Growth pattern switch of renal cells and expression of cell cycle related proteins at the early stage of diabetic nephropathy
- Department of Nephrology, Third Hospital, Hebei Medical University, Shijiazhuang 050051 (China)
- Department of Pathology, Hebei Medical University, Shijiazhuang, Hebei 050017 (China)
- Department of Dermatology, Third Hospital, Hebei Medical University, Shijiazhuang 050051 (China)
- Department of Neurology, Second Hospital, Hebei Medical University, Shijiazhuang 050003 (China)
Renal hypertrophy, partly due to cell proliferation and hypertrophy, has been found correlated to renal function deterioration in diabetes mellitus. We screened the up-regulated cell cycle related genes to investigate cell growth and the expression of cell cycle regulating proteins at the early stage of diabetic nephropathy using STZ-induced diabetic rats. Cyclin E, CDK{sub 2} and P{sup 27} were found significantly up-regulated in diabetic kidney. Increased cell proliferation in the kidney was seen at day 3, peaked at day 5, and returned to normal level at day 30. Cyclin E and CDK{sub 2} expression also peeked at day 5 and P{sup 27} activity peaked at day 14. These findings indicate that a hyperplastic growth period of renal cells is followed by a hypertrophic growth period at the early stage of diabetes. The growth pattern switch may be regulated by cell cycle regulating proteins, Cyclin E, CDK{sub 2}, and P{sup 27}.
- OSTI ID:
- 21032964
- Journal Information:
- Biochemical and Biophysical Research Communications, Vol. 363, Issue 1; Other Information: DOI: 10.1016/j.bbrc.2007.08.139; PII: S0006-291X(07)01874-8; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
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