skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Skin: Major target organ of allergic reactions to small molecular weight compounds

Abstract

Skin is a major target organ for allergic reactions to small molecular weight compounds. Drug allergic reactions may be life-threatening such as in the case of anaphylactic reactions or bullous drug reactions and occur in about 5% of all hospitalized patients. Allergic contact dermatitis has an enormous influence on the social life of the patient because it is the most frequent reason for occupational skin diseases and the treatment and prevention of this disease cost approximately Euro 3 billion per year in Germany. The different proposed pathophysiological pathways leading to a drug eruption are discussed in this paper. All major enzymes which are involved in the metabolism of xenobiotica were shown to be present in skin. Evidence supporting the role of metabolism in the development of drug allergy and allergic contact dermatitis is demonstrated in the example of sulphonamides and fragrances.

Authors:
 [1]; ; ;  [2];  [3]
  1. Department of Dermatology and Allergology, Univ.-Hospital, RWTH Aachen, Pauwelsstr. 30, D-52074 Aachen (Germany), E-mail: hans.merk@post.rwth-aachen.de
  2. Department of Dermatology and Allergology, Univ.-Hospital, RWTH Aachen, Pauwelsstr. 30, D-52074 Aachen (Germany)
  3. Dermatochemistry and Skin Allergy, Department of Chemistry, Goeteborg University, SE-412 96 Goeteborg (Sweden)
Publication Date:
OSTI Identifier:
21077842
Resource Type:
Journal Article
Resource Relation:
Journal Name: Toxicology and Applied Pharmacology; Journal Volume: 224; Journal Issue: 3; Other Information: DOI: 10.1016/j.taap.2007.01.004; PII: S0041-008X(07)00020-8; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ALLERGY; COST; DERMATITIS; DRUGS; ENZYMES; METABOLISM; MOLECULAR WEIGHT; PATIENTS; SKIN

Citation Formats

Merk, Hans F., Baron, Jens M., Neis, Mark M., Obrigkeit, Daniela Hoeller, and Karlberg, Ann-Therese. Skin: Major target organ of allergic reactions to small molecular weight compounds. United States: N. p., 2007. Web. doi:10.1016/j.taap.2007.01.004.
Merk, Hans F., Baron, Jens M., Neis, Mark M., Obrigkeit, Daniela Hoeller, & Karlberg, Ann-Therese. Skin: Major target organ of allergic reactions to small molecular weight compounds. United States. doi:10.1016/j.taap.2007.01.004.
Merk, Hans F., Baron, Jens M., Neis, Mark M., Obrigkeit, Daniela Hoeller, and Karlberg, Ann-Therese. Thu . "Skin: Major target organ of allergic reactions to small molecular weight compounds". United States. doi:10.1016/j.taap.2007.01.004.
@article{osti_21077842,
title = {Skin: Major target organ of allergic reactions to small molecular weight compounds},
author = {Merk, Hans F. and Baron, Jens M. and Neis, Mark M. and Obrigkeit, Daniela Hoeller and Karlberg, Ann-Therese},
abstractNote = {Skin is a major target organ for allergic reactions to small molecular weight compounds. Drug allergic reactions may be life-threatening such as in the case of anaphylactic reactions or bullous drug reactions and occur in about 5% of all hospitalized patients. Allergic contact dermatitis has an enormous influence on the social life of the patient because it is the most frequent reason for occupational skin diseases and the treatment and prevention of this disease cost approximately Euro 3 billion per year in Germany. The different proposed pathophysiological pathways leading to a drug eruption are discussed in this paper. All major enzymes which are involved in the metabolism of xenobiotica were shown to be present in skin. Evidence supporting the role of metabolism in the development of drug allergy and allergic contact dermatitis is demonstrated in the example of sulphonamides and fragrances.},
doi = {10.1016/j.taap.2007.01.004},
journal = {Toxicology and Applied Pharmacology},
number = 3,
volume = 224,
place = {United States},
year = {Thu Nov 01 00:00:00 EDT 2007},
month = {Thu Nov 01 00:00:00 EDT 2007}
}