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Title: Validity of Fusion Imaging of Hamster Heart obtained by Fluorescent and Phase-Contrast X-Ray CT with Synchrotron Radiation

Abstract

Fluorescent X-ray CT (FXCT) to depict functional information and phase-contrast X-ray CT (PCCT) to demonstrate morphological information are being developed to analyze the disease model of small animal. To understand the detailed pathological state, integration of both functional and morphological image is very useful. The feasibility of image fusion between FXCT and PCCT were examined by using ex-vivo hearts injected fatty acid metabolic agent (127I-BMIPP) in normal and cardiomyopathic hamsters. Fusion images were reconstructed from each 3D image of FXCT and PCCT. 127I-BMIPP distribution within the heart was clearly demonstrated by FXCT with 0.25 mm spatial resolution. The detailed morphological image was obtained by PCCT at about 0.03 mm spatial resolution. Using image integration technique, metabolic abnormality of fatty acid in cardiomyopathic myocardium was easily recognized corresponding to anatomical structures. Our study suggests that image fusion provides important biomedical information even in FXCT and PCCT imaging.

Authors:
; ; ; ;  [1]; ; ; ; ; ; ;  [2];  [3];  [4]
  1. Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575 (Japan)
  2. Faculty of Engineering, Yamagata University, Yonezawa, Yamagata 992-8510 (Japan)
  3. Institute of Material Science, High Energy Accelerator Research Organization, Tsukuba, Ibaraki 305-0801 (Japan)
  4. Department of Computer Science and Engineering, Nagoya Institute of Technology, Nagoya, Aichi 466-8555 (Japan)
Publication Date:
OSTI Identifier:
21043407
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 879; Journal Issue: 1; Conference: 9. international conference on synchrotron radiation instrumentation, Daegu (Korea, Republic of), 28 May - 2 Jun 2006; Other Information: DOI: 10.1063/1.2436457; (c) 2007 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; CARBOXYLIC ACIDS; COMPUTERIZED TOMOGRAPHY; DISEASES; DISTRIBUTION; HAMSTERS; IMAGES; IODINE 127; MYOCARDIUM; SPATIAL RESOLUTION; SYNCHROTRON RADIATION; X RADIATION

Citation Formats

Wu, J., Takeda, T., Lwin, Thet Thet, Huo, Q., Minami, M., Sunaguchi, N., Murakami, T., Mouri, S., Nasukawa, S., Fukami, T., Yuasa, T., Akatsuka, T., Hyodo, K., and Hontani, H. Validity of Fusion Imaging of Hamster Heart obtained by Fluorescent and Phase-Contrast X-Ray CT with Synchrotron Radiation. United States: N. p., 2007. Web. doi:10.1063/1.2436457.
Wu, J., Takeda, T., Lwin, Thet Thet, Huo, Q., Minami, M., Sunaguchi, N., Murakami, T., Mouri, S., Nasukawa, S., Fukami, T., Yuasa, T., Akatsuka, T., Hyodo, K., & Hontani, H. Validity of Fusion Imaging of Hamster Heart obtained by Fluorescent and Phase-Contrast X-Ray CT with Synchrotron Radiation. United States. doi:10.1063/1.2436457.
Wu, J., Takeda, T., Lwin, Thet Thet, Huo, Q., Minami, M., Sunaguchi, N., Murakami, T., Mouri, S., Nasukawa, S., Fukami, T., Yuasa, T., Akatsuka, T., Hyodo, K., and Hontani, H. Fri . "Validity of Fusion Imaging of Hamster Heart obtained by Fluorescent and Phase-Contrast X-Ray CT with Synchrotron Radiation". United States. doi:10.1063/1.2436457.
@article{osti_21043407,
title = {Validity of Fusion Imaging of Hamster Heart obtained by Fluorescent and Phase-Contrast X-Ray CT with Synchrotron Radiation},
author = {Wu, J. and Takeda, T. and Lwin, Thet Thet and Huo, Q. and Minami, M. and Sunaguchi, N. and Murakami, T. and Mouri, S. and Nasukawa, S. and Fukami, T. and Yuasa, T. and Akatsuka, T. and Hyodo, K. and Hontani, H.},
abstractNote = {Fluorescent X-ray CT (FXCT) to depict functional information and phase-contrast X-ray CT (PCCT) to demonstrate morphological information are being developed to analyze the disease model of small animal. To understand the detailed pathological state, integration of both functional and morphological image is very useful. The feasibility of image fusion between FXCT and PCCT were examined by using ex-vivo hearts injected fatty acid metabolic agent (127I-BMIPP) in normal and cardiomyopathic hamsters. Fusion images were reconstructed from each 3D image of FXCT and PCCT. 127I-BMIPP distribution within the heart was clearly demonstrated by FXCT with 0.25 mm spatial resolution. The detailed morphological image was obtained by PCCT at about 0.03 mm spatial resolution. Using image integration technique, metabolic abnormality of fatty acid in cardiomyopathic myocardium was easily recognized corresponding to anatomical structures. Our study suggests that image fusion provides important biomedical information even in FXCT and PCCT imaging.},
doi = {10.1063/1.2436457},
journal = {AIP Conference Proceedings},
number = 1,
volume = 879,
place = {United States},
year = {Fri Jan 19 00:00:00 EST 2007},
month = {Fri Jan 19 00:00:00 EST 2007}
}