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Title: Immunologic changes in TNF-alpha, sE-selectin, sP-selectin, sICAM-1, and IL-8 in pediatric patients treated for psoriasis with the Goeckerman regimen

Abstract

Psoriasis is a chronic inflammatory skin disease which is often manifested during childhood. The present study investigated changes in the serum levels of proinflammatory cytokines and soluble forms of adhesion molecules in children with psoriasis. The observed patient group of 26 children was treated with the Goeckerman regimen. This therapy combines dermal application of crude coal tar with ultraviolet radiation. The Psoriasis Area Severity Index decreased significantly after treatment by with the Goeckerman regimen (p < 0.001). Serum levels of the proinflammatory cytokine TNF-alpha and adhesion molecules sICAM-1, sP-selectin and sE-selectin decreased after the Goeckerman regimen. The TNF-alpha and sICAM-1 decreased significantly (p < 0.05). Our findings support the complex role of these immune parameters in the immunopathogenesis of psoriasis in children. The serum level of IL-8 increased after the Goeckerman regimen. This fact indicates that the chemokine pathway of IL-8 activity could be modulated by this treatment, most likely by polycyclic aromatic hydrocarbons.

Authors:
; ; ; ; ; ; ;  [1]
  1. Charles University of Prague, Hradec Kralove (Czech Republic). Faculty of Medicine
Publication Date:
OSTI Identifier:
21004578
Resource Type:
Journal Article
Resource Relation:
Journal Name: Pediatric Dermatology; Journal Volume: 24; Journal Issue: 6
Country of Publication:
United States
Language:
English
Subject:
01 COAL, LIGNITE, AND PEAT; COAL TAR; OINTMENTS; PSORIASIS; CHILDREN; THERAPY; ULTRAVIOLET RADIATION

Citation Formats

Borska, L., Fiala, Z., Krejsek, J., Andrys, C., Vokurkova, D., Hamakova, K., Kremlacek, J., and Ettler, K.. Immunologic changes in TNF-alpha, sE-selectin, sP-selectin, sICAM-1, and IL-8 in pediatric patients treated for psoriasis with the Goeckerman regimen. United States: N. p., 2007. Web. doi:10.1111/j.1525-1470.2007.00548.x.
Borska, L., Fiala, Z., Krejsek, J., Andrys, C., Vokurkova, D., Hamakova, K., Kremlacek, J., & Ettler, K.. Immunologic changes in TNF-alpha, sE-selectin, sP-selectin, sICAM-1, and IL-8 in pediatric patients treated for psoriasis with the Goeckerman regimen. United States. doi:10.1111/j.1525-1470.2007.00548.x.
Borska, L., Fiala, Z., Krejsek, J., Andrys, C., Vokurkova, D., Hamakova, K., Kremlacek, J., and Ettler, K.. Thu . "Immunologic changes in TNF-alpha, sE-selectin, sP-selectin, sICAM-1, and IL-8 in pediatric patients treated for psoriasis with the Goeckerman regimen". United States. doi:10.1111/j.1525-1470.2007.00548.x.
@article{osti_21004578,
title = {Immunologic changes in TNF-alpha, sE-selectin, sP-selectin, sICAM-1, and IL-8 in pediatric patients treated for psoriasis with the Goeckerman regimen},
author = {Borska, L. and Fiala, Z. and Krejsek, J. and Andrys, C. and Vokurkova, D. and Hamakova, K. and Kremlacek, J. and Ettler, K.},
abstractNote = {Psoriasis is a chronic inflammatory skin disease which is often manifested during childhood. The present study investigated changes in the serum levels of proinflammatory cytokines and soluble forms of adhesion molecules in children with psoriasis. The observed patient group of 26 children was treated with the Goeckerman regimen. This therapy combines dermal application of crude coal tar with ultraviolet radiation. The Psoriasis Area Severity Index decreased significantly after treatment by with the Goeckerman regimen (p < 0.001). Serum levels of the proinflammatory cytokine TNF-alpha and adhesion molecules sICAM-1, sP-selectin and sE-selectin decreased after the Goeckerman regimen. The TNF-alpha and sICAM-1 decreased significantly (p < 0.05). Our findings support the complex role of these immune parameters in the immunopathogenesis of psoriasis in children. The serum level of IL-8 increased after the Goeckerman regimen. This fact indicates that the chemokine pathway of IL-8 activity could be modulated by this treatment, most likely by polycyclic aromatic hydrocarbons.},
doi = {10.1111/j.1525-1470.2007.00548.x},
journal = {Pediatric Dermatology},
number = 6,
volume = 24,
place = {United States},
year = {Thu Nov 15 00:00:00 EST 2007},
month = {Thu Nov 15 00:00:00 EST 2007}
}