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Title: On Detailed Contrast of Biomedical Object in X-ray Dark-Field Imaging

Abstract

Over the past 10 years, refraction-based X-ray imaging has been studied together with a perspective view to clinical application. X-ray Dark-Field Imaging that utilizes a Laue geometry analyzer has recently been proposed and has the proven ability to depict articular cartilage in an intact human finger. In the current study, we researched detailed image contrast using X-ray Dark-Field Imaging by observing the edge contrast of an acrylic rod as a simple case, and found differences in image contrast between the right and left edges of the rod. This effect could cause undesirable contrast in the thin articular cartilage on the head of the phalanx. To avoid overlapping with this contrast at the articular cartilage, which would lead to a wrong diagnosis, we suggest that a joint surface on which articular cartilage is located should be aligned in the same sense as the scattering vector of the Laue case analyzer crystal. Defects of articular cartilage were successfully detected under this condition. When utilized under appropriate imaging conditions, X-ray Dark-Field Imaging will be a powerful tool for the diagnosis of arthropathy, as minute changes in articular cartilage may be early-stage features of this disease.

Authors:
;  [1];  [2];  [3];  [4];  [2];  [2];  [3];  [3]
  1. Department of Radiological Sciences, Ibaraki Prefectural University of Health Sciences, Ami4669-2, Inashiki, Ibaraki, 300-0394 (Japan)
  2. Photon Factory, institute of Materials Structure Science, High Energy Accelerator Research Organization, Oho 1-1, Tsukuba, Ibaraki 305-0801 (Japan)
  3. (Japan)
  4. Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine and Dentistry, Shikata-cho 2-5-1 Okayama 700-8558 (Japan)
Publication Date:
OSTI Identifier:
21043408
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 879; Journal Issue: 1; Conference: 9. international conference on synchrotron radiation instrumentation, Daegu (Korea, Republic of), 28 May - 2 Jun 2006; Other Information: DOI: 10.1063/1.2436458; (c) 2007 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARTILAGE; CONTRAST MEDIA; CRYSTAL DEFECTS; DIAGNOSIS; DISEASES; GEOMETRY; IMAGES; REFRACTION; X RADIATION; X-RAY DIFFRACTION

Citation Formats

Shimao, Daisuke, Mori, Koichi, Sugiyama, Hiroshi, Department of Photo-Science, School of Advanced Studies, Graduate University for Advanced Studies, International Village, Hayama, Kanagawa 240-0193, Kunisada, Toshiyuki, Hyodo, Kazuyuki, Ando, Masami, Department of Photo-Science, School of Advanced Studies, Graduate University for Advanced Studies, International Village, Hayama, Kanagawa 240-0193, and Research Institute for Science and technology, Tokyo University of Science, Yamasaki 2641, Noda, Chiba 278-8510. On Detailed Contrast of Biomedical Object in X-ray Dark-Field Imaging. United States: N. p., 2007. Web. doi:10.1063/1.2436458.
Shimao, Daisuke, Mori, Koichi, Sugiyama, Hiroshi, Department of Photo-Science, School of Advanced Studies, Graduate University for Advanced Studies, International Village, Hayama, Kanagawa 240-0193, Kunisada, Toshiyuki, Hyodo, Kazuyuki, Ando, Masami, Department of Photo-Science, School of Advanced Studies, Graduate University for Advanced Studies, International Village, Hayama, Kanagawa 240-0193, & Research Institute for Science and technology, Tokyo University of Science, Yamasaki 2641, Noda, Chiba 278-8510. On Detailed Contrast of Biomedical Object in X-ray Dark-Field Imaging. United States. doi:10.1063/1.2436458.
Shimao, Daisuke, Mori, Koichi, Sugiyama, Hiroshi, Department of Photo-Science, School of Advanced Studies, Graduate University for Advanced Studies, International Village, Hayama, Kanagawa 240-0193, Kunisada, Toshiyuki, Hyodo, Kazuyuki, Ando, Masami, Department of Photo-Science, School of Advanced Studies, Graduate University for Advanced Studies, International Village, Hayama, Kanagawa 240-0193, and Research Institute for Science and technology, Tokyo University of Science, Yamasaki 2641, Noda, Chiba 278-8510. Fri . "On Detailed Contrast of Biomedical Object in X-ray Dark-Field Imaging". United States. doi:10.1063/1.2436458.
@article{osti_21043408,
title = {On Detailed Contrast of Biomedical Object in X-ray Dark-Field Imaging},
author = {Shimao, Daisuke and Mori, Koichi and Sugiyama, Hiroshi and Department of Photo-Science, School of Advanced Studies, Graduate University for Advanced Studies, International Village, Hayama, Kanagawa 240-0193 and Kunisada, Toshiyuki and Hyodo, Kazuyuki and Ando, Masami and Department of Photo-Science, School of Advanced Studies, Graduate University for Advanced Studies, International Village, Hayama, Kanagawa 240-0193 and Research Institute for Science and technology, Tokyo University of Science, Yamasaki 2641, Noda, Chiba 278-8510},
abstractNote = {Over the past 10 years, refraction-based X-ray imaging has been studied together with a perspective view to clinical application. X-ray Dark-Field Imaging that utilizes a Laue geometry analyzer has recently been proposed and has the proven ability to depict articular cartilage in an intact human finger. In the current study, we researched detailed image contrast using X-ray Dark-Field Imaging by observing the edge contrast of an acrylic rod as a simple case, and found differences in image contrast between the right and left edges of the rod. This effect could cause undesirable contrast in the thin articular cartilage on the head of the phalanx. To avoid overlapping with this contrast at the articular cartilage, which would lead to a wrong diagnosis, we suggest that a joint surface on which articular cartilage is located should be aligned in the same sense as the scattering vector of the Laue case analyzer crystal. Defects of articular cartilage were successfully detected under this condition. When utilized under appropriate imaging conditions, X-ray Dark-Field Imaging will be a powerful tool for the diagnosis of arthropathy, as minute changes in articular cartilage may be early-stage features of this disease.},
doi = {10.1063/1.2436458},
journal = {AIP Conference Proceedings},
number = 1,
volume = 879,
place = {United States},
year = {Fri Jan 19 00:00:00 EST 2007},
month = {Fri Jan 19 00:00:00 EST 2007}
}
  • Recently we have developed a new Computed Tomography (CT) algorithm for refraction contrast that uses the optics of diffraction-enhanced imaging. We applied this new method to visualize soft tissue which is not visualized by the current absorption based contrast. The meaning of the contrast that appears in refraction-contrast X-ray CT images must be clarified from a biologic or anatomic point of view. It has been reported that the contrast is made with the specific gravity map with a range of approximately 10 {mu}arc sec. However, the relationship between the contrast and biologic or anatomic findings has not been investigated, tomore » our knowledge. We compared refraction-contrast X-ray CT images with microscopic X-ray images, and we evaluated refractive indexes of pathologic lesions on phase-contrast X-ray CT images. We focused our attenuation of breast cancer and lung cancer as samples. X-ray refraction based Computed Tomography was appeared to be a pathological ability to depict the boundary between cancer nest and normal tissue, and inner structure of the disease.« less
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  • If an x-ray beam containing internal information derived from sample soft tissue is incident upon a Laue-case analyzer, the beam will subsequently split into a forwardly diffracted beam and a separate diffracted beam. Using these beams acquired simultaneously, a refraction-contrast computed tomography (CT) imaging system for biomedical use with lower radiation dose can be easily realized, and has a high depicting capability on the soft tissues compared with conventional x-ray CT based on absorption contrast principles. In this paper, we propose an imaging system using dark-field imaging for CT measurement based on a tandem system of Bragg- and Laue-case crystalsmore » with two two-dimensional detectors, along with a data-processing method to extract information on refraction from the measured entangled intensities by use of rocking curve fitting with polynomial functions. Reconstructed images of soft tissues are presented and described.« less
  • Following the first experimental demonstration of x-ray speckle-based multimodal imaging using a polychromatic beam [I. Zanette et al., Phys. Rev. Lett. 112(25), 253903 (2014)], we present a simulation study on the effects of a polychromatic x-ray spectrum on the performance of this technique. We observe that the contrast of the near-field speckles is only mildly influenced by the bandwidth of the energy spectrum. Moreover, using a homogeneous object with simple geometry, we characterize the beam hardening artifacts in the reconstructed transmission and refraction angle images, and we describe how the beam hardening also affects the dark-field signal provided by specklemore » tracking. This study is particularly important for further implementations and developments of coherent speckle-based techniques at laboratory x-ray sources.« less