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Title: Human genetic susceptibility and infection with Leishmania peruviana

Abstract

Racial differences, familial clustering, and murine studies are suggestive of host genetic control of Leishmania infections. Complex segregation analysis has been carried out by use of the programs POINTER and COMDS and data from a total population survey, comprising 636 nuclear families, from an L. perurviana endemic area. The data support genetic components controlling susceptibility to clinical leishmaniasis, influencing severity of disease and resistance to disease among healthy individuals. A multifactorial model is favored over a sporadic model. Two-locus models provided the best fit to the data, the optimal model being a recessive gene (frequency .57) plus a modifier locus. Individuals infected at an early age and with recurrent lesions are genetically more susceptible than those infected with a single episode of disease at a later age. Among people with no lesions, those with a positive skin-test response are genetically less susceptible than those with a negative response. The possibility of the involvement of more than one gene together with environmental effects has implications for the design of future linkage studies. 31 refs., 7 tabs.

Authors:
; ;  [1]
  1. and others
Publication Date:
OSTI Identifier:
209910
Resource Type:
Journal Article
Journal Name:
American Journal of Human Genetics
Additional Journal Information:
Journal Volume: 57; Journal Issue: 5; Other Information: PBD: Nov 1995
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; PATIENTS; INFECTIOUS DISEASES; TUBERCULOSIS; LEPROSY; GENES; DISEASE INCIDENCE; RISK ASSESSMENT; MATHEMATICAL MODELS; PATHOGENS; ENVIRONMENTAL EXPOSURE; RECESSIVE MUTATIONS; STATISTICS; P CODES; C CODES; MACROPHAGES

Citation Formats

Shaw, M.A., Davis, C.R., and Collins, A. Human genetic susceptibility and infection with Leishmania peruviana. United States: N. p., 1995. Web.
Shaw, M.A., Davis, C.R., & Collins, A. Human genetic susceptibility and infection with Leishmania peruviana. United States.
Shaw, M.A., Davis, C.R., and Collins, A. Wed . "Human genetic susceptibility and infection with Leishmania peruviana". United States.
@article{osti_209910,
title = {Human genetic susceptibility and infection with Leishmania peruviana},
author = {Shaw, M.A. and Davis, C.R. and Collins, A.},
abstractNote = {Racial differences, familial clustering, and murine studies are suggestive of host genetic control of Leishmania infections. Complex segregation analysis has been carried out by use of the programs POINTER and COMDS and data from a total population survey, comprising 636 nuclear families, from an L. perurviana endemic area. The data support genetic components controlling susceptibility to clinical leishmaniasis, influencing severity of disease and resistance to disease among healthy individuals. A multifactorial model is favored over a sporadic model. Two-locus models provided the best fit to the data, the optimal model being a recessive gene (frequency .57) plus a modifier locus. Individuals infected at an early age and with recurrent lesions are genetically more susceptible than those infected with a single episode of disease at a later age. Among people with no lesions, those with a positive skin-test response are genetically less susceptible than those with a negative response. The possibility of the involvement of more than one gene together with environmental effects has implications for the design of future linkage studies. 31 refs., 7 tabs.},
doi = {},
journal = {American Journal of Human Genetics},
number = 5,
volume = 57,
place = {United States},
year = {1995},
month = {11}
}