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Title: Impaired capsule formation of tumors in periostin-null mice

Abstract

Being a secreted protein, periostin is a multifunctional matricellular glycoprotein. In vitro, periostin has the ability to promote the proliferation and migration of fibroblasts. Previously, it was demonstrated that periostin is mainly produced by cancer-associated fibroblasts or tumor stromal cells. In the present study, we show that periostin regulates capsule formation in a positive manner and inhibits tumor growth. Consistent with a previous finding, several tumor cell lines did not exhibit expression of periostin in vitro or in vivo; and the growth of tumors that had been allografted into periostin -/- mice was significantly accelerated compared with that of the same kind of tumors grafted into periostin +/+ mice. Immunostaining and biochemical analyses revealed that mature collagen was detected abundantly in the capsules and interstitium of the wild-type-grafted tumors but not in those of the periostin -/- grafted tumors. Moreover, the number of activated tumor stromal cells was decreased significantly in the periostin -/- grafted tumors. Our studies suggest that host-derived periostin negatively regulates tumor growth by promoting capsule formation and by mediating changes in the deposition and organization of the tumor microenvironment coordinated by periostin-producing stromal cells.

Authors:
 [1];  [1]
  1. Department of Biological Information, Tokyo Institute of Technology, 4259-B-33 Nagatsuta, Midori-ku, Yokohama 226-8501 (Japan)
Publication Date:
OSTI Identifier:
21043663
Resource Type:
Journal Article
Journal Name:
Biochemical and Biophysical Research Communications
Additional Journal Information:
Journal Volume: 367; Journal Issue: 4; Other Information: DOI: 10.1016/j.bbrc.2008.01.009; PII: S0006-291X(08)00017-X; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0006-291X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; CELL PROLIFERATION; COLLAGEN; FIBROBLASTS; GLYCOPROTEINS; GROWTH; IN VITRO; IN VIVO; MICE; NEOPLASMS; TUMOR CELLS

Citation Formats

Shimazaki, Masashi, and Kudo, Akira. Impaired capsule formation of tumors in periostin-null mice. United States: N. p., 2008. Web. doi:10.1016/j.bbrc.2008.01.009.
Shimazaki, Masashi, & Kudo, Akira. Impaired capsule formation of tumors in periostin-null mice. United States. https://doi.org/10.1016/j.bbrc.2008.01.009
Shimazaki, Masashi, and Kudo, Akira. 2008. "Impaired capsule formation of tumors in periostin-null mice". United States. https://doi.org/10.1016/j.bbrc.2008.01.009.
@article{osti_21043663,
title = {Impaired capsule formation of tumors in periostin-null mice},
author = {Shimazaki, Masashi and Kudo, Akira},
abstractNote = {Being a secreted protein, periostin is a multifunctional matricellular glycoprotein. In vitro, periostin has the ability to promote the proliferation and migration of fibroblasts. Previously, it was demonstrated that periostin is mainly produced by cancer-associated fibroblasts or tumor stromal cells. In the present study, we show that periostin regulates capsule formation in a positive manner and inhibits tumor growth. Consistent with a previous finding, several tumor cell lines did not exhibit expression of periostin in vitro or in vivo; and the growth of tumors that had been allografted into periostin -/- mice was significantly accelerated compared with that of the same kind of tumors grafted into periostin +/+ mice. Immunostaining and biochemical analyses revealed that mature collagen was detected abundantly in the capsules and interstitium of the wild-type-grafted tumors but not in those of the periostin -/- grafted tumors. Moreover, the number of activated tumor stromal cells was decreased significantly in the periostin -/- grafted tumors. Our studies suggest that host-derived periostin negatively regulates tumor growth by promoting capsule formation and by mediating changes in the deposition and organization of the tumor microenvironment coordinated by periostin-producing stromal cells.},
doi = {10.1016/j.bbrc.2008.01.009},
url = {https://www.osti.gov/biblio/21043663}, journal = {Biochemical and Biophysical Research Communications},
issn = {0006-291X},
number = 4,
volume = 367,
place = {United States},
year = {Fri Mar 21 00:00:00 EDT 2008},
month = {Fri Mar 21 00:00:00 EDT 2008}
}