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Title: Multiple Image Radiography With Diffraction Enhanced Imaging For Breast Specimen

Abstract

Biological samples are of great interest for many imaging techniques. The samples usually contain small structures and weak absorption properties. The combinations of weak signals with overlying structures make feature recognition difficult in many cases. In the x-ray regime, a relatively new imaging technique Diffraction Enhanced Imaging (DEI) has superior tissue contrast over conventional radiography and is proven to be very sensitive method. Multiple images taken by DEI are called Multiple Image Radiography (MIR). The purpose of this study is to validate the potential application of the method and to show that MIR-DEI method may give more information about the sample.

Authors:
 [1];  [2];  [3];  [4]
  1. Harran University, Department of Physics, Sanliurfa, 63300 (Turkey)
  2. National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY 1197 (United States)
  3. Department of Physics and Medical Physics, University of Qatar, Doha (Qatar)
  4. Department of Anatomy and Cell Biology, College of Medicine, A315 Life Sciences Building, 107 Wiggins Road, Saskatoon, SK, S7N 5E5 (Canada)
Publication Date:
OSTI Identifier:
21057179
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 899; Journal Issue: 1; Conference: 6. international conference of the Balkan Physical Union, Istanbul (Turkey), 22-26 Aug 2006; Other Information: DOI: 10.1063/1.2733231; (c) 2007 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ABSORPTION; BIOMEDICAL RADIOGRAPHY; IMAGE PROCESSING; IMAGES; MAMMARY GLANDS; REFRACTION; X RADIATION; X-RAY DIFFRACTION

Citation Formats

Oltulu, Oral, Zhong Zhong, Hasnah, Moumen, and Chapman, Dean. Multiple Image Radiography With Diffraction Enhanced Imaging For Breast Specimen. United States: N. p., 2007. Web. doi:10.1063/1.2733231.
Oltulu, Oral, Zhong Zhong, Hasnah, Moumen, & Chapman, Dean. Multiple Image Radiography With Diffraction Enhanced Imaging For Breast Specimen. United States. doi:10.1063/1.2733231.
Oltulu, Oral, Zhong Zhong, Hasnah, Moumen, and Chapman, Dean. Mon . "Multiple Image Radiography With Diffraction Enhanced Imaging For Breast Specimen". United States. doi:10.1063/1.2733231.
@article{osti_21057179,
title = {Multiple Image Radiography With Diffraction Enhanced Imaging For Breast Specimen},
author = {Oltulu, Oral and Zhong Zhong and Hasnah, Moumen and Chapman, Dean},
abstractNote = {Biological samples are of great interest for many imaging techniques. The samples usually contain small structures and weak absorption properties. The combinations of weak signals with overlying structures make feature recognition difficult in many cases. In the x-ray regime, a relatively new imaging technique Diffraction Enhanced Imaging (DEI) has superior tissue contrast over conventional radiography and is proven to be very sensitive method. Multiple images taken by DEI are called Multiple Image Radiography (MIR). The purpose of this study is to validate the potential application of the method and to show that MIR-DEI method may give more information about the sample.},
doi = {10.1063/1.2733231},
journal = {AIP Conference Proceedings},
number = 1,
volume = 899,
place = {United States},
year = {Mon Apr 23 00:00:00 EDT 2007},
month = {Mon Apr 23 00:00:00 EDT 2007}
}
  • Diffraction-enhanced imaging (DEI) is an analyzer-based x-ray imaging method that produces separate images depicting the projected x-ray absorption and refractive properties of an object. Because the imaging model of DEI does not account for ultra-small-angle x-ray scattering (USAXS), the images produced in DEI can contain artefacts and inaccuracies in medical imaging applications. In this work, we investigate an extended DEI method for concurrent reconstruction of three images that depict an object's projected x-ray absorption, refraction and USAXS properties. The extended DEI method can be viewed as an implementation of the recently proposed multiple-image radiography paradigm. Validation studies are conducted bymore » use of computer-simulated and synchrotron measurement data.« less
  • No abstract prepared.
  • No abstract prepared.
  • The purpose of this study is to evaluate the performance of an antiscatter grid and its potential benefit on image quality for a full-field digital mammography (FFDM) detector geometry at energies typical for temporal subtraction contrast-enhanced (CE) breast imaging. The signal intensities from primary, scatter, and glare were quantified in images acquired with an a-Si/CsI(Tl) FFDM detector using a Rh target and a 0.27 mm Cu filter at tube voltages ranging from 35 to 49 kV. Measurements were obtained at the center of the irradiation region of 20-80 mm thick breast-equivalent phantoms. The phantoms were imaged with and without anmore » antiscatter grid. Based on these data, the performance of the antiscatter grid was determined by calculating the primary and scatter transmission factors (T{sub P} and T{sub S}) and Bucky factors (B{sub f}). In addition, glare-to-primary ratios (GPRs) and scatter-to-primary ratios (SPRs) were quantified. The effect of the antiscatter grid on the signal-difference-to-noise ratio (SDNR) was also assessed. It was found that T{sub P} increases with kV but does not depend on the phantom thickness; T{sub P} values between 0.81 and 0.84 were measured. T{sub S} increases with kV and phantom thickness; T{sub S} values between 0.13 and 0.21 were measured. B{sub f} decreases with kV and increases with phantom thickness; B{sub f} ranges from 1.4 to 2.1. GPR is nearly constant, varying from 0.10 to 0.11. SPR without an antiscatter grid (SPR{sup -}) ranges from 0.35 to 1.34. SPR{sup -} decreases by approximately 9% from 35 to 49 kV for a given phantom thickness and is 3.5 times larger for an 80 mm thick breast-equivalent phantom than for a 20 mm thick breast-equivalent phantom. SPR with an antiscatter grid (SPR{sup +}) ranges from 0.06 to 0.31. SPR{sup +} increases by approximately 23% from 35 to 49 kV for a given phantom thickness; SPR{sup +} is four times larger for an 80 mm breast-equivalent phantom than for a 20 mm breast-equivalent phantom. When imaging a 25 mm PMMA plate at the same mean glandular dose with and without an antiscatter grid, the SDNR is 4% greater with a grid than without. For an 75mm PMMA plate, the SDNR is 20% greater with a grid. In conclusion, at the higher x-ray energy range used for CE-DM and CE-DBT, an antiscatter grid significantly reduces SPR and improves SDNR. These effects are most pronounced for thick breasts.« less
  • Purpose: The authors develop a practical, iterative algorithm for image-reconstruction in undersampled tomographic systems, such as digital breast tomosynthesis (DBT). Methods: The algorithm controls image regularity by minimizing the image total p variation (TpV), a function that reduces to the total variation when p=1.0 or the image roughness when p=2.0. Constraints on the image, such as image positivity and estimated projection-data tolerance, are enforced by projection onto convex sets. The fact that the tomographic system is undersampled translates to the mathematical property that many widely varied resultant volumes may correspond to a given data tolerance. Thus the application of imagemore » regularity serves two purposes: (1) Reduction in the number of resultant volumes out of those allowed by fixing the data tolerance, finding the minimum image TpV for fixed data tolerance, and (2) traditional regularization, sacrificing data fidelity for higher image regularity. The present algorithm allows for this dual role of image regularity in undersampled tomography. Results: The proposed image-reconstruction algorithm is applied to three clinical DBT data sets. The DBT cases include one with microcalcifications and two with masses. Conclusions: Results indicate that there may be a substantial advantage in using the present image-reconstruction algorithm for microcalcification imaging.« less