications Following Balloon-Occluded Arterial Infusion Chemotherapy for Pelvic Malignancies". United States. doi:10.1007/S002709900436.
@article{osti_21080265,
title = {Complications Following Balloon-Occluded Arterial Infusion Chemotherapy for Pelvic Malignancies},
author = {Sugimoto, Koji and Hirota, Shozo and Imanaka, Kazufumi and Kawabe, Tetsuya and Nakayama, Yoshiharu and Takeuchi, Yasuhito},
abstractNote = {Purpose: To evaluate the incidence and causes of complications associated with balloon-occluded arterial infusion chemotherapy (BOAI) for pelvic malignancies. Methods: In 34 courses of BOAI in 22 patients with pelvic malignancies, we analyzed the incidence of complications as well as the effect of the dose of the anticancer drugs, the infusion site, and the number of BOAI administrations on these complications. Complications were divided into two categories: cystitis-like symptoms and neurological complications such as pain, numbness, and paresthesia of the lower extremities and the hip. Results: Eleven patients (50%) suffered from complications, seven (31.8%) from neurological complications and four (18.2%) from cystitis-like symptoms. The complications appeared in 14 courses (42.4%) of BOAI, neurological complications in 10 (30.3%) and cystitis-like symptoms in four (12.1%). A high dose of anti-cancer drugs and infusion from the anterior division tended to induce neurological complications more frequently; however, the cystitis-like symptoms were not related to any factors. Conclusion: Our results indicate that a smaller dose of anti-cancer drugs should be infused from the bilateral internal iliac arteries for safer pelvic BOAI.},
doi = {10.1007/S002709900436},
journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 6,
volume = 22,
place = {United States},
year = {1999},
month = {11}
}