Group 2 coronaviruses prevent immediate early interferon induction by protection of viral RNA from host cell recognition

doi:10.1016/j.virol.2007.01.020

Title: Group 2 coronaviruses prevent immediate early interferon induction by protection of viral RNA from host cell recognition

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Abstract

Many viruses encode antagonists to prevent interferon (IFN) induction. Infection of fibroblasts with the murine hepatitis coronavirus (MHV) and SARS-coronavirus (SARS-CoV) did not result in nuclear translocation of interferon-regulatory factor 3 (IRF3), a key transcription factor involved in IFN induction, and induction of IFN mRNA transcription. Furthermore, MHV and SARS-CoV infection could not prevent IFN induction by poly (I:C) or Sendai virus, suggesting that these CoVs do not inactivate IRF3-mediated transcription regulation, but apparently prevent detection of replicative RNA by cellular sensory molecules. Our data indicate that shielding of viral RNA to host cell sensors might be the main general mechanism for coronaviruses to prevent IFN induction.

Authors:

Versteeg, Gijs A. ^[1]; Bredenbeek, Peter J. ^[1]; Worm, Sjoerd H.E. van den ^[1]; Spaan, Willy J.M. ^[2]

Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, LUMC E4-P, P.O. Box 9600, 2300 RC Leiden (Netherlands)
Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, LUMC E4-P, P.O. Box 9600, 2300 RC Leiden (Netherlands). E-mail: w.j.m.spaan@lumc.nl

Publication Date:: Wed Apr 25 00:00:00 EDT 2007

OSTI Identifier:: 20977015

Resource Type:: Journal Article

Resource Relation:: Journal Name: Virology; Journal Volume: 361; Journal Issue: 1; Other Information: DOI: 10.1016/j.virol.2007.01.020; PII: S0042-6822(07)00044-X; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES; FIBROBLASTS; GENE REGULATION; HEPATITIS; INTERFERON; RNA; SHIELDING; TRANSCRIPTION; TRANSCRIPTION FACTORS; TRANSLOCATION; VIRUSES

Citation Formats


                    Versteeg, Gijs A., Bredenbeek, Peter J., Worm, Sjoerd H.E. van den, and Spaan, Willy J.M. Group 2 coronaviruses prevent immediate early interferon induction by protection of viral RNA from host cell recognition.  United States: N. p., 2007. 
        Web.  doi:10.1016/j.virol.2007.01.020.

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                    Versteeg, Gijs A., Bredenbeek, Peter J., Worm, Sjoerd H.E. van den, & Spaan, Willy J.M. Group 2 coronaviruses prevent immediate early interferon induction by protection of viral RNA from host cell recognition.  United States.  doi:10.1016/j.virol.2007.01.020.

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                    Versteeg, Gijs A., Bredenbeek, Peter J., Worm, Sjoerd H.E. van den, and Spaan, Willy J.M. Wed .  
        "Group 2 coronaviruses prevent immediate early interferon induction by protection of viral RNA from host cell recognition".  United States.  
        doi:10.1016/j.virol.2007.01.020.

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@article{osti_20977015,

  title        = {Group 2 coronaviruses prevent immediate early interferon induction by protection of viral RNA from host cell recognition},

  author       = {Versteeg, Gijs A. and Bredenbeek, Peter J. and Worm, Sjoerd H.E. van den and Spaan, Willy J.M.},

  abstractNote = {Many viruses encode antagonists to prevent interferon (IFN) induction. Infection of fibroblasts with the murine hepatitis coronavirus (MHV) and SARS-coronavirus (SARS-CoV) did not result in nuclear translocation of interferon-regulatory factor 3 (IRF3), a key transcription factor involved in IFN induction, and induction of IFN mRNA transcription. Furthermore, MHV and SARS-CoV infection could not prevent IFN induction by poly (I:C) or Sendai virus, suggesting that these CoVs do not inactivate IRF3-mediated transcription regulation, but apparently prevent detection of replicative RNA by cellular sensory molecules. Our data indicate that shielding of viral RNA to host cell sensors might be the main general mechanism for coronaviruses to prevent IFN induction.},

  doi          = {10.1016/j.virol.2007.01.020},

  journal      = {Virology},

  number       = 1,

  volume       = 361,

  place        = {United States},

  year         = {Wed Apr 25 00:00:00 EDT 2007},

  month        = {Wed Apr 25 00:00:00 EDT 2007}

}

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DOI: 10.1016/j.virol.2007.01.020

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