skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: High Quality Image of Biomedical Object by X-ray Refraction Based Contrast Computed Tomography

Abstract

Recently we have developed a new Computed Tomography (CT) algorithm for refraction contrast that uses the optics of diffraction-enhanced imaging. We applied this new method to visualize soft tissue which is not visualized by the current absorption based contrast. The meaning of the contrast that appears in refraction-contrast X-ray CT images must be clarified from a biologic or anatomic point of view. It has been reported that the contrast is made with the specific gravity map with a range of approximately 10 {mu}arc sec. However, the relationship between the contrast and biologic or anatomic findings has not been investigated, to our knowledge. We compared refraction-contrast X-ray CT images with microscopic X-ray images, and we evaluated refractive indexes of pathologic lesions on phase-contrast X-ray CT images. We focused our attenuation of breast cancer and lung cancer as samples. X-ray refraction based Computed Tomography was appeared to be a pathological ability to depict the boundary between cancer nest and normal tissue, and inner structure of the disease.

Authors:
 [1]; ; ;  [2];  [1];  [3];  [4]; ;  [5];  [6];  [7];  [8];  [1];  [3];  [9]
  1. Department of Photon-Science, School of Advanced Studies, Graduate University for Advanced Studies (GUAS), Shonan Village, Hayama, Kanagawa 240-0193 (Japan)
  2. Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization (KEK), 1-1 Oho, Tsukuba, Ibaraki 305-0801 (Japan)
  3. (KEK), 1-1 Oho, Tsukuba, Ibaraki 305-0801 (Japan)
  4. Department of Health Sciences, Ibaraki prefectural University of Health Sciences, 4669-2Ami, Ami, Inashiki, Ibaraki, 300-0394 (Japan)
  5. RIKEN Harima Institute, 1-1-1 Kouto, Mikazuki, Sayo, Hyogo, 679-5148 (Japan)
  6. Department of Bio-system Engineering, Faculty of Engineering Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata 992-8510 (Japan)
  7. Dept. of Path., Nagoya Med. Center, Nat. Hospital Organization, Naka-ku, Nagoya 460-0001 (Japan)
  8. Matsumoto Dental University, 1980 Hirooka, Shiojiri, Nagano (Japan)
  9. (Japan)
Publication Date:
OSTI Identifier:
21043413
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 879; Journal Issue: 1; Conference: 9. international conference on synchrotron radiation instrumentation, Daegu (Korea, Republic of), 28 May - 2 Jun 2006; Other Information: DOI: 10.1063/1.2436463; (c) 2007 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ABSORPTION; ALGORITHMS; ATTENUATION; BIOLOGICAL MATERIALS; CAT SCANNING; IMAGES; LUNGS; MAMMARY GLANDS; NEOPLASMS; REFRACTIVE INDEX; X RADIATION; X-RAY DIFFRACTION

Citation Formats

Hashimoto, E., Maksimenko, A., Hirano, K., Hyodo, K., Sugiyama, H., Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization, Shimao, D., Nishino, Y., Ishikawa, T., Yuasa, T., Ichihara, S., Arai, Y., Ando, M., Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization, and Inst. of Sci. and Tech., Tokyo Univ. of Science, Yamasaki 2641, Noda, Chiba 278-8510. High Quality Image of Biomedical Object by X-ray Refraction Based Contrast Computed Tomography. United States: N. p., 2007. Web. doi:10.1063/1.2436463.
Hashimoto, E., Maksimenko, A., Hirano, K., Hyodo, K., Sugiyama, H., Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization, Shimao, D., Nishino, Y., Ishikawa, T., Yuasa, T., Ichihara, S., Arai, Y., Ando, M., Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization, & Inst. of Sci. and Tech., Tokyo Univ. of Science, Yamasaki 2641, Noda, Chiba 278-8510. High Quality Image of Biomedical Object by X-ray Refraction Based Contrast Computed Tomography. United States. doi:10.1063/1.2436463.
Hashimoto, E., Maksimenko, A., Hirano, K., Hyodo, K., Sugiyama, H., Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization, Shimao, D., Nishino, Y., Ishikawa, T., Yuasa, T., Ichihara, S., Arai, Y., Ando, M., Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization, and Inst. of Sci. and Tech., Tokyo Univ. of Science, Yamasaki 2641, Noda, Chiba 278-8510. Fri . "High Quality Image of Biomedical Object by X-ray Refraction Based Contrast Computed Tomography". United States. doi:10.1063/1.2436463.
@article{osti_21043413,
title = {High Quality Image of Biomedical Object by X-ray Refraction Based Contrast Computed Tomography},
author = {Hashimoto, E. and Maksimenko, A. and Hirano, K. and Hyodo, K. and Sugiyama, H. and Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization and Shimao, D. and Nishino, Y. and Ishikawa, T. and Yuasa, T. and Ichihara, S. and Arai, Y. and Ando, M. and Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization and Inst. of Sci. and Tech., Tokyo Univ. of Science, Yamasaki 2641, Noda, Chiba 278-8510},
abstractNote = {Recently we have developed a new Computed Tomography (CT) algorithm for refraction contrast that uses the optics of diffraction-enhanced imaging. We applied this new method to visualize soft tissue which is not visualized by the current absorption based contrast. The meaning of the contrast that appears in refraction-contrast X-ray CT images must be clarified from a biologic or anatomic point of view. It has been reported that the contrast is made with the specific gravity map with a range of approximately 10 {mu}arc sec. However, the relationship between the contrast and biologic or anatomic findings has not been investigated, to our knowledge. We compared refraction-contrast X-ray CT images with microscopic X-ray images, and we evaluated refractive indexes of pathologic lesions on phase-contrast X-ray CT images. We focused our attenuation of breast cancer and lung cancer as samples. X-ray refraction based Computed Tomography was appeared to be a pathological ability to depict the boundary between cancer nest and normal tissue, and inner structure of the disease.},
doi = {10.1063/1.2436463},
journal = {AIP Conference Proceedings},
number = 1,
volume = 879,
place = {United States},
year = {Fri Jan 19 00:00:00 EST 2007},
month = {Fri Jan 19 00:00:00 EST 2007}
}