In-vivo Fluorescent X-ray CT Imaging of Mouse Brain

Journal Article · Fri Jan 19 00:00:00 EST 2007 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.2436454· OSTI ID:21043404

Takeda, T; Wu, J; Lwin, Thet-Thet; Huo, Q; Minami, M ^[1]; Sunaguchi, N; Murakami, T; Mouri, S; Nasukawa, S; Yuasa, T; Akatsuka, T ^[2]; Hyodo, K ^[3]; Hontani, H ^[4]

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1. Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575 (Japan)
2. Faculty of Engineering, Yamagata University, Yonezawa, Yamagata 992-8510 (Japan)
3. Institute of Material Science, High Energy Accelerator Research Organization, Tsukuba, Ibaraki 305-0801 (Japan)
4. Department of Computer Science and Engineering, Nagoya Institute of Technology, Nagoya, Aichi 466-8555 (Japan)

Using a non-radioactive iodine-127 labeled cerebral perfusion agent (I-127 IMP), fluorescent X-ray computed tomography (FXCT) clearly revealed the cross-sectional distribution of I-127 IMP in normal mouse brain in-vivo. Cerebral perfusion of cortex and basal ganglion was depicted with 1 mm in-plane spatial resolution and 0.1 mm slice thickness. Degree of cerebral perfusion in basal ganglion was about 2-fold higher than that in cortical regions. This result suggests that in-vivo cerebral perfusion imaging is realized quantitatively by FXCT at high volumetric resolution.

• OSTI ID: 21043404
• Journal Information: AIP Conference Proceedings, Vol. 879, Issue 1; Conference: 9. international conference on synchrotron radiation instrumentation, Daegu (Korea, Republic of), 28 May - 2 Jun 2006; Other Information: DOI: 10.1063/1.2436454; (c) 2007 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
BRAIN
COMPUTERIZED TOMOGRAPHY
DISTRIBUTION
GANGLIONS
IMAGES
IN VIVO
IODINE 127
LABELLED COMPOUNDS
MICE
SPATIAL RESOLUTION
X RADIATION