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Title: Design and construction of an optimized neutron beam shaping assembly for Boron Neutron Capture Therapy at the Tandar accelerator

Abstract

In this work we present an optimized neutron beam shaping assembly for epithermal Accelerator-Based Boron Neutron Capture Therapy (AB-BNCT) and discuss the simulations leading to its design.

Authors:
 [1];  [2];  [2];  [1];  [2];  [2]; ;  [1];  [3];  [2]
  1. Universidad de Gral San Martin (Argentina)
  2. (Argentina)
  3. Comision Nacional de Energia Atomica (Argentina)
Publication Date:
OSTI Identifier:
21054868
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 884; Journal Issue: 1; Conference: 6. Latin American symposium on nuclear physics and applications, Iguazu (Argentina), 3-7 Oct 2005; Other Information: DOI: 10.1063/1.2710630; (c) 2007 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; 43 PARTICLE ACCELERATORS; ACCELERATORS; BEAM PRODUCTION; BEAM SHAPING; BORON; COMPUTERIZED SIMULATION; CONSTRUCTION; DESIGN; NEUTRON BEAMS; NEUTRON CAPTURE THERAPY

Citation Formats

Burlon, A., Comision Nacional de Energia Atomica,, Fundacion Sauberan, Kreiner, A. J., Comision Nacional de Energia Atomica, CONICET, Valda, A. A., Somacal, H., Minsky, D. M., and Universidad de Gral San Martin. Design and construction of an optimized neutron beam shaping assembly for Boron Neutron Capture Therapy at the Tandar accelerator. United States: N. p., 2007. Web. doi:10.1063/1.2710630.
Burlon, A., Comision Nacional de Energia Atomica,, Fundacion Sauberan, Kreiner, A. J., Comision Nacional de Energia Atomica, CONICET, Valda, A. A., Somacal, H., Minsky, D. M., & Universidad de Gral San Martin. Design and construction of an optimized neutron beam shaping assembly for Boron Neutron Capture Therapy at the Tandar accelerator. United States. doi:10.1063/1.2710630.
Burlon, A., Comision Nacional de Energia Atomica,, Fundacion Sauberan, Kreiner, A. J., Comision Nacional de Energia Atomica, CONICET, Valda, A. A., Somacal, H., Minsky, D. M., and Universidad de Gral San Martin. Mon . "Design and construction of an optimized neutron beam shaping assembly for Boron Neutron Capture Therapy at the Tandar accelerator". United States. doi:10.1063/1.2710630.
@article{osti_21054868,
title = {Design and construction of an optimized neutron beam shaping assembly for Boron Neutron Capture Therapy at the Tandar accelerator},
author = {Burlon, A. and Comision Nacional de Energia Atomica, and Fundacion Sauberan and Kreiner, A. J. and Comision Nacional de Energia Atomica and CONICET and Valda, A. A. and Somacal, H. and Minsky, D. M. and Universidad de Gral San Martin},
abstractNote = {In this work we present an optimized neutron beam shaping assembly for epithermal Accelerator-Based Boron Neutron Capture Therapy (AB-BNCT) and discuss the simulations leading to its design.},
doi = {10.1063/1.2710630},
journal = {AIP Conference Proceedings},
number = 1,
volume = 884,
place = {United States},
year = {Mon Feb 12 00:00:00 EST 2007},
month = {Mon Feb 12 00:00:00 EST 2007}
}
  • In the frame of the construction of a Tandem Electrostatic Quadrupole Accelerator facility devoted to the Accelerator-Based Boron Neutron Capture Therapy, a Beam Shaping Assembly has been characterized by means of Monte-Carlo simulations and measurements. The neutrons were generated via the {sup 7}Li(p, n){sup 7}Be reaction by irradiating a thick LiF target with a 2.3 MeV proton beam delivered by the TANDAR accelerator at CNEA. The emerging neutron flux was measured by means of activation foils while the beam quality and directionality was evaluated by means of Monte Carlo simulations. The parameters show compliance with those suggested by IAEA. Finally,more » an improvement adding a beam collimator has been evaluated.« less
  • Purpose: To design a beam shaping assembly (BSA) to shape the 2.45-MeV neutrons produced by a deuterium-deuterium (DD) neutron generator and to optimize the beam output for boron neutron capture therapy of brain tumors Methods: MCNP is used for this simulation study. The simulation model consists of a neutron surface source that resembles an actual DD source and is surrounded by a BSA. The neutron source emits 2.45-MeV neutrons isotropically. The BSA is composed of a moderator, reflector, collimator and filter. Various types of materials and geometries are tested for each component to optimize the neutron output. Neutron characteristics aremore » measured with an 2×2×2-cm{sup 3} air-equivalent cylinder at the beam exit. The ideal BSA is determined by evaluating the in-air parameters, which include epithermal neutron per source neutron, fast neutron dose per epithermal neutron, and photon dose per epithermal neutron. The parameter values are compared to those recommended by the IAEA. Results: The ideal materials for reflector and thermal neutron filter were lead and cadmium, respectively. The thickness for reflector was 43 cm and for filter was 0.5 mm. At present, the best-performing moderator has 25 cm of AlF{sub 3} and 5 cm of MgF{sub 2}. This layout creates a neutron spectrum that has a peak at approximately 10 keV and produces 1.35E-4 epithermal neutrons per source neutron per cm{sup 2}. Additional neutron characteristics, fast neutrons per epithermal neutron and photon per epithermal neutron, are still under investigation. Conclusion: Working is ongoing to optimize the final layout of the BSA. The neutron spectrum at the beam exit window of the final configuration will have the maximum number of epithermal neutrons and limited photon and fast neutron contaminations within the recommended values by IAEA. Future studies will also include phantom experiments to validate the simulation results.« less
  • This work assesses the feasibility of using a small, safe, and inexpensive keff 0.98 subcritical fission assembly [subcritical neutron multiplier (SCM)] to amplify the treatment neutron beam intensity attainable from a compact deuterium-deuterium (D-D) fusion neutron source delivering [approximately]1012 n/s. The objective is to reduce the treatment time for deep-seated brain tumors to [approximately]1 h. The paper describes the optimal SCM design and two optimal beam-shaping assemblies (BSAs) - one designed to maximize the dose rate and the other designed to maximize the total dose that can be delivered to a deep-seated tumor. The neutron beam intensity amplification achieved withmore » the optimized SCM and BSA results in an increase in the treatment dose rate by a factor of 18: from 0.56 Gy/h without the SCM to 10.1 Gy/h. The entire SCM is encased in an aluminum structure. The total amount of 20% enriched uranium required for the SCM is 8.5 kg, and the cost (not including fabrication) is estimated to be less than $60,000. The SCM power level is estimated at 400 W when driven by a 1012 n/s D-D neutron source. This translates into consumption of only [approximately]0.6% of the initially loaded 235U atoms during 50 years of continuous operation and implies that the SCM could operate continuously for the entire lifetime of the facility without refueling. Cooling the SCM does not pose a challenge; it may be accomplished by natural circulation as the maximum heat flux is only 0.034 W/cm2.« less
  • A neutron-beam-shaping assembly consisting of a moderator, a reflector, and an absorber is used to form a therapeutic neutron beam for the boron neutron-capture therapy of malignant tumors at accelerator neutron sources. A new structure of the moderator and reflector is proposed in the present article, and the results of a numerical simulation of the neutron spectrum and of the absorbed dose in a modified Snyder head phantom are presented. The application of a composite moderator and of a composite reflector and the implementation of neutron production at the proton energy of 2.3MeV are shown to permit obtaining a high-qualitymore » therapeutic neutron beam.« less
  • Short communication.