Structural properties of a family of hydrogen-bonded co-crystals formed between gemfibrozil and hydroxy derivatives of t-butylamine, determined directly from powder X-ray diffraction data
- School of Chemistry, Cardiff University, Park Place, Cardiff CF10 3AT, Wales (United Kingdom)
- School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET (United Kingdom)
- Bristol-Myers Squibb, Pharmaceutical Research Institute, Wirral, Merseyside CH46 1QW (United Kingdom)
We report the formation and structural properties of co-crystals containing gemfibrozil and hydroxy derivatives of t-butylamine H{sub 2}NC(CH{sub 3}){sub 3-} {sub n} (CH{sub 2}OH) {sub n} , with n=0, 1, 2 and 3. In each case, a 1:1 co-crystal is formed, with transfer of a proton from the carboxylic acid group of gemfibrozil to the amino group of the t-butylamine derivative. All of the co-crystal materials prepared are polycrystalline powders, and do not contain single crystals of suitable size and/or quality for single crystal X-ray diffraction studies. Structure determination of these materials has been carried out directly from powder X-ray diffraction data, using the direct-space Genetic Algorithm technique for structure solution followed by Rietveld refinement. The structural chemistry of this series of co-crystal materials reveals well-defined structural trends within the first three members of the family (n=0, 1, 2), but significantly contrasting structural properties for the member with n=3. - Graphical abstract: Structural properties of a family of co-crystals containing gemfibrozil and hydroxy derivatives of t-butylamine are discussed and rationalized.
- OSTI ID:
- 21015748
- Journal Information:
- Journal of Solid State Chemistry, Vol. 180, Issue 3; Other Information: DOI: 10.1016/j.jssc.2006.12.036; PII: S0022-4596(07)00019-9; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0022-4596
- Country of Publication:
- United States
- Language:
- English
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