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Title: Synchrotron Radiation Mammography: Clinical Experimentation

Abstract

For several years a large variety of in-vitro medical imaging studies were carried out at the SYRMEP (Synchrotron Radiation for Medical Physics) beamline of the synchrotron radiation facility ELETTRA (Trieste, Italy) utilizing phase sensitive imaging techniques. In particular low dose Phase Contrast (PhC) in planar imaging mode and computed tomography were utilized for full field mammography. The results obtained on in-vitro samples at the SYRMEP beamline in PhC breast imaging were so encouraging that a clinical program on a limited number of patients selected by radiologists was launched to validate the improvements of synchrotron radiation in mammography. PhC mammography with conventional screen-film systems is the first step within this project. A digital system is under development for future applications. During the last years the entire beamline has been deeply modified and a medical facility dedicated to in-vivo mammography was constructed. The facility for PhC synchrotron radiation mammography is now operative in patient mode. The system reveals a prominent increase in image quality with respect to conventional mammograms even at lower delivered dose.

Authors:
; ; ; ;  [1];  [2]; ; ; ; ;  [3]; ;  [4]; ; ;  [5]
  1. Department of Physics, University of Trieste, Via A. Valerio 2, 34127 Trieste (Italy)
  2. (Italy)
  3. Sincrotrone Trieste SCpA, S.S. 14 km 163.5, 34012 Basovizza, Trieste (Italy)
  4. Health Physics, Hospital, Via Pieta 19, Trieste (Italy)
  5. Department of Radiology, University and Hospital, St. di Fiume 447, 34139 Trieste (Italy)
Publication Date:
OSTI Identifier:
21043392
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 879; Journal Issue: 1; Conference: 9. international conference on synchrotron radiation instrumentation, Daegu (Korea, Republic of), 28 May - 2 Jun 2006; Other Information: DOI: 10.1063/1.2436442; (c) 2007 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BIOMEDICAL RADIOGRAPHY; COMPUTERIZED TOMOGRAPHY; DIGITAL SYSTEMS; DOSES; FILMS; IMAGES; IN VITRO; IN VIVO; ITALY; MAMMARY GLANDS; PATIENTS; SYNCHROTRON RADIATION; X RADIATION

Citation Formats

Arfelli, Fulvia, Dreossi, Diego, Longo, Renata, Rokvic, Tatjana, Castelli, Edoardo, INFN, Via A. Valerio 2, 34127 Trieste, Abrami, Alessandro, Chenda, Valentina, Menk, Ralf-Hendrik, Quai, Elisa, Tromba, Giuliana, Bregant, Paola, De Guarrini, Fabio, Cova, Maria A., Tonutti, Maura, and Zanconati, Fabrizio. Synchrotron Radiation Mammography: Clinical Experimentation. United States: N. p., 2007. Web. doi:10.1063/1.2436442.
Arfelli, Fulvia, Dreossi, Diego, Longo, Renata, Rokvic, Tatjana, Castelli, Edoardo, INFN, Via A. Valerio 2, 34127 Trieste, Abrami, Alessandro, Chenda, Valentina, Menk, Ralf-Hendrik, Quai, Elisa, Tromba, Giuliana, Bregant, Paola, De Guarrini, Fabio, Cova, Maria A., Tonutti, Maura, & Zanconati, Fabrizio. Synchrotron Radiation Mammography: Clinical Experimentation. United States. doi:10.1063/1.2436442.
Arfelli, Fulvia, Dreossi, Diego, Longo, Renata, Rokvic, Tatjana, Castelli, Edoardo, INFN, Via A. Valerio 2, 34127 Trieste, Abrami, Alessandro, Chenda, Valentina, Menk, Ralf-Hendrik, Quai, Elisa, Tromba, Giuliana, Bregant, Paola, De Guarrini, Fabio, Cova, Maria A., Tonutti, Maura, and Zanconati, Fabrizio. Fri . "Synchrotron Radiation Mammography: Clinical Experimentation". United States. doi:10.1063/1.2436442.
@article{osti_21043392,
title = {Synchrotron Radiation Mammography: Clinical Experimentation},
author = {Arfelli, Fulvia and Dreossi, Diego and Longo, Renata and Rokvic, Tatjana and Castelli, Edoardo and INFN, Via A. Valerio 2, 34127 Trieste and Abrami, Alessandro and Chenda, Valentina and Menk, Ralf-Hendrik and Quai, Elisa and Tromba, Giuliana and Bregant, Paola and De Guarrini, Fabio and Cova, Maria A. and Tonutti, Maura and Zanconati, Fabrizio},
abstractNote = {For several years a large variety of in-vitro medical imaging studies were carried out at the SYRMEP (Synchrotron Radiation for Medical Physics) beamline of the synchrotron radiation facility ELETTRA (Trieste, Italy) utilizing phase sensitive imaging techniques. In particular low dose Phase Contrast (PhC) in planar imaging mode and computed tomography were utilized for full field mammography. The results obtained on in-vitro samples at the SYRMEP beamline in PhC breast imaging were so encouraging that a clinical program on a limited number of patients selected by radiologists was launched to validate the improvements of synchrotron radiation in mammography. PhC mammography with conventional screen-film systems is the first step within this project. A digital system is under development for future applications. During the last years the entire beamline has been deeply modified and a medical facility dedicated to in-vivo mammography was constructed. The facility for PhC synchrotron radiation mammography is now operative in patient mode. The system reveals a prominent increase in image quality with respect to conventional mammograms even at lower delivered dose.},
doi = {10.1063/1.2436442},
journal = {AIP Conference Proceedings},
number = 1,
volume = 879,
place = {United States},
year = {Fri Jan 19 00:00:00 EST 2007},
month = {Fri Jan 19 00:00:00 EST 2007}
}
  • Preliminary experiments have been carried out on the X27C R&D beamline at the National Synchrotron Light Source (NSLS) to explore the potential improvement in contrast in breast imaging using monochromatic synchrotron x-rays [R. E. Johnson {ital et} {ital al}., SPIE (1995) (to be published)]. In our present study, images have been obtained of ACR, contrast detail and anthropomorphic phantoms at 16 to 24 keV. Phantom thickness varied from 42 to 80 mm. Synchrotron images using a Fuji image plate detector and standard mammographic film have been compared to each other and with conventionally produced images. The preliminary results show anmore » improved contrast over the conventional images with lower absorbed dose in the phantoms. The image plate detector was used for our fist experiments because it was readily available and produces digital data. Experiments using an additional analyzer crystal as a scatter rejection element are also underway at the NSLS [D. Chapman, SRI {open_quote}95 (these proceedings)]. We plan to evaluate a variety of detectors and monochromatic beam geometries in order to develop a system that optimizes mammography image contrast and spatial resolution. {copyright} {ital 1996 American Institute of Physics.}« less
  • For the first time in the literature, radiographs of breast phantoms were obtained using several monochromatic synchrotron radiation x-ray beams of selected energy in the range from 14 to 26 keV. In addition, after optimization of the photon energy as a function of the phantom thickness, several mammographs were obtained on surgically removed human breast specimens containing cancer nodules. Comparison between radiographs using a conventional x-ray unit and those obtained of the same specimens utilizing synchrotron monochromatic beams clearly shows that higher contrast and better resolution can be achieved with synchrotron radiation. These results demonstrate the possibility of obtaining radiographsmore » of excised human breast tissue containing a greater amount of radiological information using synchrotron radiation.« less
  • The goal of the study was to evaluate the first CR digital mammography system ( registered Konica-Minolta) in Mexico in clinical routine for cancer detection in a screening population and to determine if high resolution CR digital imaging is equivalent to state-of-the-art screen-film imaging. The mammograms were evaluated by two observers with cytological or histological confirmation for BIRADS 3, 4 and 5. Contrast, exposure and artifacts of the images were evaluated. Different details like skin, retromamillary space and parenchymal structures were judged. The detectability of microcalcifications and lesions were compared and correlated to histology. The difference in sensitivity of CRmore » Mammography (CRM) and Screen Film Mammography (SFM) was not statistically significant. However, CRM had a significantly lower recall rate, and the lesion detection was equal or superior to conventional images. There is no significant difference in the number of microcalcifications and highly suspicious calcifications were equally detected on both film-screen and digital images. Different anatomical regions were better detectable in digital than in conventional mammography.« less
  • Purpose: An adequate dosimetry protocol for synchrotron radiation and the specific features of the ID17 Biomedical Beamline at the European Synchrotron Radiation Facility are essential for the preparation of the forthcoming clinical trials in the synchrotron stereotactic radiation therapy (SSRT). The main aim of this work is the definition of a suitable protocol based on standards of dose absorbed to water. It must allow measuring the absolute dose with an uncertainty within the recommended limits for patient treatment of 2%-5%. Methods: Absolute dosimetry is performed with a thimble ionization chamber (PTW semiflex 31002) whose center is positioned at 2 gmore » cm{sup -2} equivalent depth in water. Since the available synchrotron beam at the ESRF Biomedical Beamline has a maximum height of 3 mm, a scanning method was employed to mimic a uniform exposition of the ionization chamber. The scanning method has been shown to be equivalent to a broad beam irradiation. Different correction factors have been assessed by using Monte Carlo simulations. Results: The absolute dose absorbed to water at 80 keV was measured in reference conditions with a 2% global uncertainty, within the recommended limits. The dose rate was determined to be in the range between 14 and 18 Gy/min, that is to say, a factor two to three times higher than the 6 Gy/min achievable in RapidArc or VMAT machines. The dose absorbed to water was also measured in a RW3 solid water phantom. This phantom is suitable for quality assurance purposes since less than 2% average difference with respect to the water phantom measurements was found. In addition, output factors were assessed for different field sizes. Conclusions: A dosimetry protocol adequate for the specific features of the SSRT technique has been developed. This protocol allows measuring the absolute dose absorbed to water with an accuracy of 2%. It is therefore satisfactory for patient treatment.« less
  • Synchrotron radiation is an innovative tool for the treatment of brain tumors. In the stereotactic synchrotron radiation therapy (SSRT) technique a radiation dose enhancement specific to the tumor is obtained. The tumor is loaded with a high atomic number (Z) element and it is irradiated in stereotactic conditions from several entrance angles. The aim of this work was to assess dosimetric properties of the SSRT for preparing clinical trials at the European Synchrotron Radiation Facility (ESRF). To estimate the possible risks, the doses received by the tumor and healthy tissues in the future clinical conditions have been calculated by usingmore » Monte Carlo simulations (PENELOPE code). The dose enhancement factors have been determined for different iodine concentrations in the tumor, several tumor positions, tumor sizes, and different beam sizes. A scheme for the dose escalation in the various phases of the clinical trials has been proposed. The biological equivalent doses and the normalized total doses received by the skull have been calculated in order to assure that the tolerance values are not reached.« less