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Title: Patterns of Failure After MammoSite Brachytherapy Partial Breast Irradiation: A Detailed Analysis

Abstract

Purpose: To report the results of a detailed analysis of treatment failures after MammoSite breast brachytherapy for partial breast irradiation from our single-institution experience. Methods and Materials: Between October 14, 2002 and October 23, 2006, 78 patients with early-stage breast cancer were treated with breast-conserving surgery and accelerated partial breast irradiation using the MammoSite brachytherapy applicator. We identified five treatment failures in the 70 patients with >6 months' follow-up. Pathologic data, breast imaging, and radiation treatment plans were reviewed. For in-breast failures more than 2 cm away from the original surgical bed, the doses delivered to the areas of recurrence by partial breast irradiation were calculated. Results: At a median follow-up time of 26.1 months, five treatment failures were identified. There were three in-breast failures more than 2 cm away from the original surgical bed, one failure directly adjacent to the original surgical bed, and one failure in the axilla with synchronous distant metastases. The crude failure rate was 7.1% (5 of 70), and the crude local failure rate was 5.7% (4 of 70). Estimated progression-free survival at 48 months was 89.8% (standard error 4.5%). Conclusions: Our case series of 70 patients with >6 months' follow-up and a median follow-upmore » of 26 months is the largest single-institution report to date with detailed failure analysis associated with MammoSite brachytherapy. Our failure data emphasize the importance of patient selection when offering partial breast irradiation.« less

Authors:
 [1]; ; ;  [1]; ;  [2];  [1];  [3];  [4];  [1]
  1. Department of Radiation Oncology, Rush University Medical Center, Chicago, IL (United States)
  2. Department of Diagnostic Radiology and Nuclear Medicine, Rush University Medical Center, Chicago, IL (United States)
  3. Department of General Surgery, Rush University Medical Center, Chicago, IL (United States)
  4. Department of Radiation Oncology, Creighton University Medical Center, Omaha, NE (United States)
Publication Date:
OSTI Identifier:
21036194
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 69; Journal Issue: 1; Other Information: DOI: 10.1016/j.ijrobp.2007.02.057; PII: S0360-3016(07)00549-4; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRACHYTHERAPY; CARCINOMAS; ERRORS; FAILURES; IRRADIATION; MAMMARY GLANDS; METASTASES; PATIENTS; RADIATION DOSES; SURGERY

Citation Formats

Chen, Sea, Dickler, Adam, Kirk, Michael, Shah, Anand, Jokich, Peter, Solmos, Gene, Strauss, Jonathan, Dowlatshahi, Kambiz, Nguyen, Cam, and Griem, Katherine. Patterns of Failure After MammoSite Brachytherapy Partial Breast Irradiation: A Detailed Analysis. United States: N. p., 2007. Web. doi:10.1016/j.ijrobp.2007.02.057.
Chen, Sea, Dickler, Adam, Kirk, Michael, Shah, Anand, Jokich, Peter, Solmos, Gene, Strauss, Jonathan, Dowlatshahi, Kambiz, Nguyen, Cam, & Griem, Katherine. Patterns of Failure After MammoSite Brachytherapy Partial Breast Irradiation: A Detailed Analysis. United States. https://doi.org/10.1016/j.ijrobp.2007.02.057
Chen, Sea, Dickler, Adam, Kirk, Michael, Shah, Anand, Jokich, Peter, Solmos, Gene, Strauss, Jonathan, Dowlatshahi, Kambiz, Nguyen, Cam, and Griem, Katherine. 2007. "Patterns of Failure After MammoSite Brachytherapy Partial Breast Irradiation: A Detailed Analysis". United States. https://doi.org/10.1016/j.ijrobp.2007.02.057.
@article{osti_21036194,
title = {Patterns of Failure After MammoSite Brachytherapy Partial Breast Irradiation: A Detailed Analysis},
author = {Chen, Sea and Dickler, Adam and Kirk, Michael and Shah, Anand and Jokich, Peter and Solmos, Gene and Strauss, Jonathan and Dowlatshahi, Kambiz and Nguyen, Cam and Griem, Katherine},
abstractNote = {Purpose: To report the results of a detailed analysis of treatment failures after MammoSite breast brachytherapy for partial breast irradiation from our single-institution experience. Methods and Materials: Between October 14, 2002 and October 23, 2006, 78 patients with early-stage breast cancer were treated with breast-conserving surgery and accelerated partial breast irradiation using the MammoSite brachytherapy applicator. We identified five treatment failures in the 70 patients with >6 months' follow-up. Pathologic data, breast imaging, and radiation treatment plans were reviewed. For in-breast failures more than 2 cm away from the original surgical bed, the doses delivered to the areas of recurrence by partial breast irradiation were calculated. Results: At a median follow-up time of 26.1 months, five treatment failures were identified. There were three in-breast failures more than 2 cm away from the original surgical bed, one failure directly adjacent to the original surgical bed, and one failure in the axilla with synchronous distant metastases. The crude failure rate was 7.1% (5 of 70), and the crude local failure rate was 5.7% (4 of 70). Estimated progression-free survival at 48 months was 89.8% (standard error 4.5%). Conclusions: Our case series of 70 patients with >6 months' follow-up and a median follow-up of 26 months is the largest single-institution report to date with detailed failure analysis associated with MammoSite brachytherapy. Our failure data emphasize the importance of patient selection when offering partial breast irradiation.},
doi = {10.1016/j.ijrobp.2007.02.057},
url = {https://www.osti.gov/biblio/21036194}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 1,
volume = 69,
place = {United States},
year = {Sat Sep 01 00:00:00 EDT 2007},
month = {Sat Sep 01 00:00:00 EDT 2007}
}