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Title: The effect of centaurein on interferon-{gamma} expression and Listeria infection in mice

Abstract

We previously found that centaurein enhanced IFN-{gamma} transcription in T cells. Here, we demonstrate that centaurein increased the IFN-{gamma} expression in T and NK cells and the serum IFN-{gamma} level in mice. Centaurein elevated the transcription of T-bet but not GATA-3, which is consistent with its effect on that of IFN-{gamma} but not IL-4. Additionally, centaurein effectively protected mice against Listeria infection. Moreover, centaurein per se or in combination with antibiotics could treat Listeria infection. Our mechanistic studies suggest that centaurein augments IFN-{gamma} expression via a transcriptional up-regulation of T-bet and that centaurein protects against or treats Listeria infection via a modulation of IFN-{gamma} expression.

Authors:
 [1];  [2];  [1];  [2];  [1];  [1];  [3];  [4]
  1. Agricultural Biotechnology Research Center, 128, Sec. 2, Academia Road, Nankang, Taipei 115, Taiwan (China)
  2. (China)
  3. Department of Biological Science and Technology, National Chiao Tung University, 1001, Ta Hsueh Road, Hsinchu 300, Taiwan (China). E-mail: tkwmll@mail.nctu.edu.tw
  4. Agricultural Biotechnology Research Center, 128, Sec. 2, Academia Road, Nankang, Taipei 115, Taiwan (China). E-mail: wcyang@gate.sinica.edu.tw
Publication Date:
OSTI Identifier:
20976869
Resource Type:
Journal Article
Resource Relation:
Journal Name: Toxicology and Applied Pharmacology; Journal Volume: 219; Journal Issue: 1; Other Information: DOI: 10.1016/j.taap.2006.11.026; PII: S0041-008X(06)00455-8; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ACETATES; ANTIBIOTICS; FLUORESCENCE; INTERFERON; LEAD SULFIDES; MICE; MODULATION; NATURAL KILLER CELLS; PHOSPHATES; PHYTOHEMAGGLUTININ; SORTING; TRANSCRIPTION

Citation Formats

Chang, S.-L., Department of Biological Science and Technology, National Chiao Tung University, 1001, Ta Hsueh Road, Hsinchu 300, Taiwan, Yeh, H.-H., Department of Biological Science and Technology, National Chiao Tung University, 1001, Ta Hsueh Road, Hsinchu 300, Taiwan, Lin, Y.-S., Chiang, Y.-M., Wu, T.-K., and Yang, W.-C. The effect of centaurein on interferon-{gamma} expression and Listeria infection in mice. United States: N. p., 2007. Web. doi:10.1016/j.taap.2006.11.026.
Chang, S.-L., Department of Biological Science and Technology, National Chiao Tung University, 1001, Ta Hsueh Road, Hsinchu 300, Taiwan, Yeh, H.-H., Department of Biological Science and Technology, National Chiao Tung University, 1001, Ta Hsueh Road, Hsinchu 300, Taiwan, Lin, Y.-S., Chiang, Y.-M., Wu, T.-K., & Yang, W.-C. The effect of centaurein on interferon-{gamma} expression and Listeria infection in mice. United States. doi:10.1016/j.taap.2006.11.026.
Chang, S.-L., Department of Biological Science and Technology, National Chiao Tung University, 1001, Ta Hsueh Road, Hsinchu 300, Taiwan, Yeh, H.-H., Department of Biological Science and Technology, National Chiao Tung University, 1001, Ta Hsueh Road, Hsinchu 300, Taiwan, Lin, Y.-S., Chiang, Y.-M., Wu, T.-K., and Yang, W.-C. Thu . "The effect of centaurein on interferon-{gamma} expression and Listeria infection in mice". United States. doi:10.1016/j.taap.2006.11.026.
@article{osti_20976869,
title = {The effect of centaurein on interferon-{gamma} expression and Listeria infection in mice},
author = {Chang, S.-L. and Department of Biological Science and Technology, National Chiao Tung University, 1001, Ta Hsueh Road, Hsinchu 300, Taiwan and Yeh, H.-H. and Department of Biological Science and Technology, National Chiao Tung University, 1001, Ta Hsueh Road, Hsinchu 300, Taiwan and Lin, Y.-S. and Chiang, Y.-M. and Wu, T.-K. and Yang, W.-C.},
abstractNote = {We previously found that centaurein enhanced IFN-{gamma} transcription in T cells. Here, we demonstrate that centaurein increased the IFN-{gamma} expression in T and NK cells and the serum IFN-{gamma} level in mice. Centaurein elevated the transcription of T-bet but not GATA-3, which is consistent with its effect on that of IFN-{gamma} but not IL-4. Additionally, centaurein effectively protected mice against Listeria infection. Moreover, centaurein per se or in combination with antibiotics could treat Listeria infection. Our mechanistic studies suggest that centaurein augments IFN-{gamma} expression via a transcriptional up-regulation of T-bet and that centaurein protects against or treats Listeria infection via a modulation of IFN-{gamma} expression.},
doi = {10.1016/j.taap.2006.11.026},
journal = {Toxicology and Applied Pharmacology},
number = 1,
volume = 219,
place = {United States},
year = {Thu Feb 15 00:00:00 EST 2007},
month = {Thu Feb 15 00:00:00 EST 2007}
}