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Title: Dynamic Studies of Lung Fluid Clearance with Phase Contrast Imaging

Abstract

Clearance of liquid from the airways at birth is a poorly understood process, partly due to the difficulties of observing and measuring the distribution of air within the lung. Imaging dynamic processes within the lung in vivo with high contrast and spatial resolution is therefore a major challenge. However, phase contrast X-ray imaging is able to exploit inhaled air as a contrast agent, rendering the lungs of small animals visible due to the large changes in the refractive index at air/tissue interfaces. In concert with the high spatial resolution afforded by X-ray imaging systems (<100 {mu}m), propagation-based phase contrast imaging is ideal for studying lung development. To this end we have utilized intense, monochromatic synchrotron radiation, together with a fast readout CCD camera, to study fluid clearance from the lungs of rabbit pups at birth. Local rates of fluid clearance have been measured from the dynamic sequences using a single image phase retrieval algorithm.

Authors:
; ; ; ;  [1]; ;  [2]; ;  [3];  [1];  [4]; ;  [5]
  1. School of Physics, Monash University, Victoria 3800 (Australia)
  2. Monash Centre for Synchrotron Science, Monash University, Victoria 3800 (Australia)
  3. Department of Physiology, Monash University, Victoria 3800 (Australia)
  4. (Australia)
  5. SPring-8/JASRI, Mikazuki, Hyogo 679-5198 (Japan)
Publication Date:
OSTI Identifier:
21043394
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 879; Journal Issue: 1; Conference: 9. international conference on synchrotron radiation instrumentation, Daegu (Korea, Republic of), 28 May - 2 Jun 2006; Other Information: DOI: 10.1063/1.2436444; (c) 2007 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; AIR; ALGORITHMS; CAMERAS; CHARGE-COUPLED DEVICES; CONTRAST MEDIA; DISTRIBUTION; IMAGES; IN VIVO; INTERFACES; LIQUIDS; LUNGS; MONOCHROMATIC RADIATION; PARTURITION; RABBITS; READOUT SYSTEMS; REFRACTIVE INDEX; SPATIAL RESOLUTION; SYNCHROTRON RADIATION; X RADIATION

Citation Formats

Kitchen, Marcus J., Williams, Ivan, Irvine, Sarah C., Morgan, Michael J., Paganin, David M., Lewis, Rob A., Pavlov, Konstantin, Hooper, Stuart B., Wallace, Megan J., Siu, Karen K. W., Department of Medical Imaging and Radiation Science, Monash University, Victoria 3800, Yagi, Naoto, and Uesugi, Kentaro. Dynamic Studies of Lung Fluid Clearance with Phase Contrast Imaging. United States: N. p., 2007. Web. doi:10.1063/1.2436444.
Kitchen, Marcus J., Williams, Ivan, Irvine, Sarah C., Morgan, Michael J., Paganin, David M., Lewis, Rob A., Pavlov, Konstantin, Hooper, Stuart B., Wallace, Megan J., Siu, Karen K. W., Department of Medical Imaging and Radiation Science, Monash University, Victoria 3800, Yagi, Naoto, & Uesugi, Kentaro. Dynamic Studies of Lung Fluid Clearance with Phase Contrast Imaging. United States. doi:10.1063/1.2436444.
Kitchen, Marcus J., Williams, Ivan, Irvine, Sarah C., Morgan, Michael J., Paganin, David M., Lewis, Rob A., Pavlov, Konstantin, Hooper, Stuart B., Wallace, Megan J., Siu, Karen K. W., Department of Medical Imaging and Radiation Science, Monash University, Victoria 3800, Yagi, Naoto, and Uesugi, Kentaro. Fri . "Dynamic Studies of Lung Fluid Clearance with Phase Contrast Imaging". United States. doi:10.1063/1.2436444.
@article{osti_21043394,
title = {Dynamic Studies of Lung Fluid Clearance with Phase Contrast Imaging},
author = {Kitchen, Marcus J. and Williams, Ivan and Irvine, Sarah C. and Morgan, Michael J. and Paganin, David M. and Lewis, Rob A. and Pavlov, Konstantin and Hooper, Stuart B. and Wallace, Megan J. and Siu, Karen K. W. and Department of Medical Imaging and Radiation Science, Monash University, Victoria 3800 and Yagi, Naoto and Uesugi, Kentaro},
abstractNote = {Clearance of liquid from the airways at birth is a poorly understood process, partly due to the difficulties of observing and measuring the distribution of air within the lung. Imaging dynamic processes within the lung in vivo with high contrast and spatial resolution is therefore a major challenge. However, phase contrast X-ray imaging is able to exploit inhaled air as a contrast agent, rendering the lungs of small animals visible due to the large changes in the refractive index at air/tissue interfaces. In concert with the high spatial resolution afforded by X-ray imaging systems (<100 {mu}m), propagation-based phase contrast imaging is ideal for studying lung development. To this end we have utilized intense, monochromatic synchrotron radiation, together with a fast readout CCD camera, to study fluid clearance from the lungs of rabbit pups at birth. Local rates of fluid clearance have been measured from the dynamic sequences using a single image phase retrieval algorithm.},
doi = {10.1063/1.2436444},
journal = {AIP Conference Proceedings},
number = 1,
volume = 879,
place = {United States},
year = {Fri Jan 19 00:00:00 EST 2007},
month = {Fri Jan 19 00:00:00 EST 2007}
}