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Title: Multiplexed operation of a micromachined ultrasonic droplet ejector array

Abstract

A dual-sample ultrasonic droplet ejector array is developed for use as a soft-ionization ion source for multiplexed mass spectrometry (MS). Such a multiplexed ion source aims to reduce MS analysis time for multiple analyte streams, as well as allow for the synchronized ejection of the sample(s) and an internal standard for quantitative results and mass calibration. Multiplexing is achieved at the device level by division of the fluid reservoir and separating the active electrodes of the piezoelectric transducer for isolated application of ultrasonic wave energy to each domain. The transducer is mechanically shaped to further reduce the acoustical crosstalk between the domains. Device design is performed using finite-element analysis simulations and supported by experimental characterization. Isolated ejection of {approx}5 {mu}m diameter water droplets from individual domains in the micromachined droplet ejector array at around 1 MHz frequency is demonstrated by experiments. The proof-of-concept demonstration using a dual-sample device also shows potential for multiplexing with larger numbers of analytes.

Authors:
; ;  [1]
  1. G. W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332 (United States)
Publication Date:
OSTI Identifier:
21024446
Resource Type:
Journal Article
Resource Relation:
Journal Name: Review of Scientific Instruments; Journal Volume: 78; Journal Issue: 10; Other Information: DOI: 10.1063/1.2785156; (c) 2007 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; CALIBRATION; DESIGN; DROPLETS; ELECTRODES; EQUIPMENT; FINITE ELEMENT METHOD; FLUIDS; ION SOURCES; IONIZATION; MASS SPECTROSCOPY; MHZ RANGE; OPERATION; PIEZOELECTRICITY; STREAMS; TRANSDUCERS; ULTRASONIC WAVES; WATER

Citation Formats

Forbes, Thomas P., Degertekin, F. Levent, and Fedorov, Andrei G. Multiplexed operation of a micromachined ultrasonic droplet ejector array. United States: N. p., 2007. Web. doi:10.1063/1.2785156.
Forbes, Thomas P., Degertekin, F. Levent, & Fedorov, Andrei G. Multiplexed operation of a micromachined ultrasonic droplet ejector array. United States. doi:10.1063/1.2785156.
Forbes, Thomas P., Degertekin, F. Levent, and Fedorov, Andrei G. Mon . "Multiplexed operation of a micromachined ultrasonic droplet ejector array". United States. doi:10.1063/1.2785156.
@article{osti_21024446,
title = {Multiplexed operation of a micromachined ultrasonic droplet ejector array},
author = {Forbes, Thomas P. and Degertekin, F. Levent and Fedorov, Andrei G.},
abstractNote = {A dual-sample ultrasonic droplet ejector array is developed for use as a soft-ionization ion source for multiplexed mass spectrometry (MS). Such a multiplexed ion source aims to reduce MS analysis time for multiple analyte streams, as well as allow for the synchronized ejection of the sample(s) and an internal standard for quantitative results and mass calibration. Multiplexing is achieved at the device level by division of the fluid reservoir and separating the active electrodes of the piezoelectric transducer for isolated application of ultrasonic wave energy to each domain. The transducer is mechanically shaped to further reduce the acoustical crosstalk between the domains. Device design is performed using finite-element analysis simulations and supported by experimental characterization. Isolated ejection of {approx}5 {mu}m diameter water droplets from individual domains in the micromachined droplet ejector array at around 1 MHz frequency is demonstrated by experiments. The proof-of-concept demonstration using a dual-sample device also shows potential for multiplexing with larger numbers of analytes.},
doi = {10.1063/1.2785156},
journal = {Review of Scientific Instruments},
number = 10,
volume = 78,
place = {United States},
year = {Mon Oct 15 00:00:00 EDT 2007},
month = {Mon Oct 15 00:00:00 EDT 2007}
}